Results 71 to 80 of about 4,152,384 (323)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Linear programming bounds for doubly-even self-dual codes [PDF]

, 1997
Using a variant of linear programming method we derive a new upper bound on the minimum distance d of doubly-even self-dual codes of length n. Asymptotically, for n growing, it gives d/n
Krasikov, I, Simon Litsyn, Ilia Krasikov, I. Krasikov, S. Litsyn   +4 more
core   +2 more sources

Null injectivity estimate under an upper curvature bound [PDF]

, 2014
We establish a uniform estimate for the injectivity radius of the past null cone of a point in a general Lorentzian manifold foliated by space-like hypersurfaces and satisfying an upper curvature bound.
LeFloch, PG, Grant, JDE
core   +2 more sources

Upper bound analysis for bearing capacity of nonhomogeneous and anisotropic clay foundation

, 2016
The bearing capacity calculations for nonhomogeneous and anisotropic clay foundation are often employed the methods of limit equilibrium, limit analysis and characteristic. In this paper, an approach of upper bound theorem in conjunction with new failure
Xiao-Li Yang, Dian-Chun Du
semanticscholar   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

An Upper Confidence Bound Approach to Estimating the Maximum Mean

CoRR
Estimating the maximum mean finds a variety of applications in practice. In this paper, we study estimation of the maximum mean using an upper confidence bound (UCB) approach where the sampling budget is adaptively allocated to one of the systems. We study in depth the existing grand average (GA) estimator, and propose a new largest-size average (LSA ...
Zhang Kun, Guangwu Liu, Shi Wen
openaire   +3 more sources

Nash Estimates and Upper Bounds for Non-homogeneous Kolmogorov Equations [PDF]

Potential Analysis, 2017
We prove a Gaussian upper bound for the fundamental solutions of a class of ultra-parabolic equations in divergence form. The bound is independent on the smoothness of the coefficients and generalizes some classical results by Nash, Aronson and Davies. The class considered has relevant applications in the theory of stochastic processes, in physics and ...
LANCONELLI, ALBERTO, PASCUCCI, ANDREA
openaire   +4 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source