Results 31 to 40 of about 1,789,428 (238)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Three nontrivial solutions for the p-Laplacian Neumann problems with a concave nonlinearity near the origin [PDF]

, 2010
We consider a nonlinear Neumann problem driven by the p- Laplacian, with a right-hand side nonlinearity which is concave near the origin. Using variational techniques, combined with the method of upper-lower solutions and with Morse theory, we show ...
Aizicovici, Sergiu, Papageorgiou, Nikolaos, Staicu, Vasile   +2 more
core   +1 more source

Lower and Upper Solutions for Singular Derivative Dependent Dirichlet Problem [PDF]

Mathematical Inequalities & Applications, 2001
The author develops the lower and upper solution method to work out the Dirichlet problem \[ u''+f(t,u,u')=0,\quad u(a)=0,\;u(b)=0, \] where \(f\) can be singular for \(t=a\), \(t=b\) and \(u=0\). Solutions are supposed to be in \(W^{1,1}(a,b)\cap W^{2,1}_{loc}(a,b)\).
openaire   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A method of upper and lower solutions for functional differential inclusions [PDF]

International Journal of Stochastic Analysis, 2002
In this paper, a fixed point theorem for condensing maps combined with upper and lower solutions are used to investigate the existence of solutions for first order functional differential inclusions.
Benchohra, Mouffak, Ntouyas, Sotiris K.
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Exact solution for a fermion in the background of a scalar inversely linear potential

, 2004
The problem of a fermion subject to a general scalar potential in a two-dimensional world is mapped into a Sturm-Liouville problem for nonzero eigenenergies. The searching for possible bounded solutions is done in the circumstance of power-law potentials.
't Hooft, Abramowitz, Antonio S. de Castro, Bagrov, Bhalerao, Capri, Cavalcanti, Coleman, Coleman, Cooper, Coutinho, Coutinho, de Castro, de Castro, Flügge, Fröhlich, Galić, Hiller, Ho, Kogut, Kratzer, Landau, Moss, Nogami, Nogami, Spector, Strange, Thaller   +27 more
core   +1 more source

Upper–lower solutions for nonlinear parabolic systems and their applications

Journal of Mathematical Analysis and Applications, 2011
A method of upper and lower-solutions for nonlinear time-dependent reaction-diffusion systems of the type \[ \begin{cases} {\partial \over {\partial t}} u_i(x,t) - d_i \Delta u_i(x,t)= f_i(u_1,\dots,u_m, x) \quad \text{ for } x\in \Omega \subset \mathbb R^m \\ \alpha_i u_i(x,t) + \beta_i {\partial \over \partial n} u_i(x,t) = \psi_i(u_1,\dots,u_{i-1 ...
Abudiab, Mufid, Ahn, Inkyung, Li, Lige
openaire   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source