Results 61 to 70 of about 8,669,989 (253)
A direct method for the evaluation of lower and upper bound ratchet limits [PDF]
, 2011 The calculation of the ratchet limit is often vital for the assessment of the design and integrity of components which are subject to cyclic loading. This work describes the addition of a lower bound calculation to the existing Linear Matching Method ...
Ure, James Michael +5 more
core +3 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Upper and lower bound solutions for lateral-torsional buckling of doubly symmetric members
, 2016 A family of three finite elements is developed for the lateral-torsional buckling analysis of thin-walled members with doubly symmetric cross-sections.
Sahraei, Arash, Mohareb, Magdi
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
International Journal of Differential Equations, 2011 We consider a kind of Sturm-Liouville boundary value problems. Using variational techniques combined with the methods of upper-lower solutions, the existence of at least one positive solution is established.
Li Zhang, Xiankai Huang, Weigao Ge
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Positive solutions of nonlinear fourth-order boundary-value problems with local and non-local boundary conditions [PDF]
, 2008 We establish new existence results for multiple positive solutions of fourth-order nonlinear equations which model deflections of an elastic beam. We consider the widely studied boundary conditions corresponding to clamped and hinged ends and many non ...
J. R. L. Webb +5 more
core +1 more source
On lower and upper solutions without ordering on time scales
Advances in Difference Equations, 2006 In order to enlarge the set of boundary value problems on time scales, for which we can use the lower and upper solutions technique to get existence of solutions, we extend this method to the case when the pair lacks ordering.
Stehlík Petr
doaj
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source