Results 121 to 130 of about 3,294,575 (284)

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Psychosocial issues that influence Urea Cycle Disorder families' decision to participeate [i.e. participate] in research

, 2007
This is a cross-sectional mixed study on families with a member with a Urea Cycle Disorder, an inborn error of metabolism. UCDs are genetic disorders that are caused by an alteration of a specific chemical reaction in metabolism, causing the impairment ...
Ateerat, Alisara
core  

Biochemical markers and neuropsychological functioning in distal urea cycle disorders

, 2018
Urea cycle disorders often present as devastating metabolic conditions, resulting in high mortality and significant neuropsychological damage, despite treatment.
Cederbaum, Stephen, Robert McCarter, Waisbren, Susan E; https://orcid.org/, Amy Holbert, Susan E. Waisbren, Peter Burgard, Stephen Cederbaum, McCarter, Robert, null null, Holbert, Amy, David Cuthbertson, Burgard, Peter, Cuthbertson, David   +12 more
core   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Urea cycle.

, 2016
In the urea cycle the “toxin” ammonium (NH4+) is converted to non-toxic urea by five consecutive enzymatic reactions in the liver. In hepatocytes, the rate-limiting, ATP-dependent enzyme carbamoyl phosphate synthetase 1 (CPS1), which is allosterically ...
Matthias Gautschi (2608306), Tamar Stricker (2608312), Adrian Keogh (174242), Johannes Häberle (719209), Renata C. Gallagher (2608315), Alexander Laemmle (174189), Jean-Marc Nuoffer (334268), Matthias R. Baumgartner (2608309)   +7 more
core   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Rasio Urea-Metanol Dalam Proses Metanolisis Urea Secara Visual

, 2010
Telah dilakukan perbaikan rasio urea-metanol sebagai reaktan dalam pembuatan dimetil karbonat (DMC). Dimetil Karbonat adalah bahan dasar dalam pembuatan toluen diisosianat yang merupakan hardener Propelan Roket LAPAN RPS 420.
Luthfia Hajar Abdillah
core  

Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

Advanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang   +9 more
wiley   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Nickelferrite on Pnictogen Functionalized Carbon Nanohorns. Bifunctional ORR and OER Catalysts in Rechargeable Zinc‐Air Batteries

Advanced Science, EarlyView.
A systematic study on the performance of N,P‐doped NiFe2O4@CNH bi‐functional hybrid electrocatalysts for rechargeable zinc‐air batteries is presented. The importance of P, N‐doping and the intimate tethering of nickel‐ferrite nanocubes on the carbon nano‐horn (CNH) surface which are well dispersed on the surface of N,P doped CNHs.
Sudheer Kumar Yadav, Vanessa Trouillet, Jonas Lins, Torsten Gutmann, Jörg J. Schneider   +4 more
wiley   +1 more source