Results 191 to 200 of about 480,464 (254)

Halofuginone is a Molecular Glue Degrader of Integrin β4

open access: yesAdvanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong   +8 more
wiley   +1 more source

Disulfide‐Bridged Ru Complex–Mediated Photo‐Disulfidptosis for Colorectal Cancer Therapy

open access: yesAdvanced Science, EarlyView.
In this work, a binuclear ruthenium complex, RuSSRu was developed for efficient colorectal cancer (CRC) treatment. The synergistic interaction between disulfidptosis and lysosomal damage‐induced apoptosis induced by RuSSRu amplified tumor cell death. This innovative approach offers a potent therapeutic strategy for CRC.
Simeng He   +8 more
wiley   +1 more source

Nitrogen Source-Carbohydrate Synchronization in Ruminant Nutrition: A Systematic Review. [PDF]

open access: yesAnimals (Basel)
Bezerra LR   +9 more
europepmc   +1 more source

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