Results 191 to 200 of about 83,604 (268)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

MiR-21-5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression. [PDF]

Compr Physiol
Krause BJ, Calle X, Kumar RV, Niu Y, Ramirez-Herrera O, Gonzalez D, Bernal B, Ford SG, Crew RC, Cochrane ALK, Arenas GA, Di Genova A, Giussani DA.   +12 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Temporal variation in markers of immune signaling and wound repair in primary human airway epithelial cells following acute versus repeated woodsmoke condensate exposure. [PDF]

Toxicol Sci
Hickman E, Chou CK, Seifert C, Chappel J, Kim YH, Corteselli E, Rager JE.   +6 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Dynamic development of muscle during embryogenesis in Arbor Acres broilers and TaoYuan chickens revealed by RNA sequencing. [PDF]

BMC Genomics
Zhao D, Shi Y, Ouyang Q, Zhang H, Guo Y, Song Z, He X.   +6 more
europepmc   +1 more source

Self-reported experiences of interpersonal racial discrimination and maternal and neonatal health: a systematic review and meta-analysis. [PDF]

Front Reprod Health
Adesunkanmi M, Zhou SJA, Al-Shamali HF, Amjad S, Pitt TM, Salami O, Serrano-Lomelin J, Ospina MB.   +7 more
europepmc   +1 more source

Modeling injury severity among motor vehicle occupants using a safe system-aligned, population-based framework: evidence from Ohio crash data (2017-2023). [PDF]

Inj Epidemiol
Harden AL, Cole ME, Bautsch B, Shoots-Reinhard B, Kinn C, Cardoni L, Thompson J, Bolte JH.   +7 more
europepmc   +1 more source

Development and preliminary psychometric evaluation of the symptoms of autistic depression-parent scale. [PDF]

Front Pediatr
Derby B, Wilson L, Kelley E.
europepmc   +1 more source

Introducing gold-standard essential gene datasets for Pseudomonas aeruginosa to enhance Tn-Seq analyses. [PDF]

PLoS Comput Biol
Van Maele C, Caboche S, Nicolau-Guillaumet N, Muggeo A, Guillard T.   +4 more
europepmc   +1 more source