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Centralisation of Upper Gastrointestinal Cancer Surgery [PDF]

The Annals of The Royal College of Surgeons of England, 2007
Upper gastrointestinal surgery comprised of the separate disciplines of oesophagogastric (OG) and hepato-pancreato-biliary (HPB) surgery includes the operative care of the most complex cancers in alimentary surgery. Historically, any given general surgeon would see relatively few cases each year, resect even fewer and outcomes were notoriously poor.1,2
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Prevalence of elevated Anti-p53 in Chinese patients with upper gastrointestinal or colorectal cancer

The International Journal of Biological Markers, 2022
Background The monitoring of anti-p53 auto-antibodies in the peripheral blood has been used in cancer management; however, their clinical significance alone is limited.
Min Wang, Suhong Xie, Xiang Gao, Jingjing Feng, Minjie Deng, Jiajun Sun, Ying He, Horst Donner, Renqun Lu, Lin Guo   +9 more
doaj   +1 more source

A Radiomics Nomogram Integrated With Clinic-Radiological Features for Preoperative Prediction of DNA Mismatch Repair Deficiency in Gastric Adenocarcinoma

Frontiers in Oncology, 2022
PurposeTo develop and validate a radiomics nomogram integrated with clinic-radiological features for preoperative prediction of DNA mismatch repair deficiency (dMMR) in gastric adenocarcinoma.Materials and MethodsFrom March 2014 to August 2020, 161 ...
Yahan Tong, Yahan Tong, Yahan Tong, Jiaying Li, Jiaying Li, Jieyu Chen, Jieyu Chen, Can Hu, Can Hu, Can Hu, Zhiyuan Xu, Zhiyuan Xu, Zhiyuan Xu, Shaofeng Duan, Xiaojie Wang, Risheng Yu, Xiangdong Cheng, Xiangdong Cheng, Xiangdong Cheng   +18 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

PMMA nanoplastics induce gastric epithelial cellular senescence and cGAS-STING-mediated inflammation via ROS overproduction and NHEJ suppression

Ecotoxicology and Environmental Safety
The increasing environmental presence of nanoplastics (NPs) has raised concerns about their potential impact on biological systems. We investigated the repercussions of polymethyl methacrylate (PMMA) NPs exposure on normal gastric epithelial cells and ...
Xiao Li, Yixing Huang, Dan Zu, Haidong Liu, Hanyi He, Qimei Bao, Yanhua He, Chen Liang, Guoyan Luo, Yaoshu Teng, Yin Shi, Zu Ye, Xiangdong Cheng   +12 more
doaj   +1 more source

Colorectal endoscopic submucosal dissection can be efficiently performed by a trainee with use of a simple traction device and expert supervision

Endoscopy International Open, 2019
Background and study aims Colorectal endoscopic submucosal dissection (ESD) is technically challenging owing to submucosal fibrosis and difficult endoscope manipulation. Therefore, various traction methods have been reported. We often use a simple looped
Daisuke Ide, Shoichi Saito, Tomohiko Richard Ohya, Yuske Nishikawa, Yoshimasa Horie, Chihiro Yasue, Akiko Chino, Masahiro Igarashi, Masayuki Saruta, Junko Fujisaki   +9 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source