Results 181 to 190 of about 83,604 (268)

Oncological Genetic Counseling in Hereditary Breast and Ovarian Cancers and Lynch Syndrome High-Risk Subjects: Evaluation of Efficacy and Outcomes Using the Genomics Outcome Scale. [PDF]

Hum Mutat
Maccaroni E, Chiariotti R, Giampieri R, Bianchi F, Brugiati C, Belvederesi L, Ambrosini E, Chiodi N, Serritelli EN, Morgese F, Agostinelli V, Mentrasti G, Copparoni C, Magnarini A, De Filippis C, Burattini E, Bracci R, Chiari R, Del Prete M, Bisonni R, Faloppi L, Battelli N, Silva RR, Berardi R.   +23 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Bioinformatic analysis of metastasis-associated metabolic landscape reveals an oncogenic role for the transsulfuration pathway. [PDF]

Bioinform Adv
Yan JK, Yang Y, Wang W.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A network analysis of ICD-11 complex posttraumatic stress disorder symptoms in Danish treatment-seeking military veterans. [PDF]

BMC Psychiatry
Lund C, Karstoft KI, Nielsen ABS, Folke S.   +3 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Hereditary kidney tumor syndromes: structured evaluation of a questionnaire-based approach. [PDF]

Clin Kidney J
Degenhardt J, von Zehmen T, Beck B, Erger F, Heidenreich A, Müller RU, Paffenholz P.   +6 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Health-related quality of life (HRQoL) of women with breast cancer undergoing treatment in a tertiary care centre in India. [PDF]

J Patient Rep Outcomes
Patra A, Nag S, Kulkarni SS, DeSouza R, Pant HB, Agiwal V, Nirupama AY, Murthy GVS.   +7 more
europepmc   +1 more source