Results 61 to 70 of about 317,930 (233)
Upper and lower solution method for boundary value problems at resonance
Electronic Journal of Qualitative Theory of Differential Equations, 2016 We consider two simple boundary value problems at resonance for an ordinary differential equation. Employing a shift argument, a regular fixed point operator is constructed. We employ the monotone method coupled with a method of upper and lower solutions
Samerah Al Mosa, Paul Eloe
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
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Existence of solutions for Kirchhoff-type problems via the method of lower and upper solutions
Electronic Journal of Differential Equations, 2019 This article considers elliptic problems of Kirchhoff-type. We give some new definitions of lower and upper solutions for the problem and establish the method of lower and upper solutions when the upper and lower solutions are well ordered, i.e., the ...
Baoqiang Yan +2 more
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International Journal of Differential Equations, 2011 We consider a kind of Sturm-Liouville boundary value problems. Using variational techniques combined with the methods of upper-lower solutions, the existence of at least one positive solution is established.
Li Zhang, Xiankai Huang, Weigao Ge
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
On lower and upper solutions without ordering on time scales
Advances in Difference Equations, 2006 In order to enlarge the set of boundary value problems on time scales, for which we can use the lower and upper solutions technique to get existence of solutions, we extend this method to the case when the pair lacks ordering.
Stehlík Petr
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
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