Results 221 to 230 of about 86,414 (313)

Tautomerism‐Governed Two‐Proton‐Coupled Electron Transfer in the Oxidation of a Molnupiravir by Electrogenerated Superoxide Radical Anion in N,N‐Dimethylformamide

open access: yesChemistrySelect, Volume 11, Issue 21, 4 June 2026.
Tautomerization‐assisted oxidation of molnupiravir by superoxide (O2•−) in aprotic DMF. The thermodynamically favored oxime tautomer of the N4‐hydroxycytosine moiety forms a prereactive complex (PRC) with O2•− through hydrogen‐bonding interactions.
Tatsushi Nakayama, Kaisei Hara
wiley   +1 more source

Advances in cholesterol and lipoproteins detection for healthcare: A review

open access: yesVIEW, Volume 7, Issue 3, June 2026.
Cholesterol is one of the main biomarkers related to the development of cardiovascular diseases. Its detection still relies on traditional methods of analysis, such as gas and liquid chromatographies. Detection of free cholesterol in saliva with redox or enzymatic sensors or detection of lipoproteins in blood with aptamer sensors are currently the most
Jacopo Giaretta   +7 more
wiley   +1 more source

Nuclear Magnetic Resonance–Based Urinary Metabolic Profiling for Assessing Heat Stress–Related Incident Kidney Injury in Health‐Care Workers

open access: yesGeoHealth, Volume 10, Issue 6, June 2026.
Abstract During the COVID‐19 pandemic, heat stress (HS) was a serious occupational risk for health‐care workers (HCWs) wearing personal protective equipment, which limits heat dissipation and increases the risk of kidney injury. In this exploratory study, we assessed HS‐related changes in the urinary metabolites of 38 HCWs working at mobile COVID‐19 ...
Cheng‐Yu Ting   +9 more
wiley   +1 more source

Urate‐Related Genetic Risk Modulates the Anti‐Aging Effects of Exogenous Nucleotides: Multi‐Omics Evidence From Older Adults

open access: yesAging Cell, Volume 25, Issue 6, June 2026.
In the TALENTs trial, 19‐week exogenous nucleotide supplementation produced UA‐PRS‐dependent anti‐aging responses: reduced DNA methylation age in High‐PRS individuals and preserved telomere length with improved immune–inflammatory profiles in Low‐PRS individuals, supporting precision nutrition for healthy aging.
Ruisheng Fu   +6 more
wiley   +1 more source

Effects of thymidylate synthase inhibitors differ in genomic uracilation and mutagenic potential. [PDF]

open access: yesLife Sci Alliance
Holub E   +7 more
europepmc   +1 more source

A SMUG1 Inhibitor Modulates the Excision of Pyrimidine DNA Damage. [PDF]

open access: yesACS Med Chem Lett
Thacker PS   +8 more
europepmc   +1 more source

Genome‐wide and gene‐specific DNA methylation across developmental stages in Pogonomyrmex californicus: A socially polymorphic ant

open access: yesInsect Molecular Biology, Volume 35, Issue 3, Page 232-245, June 2026.
Comparison between developmental stages (larvae, pupae, worker) in Pogonomyrmex californicus revealed significant stage‐specific differences in Gene Body Methylated frequencies. Methylation sites were highly correlated between WGBS and ONT in P. californicus Genome‐wide methylation was low (~3%) and highly clustered within gene bodies (GBM), especially
Tania Chavarria‐Pizarro   +4 more
wiley   +1 more source

Association of DPYD rs4294451, plasma uracil concentration, and sex with 5-fluorouracil exposure in patients with gastrointestinal cancer. [PDF]

open access: yesCancer Chemother Pharmacol
Brooks GA   +12 more
europepmc   +1 more source

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