Results 1 to 10 of about 12,857 (206)

Guidelines for acute management of hyperammonemia in the Middle East region [PDF]

Therapeutics and Clinical Risk Management, 2016
Majid Alfadhel,1,2 Fuad Al Mutairi,1,2 Nawal Makhseed,3 Fatma Al Jasmi,4 Khalid Al-Thihli,5 Emtithal Al-Jishi,6 Moeenaldeen AlSayed,7 Zuhair N Al-Hassnan,7,8 Fathiya Al-Murshedi,5 Johannes Häberle,9 Tawfeg Ben-Omran10 Middle East Hyperammonemia and
Alfadhel M, Al Mutairi F, Makhseed N, Al Jasmi F, Al-Thihli K, Al-Jishi E, AlSayed M, Al-Hassnan ZN, Al-Murshedi F, Häberle J, Ben-Omran T   +10 more
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New developments in the treatment of hyperammonemia: emerging use of carglumic acid [PDF]

International Journal of General Medicine, 2011
Marta Daniotti1, Giancarlo la Marca2, Patrizio Fiorini1, Luca Filippi11Neonatal Intensive Care Unit, Department of Perinatal Medicine, “A. Meyer” University Children’s Hospital, Florence, Italy; 2Mass Spectrometry, Clinical ...
Marta Daniotti, Giancarlo la Marca, Patrizio Fiorini, et al   +3 more
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Idiopathic hyperammonemia after chemotherapy with vinorelbine, topotecan, and cisplatin in a patient with acute lymphocytic leukemia

Hematology/Oncology and Stem Cell Therapy, 2010
Idiopathic hyperammonemia (IHA) had been reported in some patients with hematological malignancy after receiving intensive chemotherapy, following bone marrow transplantation, or after using 5-fluorouuracil for some solid tumors.
Yu-Hsien Chen, Tzeon-Jye Chiou, Yen-Ning Hsu, Chun-Yu Liu   +3 more
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Clinical and biochemical factors associated with hyperammonemia in inpatients with mental disorders treated with valproic acid: a cross-sectional analysis

Therapeutic Advances in Psychopharmacology
Background: Valproic acid (VPA)-induced hyperammonemia is a common condition whose clinical presentations can range from asymptomatic cases to severe hyperammonemic encephalopathy. This can happen at any stage of treatment and is difficult to predict, as
Ilaria Riboldi, Daniele Cavaleri, Marco Morreale, Cristina Crocamo, Francesco Bartoli, Giuseppe Carrà   +5 more
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The role of MAPK/mTOR pathway in regulating ULK1 mediated autophagy in hyperammonemia induced liver injury

Scientific Reports
Hyperammonemia is frequently encountered in cirrhosis; nevertheless, its direct hepatotoxic effects remain poorly characterized. In this study, we aimed to delineate the hepatotoxic effects of chronic hyperammonemia and and explore the related mechanisms
Binlin Da, Lei Guo, Liming Li, Feng Zhu, Juanjuan Zhang, Zhiming Wang, Feilong Guo   +6 more
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Chronic hyperammonemia alters motor and neurochemical responses to activation of group i metabotropic glutamate receptors in the nucleus accumbens in rats in vivo

Neurobiology of Disease, 2003
Hyperammonemia leads to altered cerebral function and neurological alterations in patients with hepatic encephalopathy. We studied the effects of hyperammonemia in rats on the modulation by group I metabotropic glutamate receptors (mGluR) of motor and ...
Juan-José Canales, Amina Elayadi, Mohammed Errami, Marta Llansola, Omar Cauli, Vicente Felipo   +5 more
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Hyperammonemia impairs long-term potentiation in hippocampus by altering the modulation of cGMP-degrading phosphodiesterase by protein kinase G

Neurobiology of Disease, 2004
Hyperammonemia impairs long-term potentiation (LTP) in hippocampus, by an unknown mechanism. LTP in hippocampal slices requires activation of the soluble guanylate cyclase (sGC)-protein kinase G (PKG)-cGMP-degrading phosphodiesterase pathway.
Pilar Monfort, Marı́a-Dolores Muñoz, Vicente Felipo   +2 more
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Sarcopenia modelling by portal vein ligation inducing hyperammonemia in rats.

PLoS ONE
Sarcopenia is a progressive muscle wasting condition often associated with hyperammonemia. However, no approved animal models of sarcopenia with hyperammonemia were reported.
Maria Nadinskaia, Kseniya Gulyaeva, Aleksandr Sukhinin, Alla Sedova, Polina Boykova, Ilya Izmailov, Ksenia Pokidova, Egor Kuzmin, Artem Venediktov, Igor Meglinski, Gennadii Piavchenko   +10 more
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Fatal hyperammonemia caused by Mycoplasma hominis infection: A rare case report

International Journal of Infectious Diseases
Hyperammonemia, a clinical condition characterized by elevated serum ammonia levels, often leads to altered consciousness and can have severe neurological consequences. It predominantly affects patients with hyperammonemic encephalopathy (HE), urea cycle
Yushi Fan, Lanxin Cao, Tiancha Huang, Chengyang Chen, Hui Shan, Linlin Du, Wei Cui, Gensheng Zhang   +7 more
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Hyperammonemia heightens anesthetic sensitivity in male rats with acute hepatic encephalopathy via affecting brain areas represented by the cerebellum

BMC Anesthesiology
Background Precise anesthesia is essential to ensure perioperative safety in patients with hepatic encephalopathy (HE) due to severe liver injuries. Hyperammonemia has been implicated as a possible trigger for HE.
Sa Wang, Xin-Xin Zhao, Dan Tang, Shi-An Li, Tian-Qi Li, Bing-Xue Peng, Yi-Hao Wang, Sai-Hong Xu, Po Gao, Xue Xue, Ying-Fu Jiao, Yan Zhou, Wei-Feng Yu   +12 more
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