Results 21 to 30 of about 9,393 (183)
Internal Medicine, 2023 A 91-year-old woman was brought to our hospital with altered consciousness. Blood tests showed an increased ammonia level of 468 μg/dL and a normal liver function. Chest computed tomography showed massive right pleural effusion with loculation. We immediately performed chest drainage using two drainage tubes. The pleural effusate pH was 8.5.
Wada, Hiroshi +2 more
openaire +2 more sources
Longitudinal Changes in Glutamine and Ammonia in Relation to Hyperammonemic Crisis in Urea Cycle Disorders. [PDF]
JIMD RepABSTRACT Hyperammonemic crisis (HAC) remains a major risk factor for urea cycle disorders (UCD), and practical outpatient predictors are limited. We tested whether short‐term changes in plasma glutamine (ΔGln) and ammonia (ΔNH3) predict HAC and whether effects differ by onset type. In a retrospective cohort (2014–2024) of 18 patients with UCD (neonatal‐
Yasuda Y +4 more
europepmc +2 more sources
O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis
Nature Communications, 2022 Hyperammonemia occurs in liver diseases affecting ureagenesis, and is life-threatening. Here, the authors show that liver UDP-GlcNAc is increased during hyperammonemia, leading to O-GlcNAcylation of the rate-limiting ureagenesis enzyme CPS1, that ...
Leandro R. Soria +21 more
doaj +1 more source
A Newborn with Hypothermia and Hyperammonemia [PDF]
Clinical Chemistry, 2018 A full-term small gestational age female infant was transferred to the NICU for hypothermia and seizure-like activity. In the first 10 h of life, the infant had difficulty feeding and developed mild hypothermia, which resolved after placing her on a radiant warmer.
Khanh Quynh N, Nguyen +2 more
openaire +2 more sources
Hyperammonemia presenting as opsoclonus–myoclonus–ataxia–tremor syndrome: A case report
Annals of Movement Disorders, 2022 Opsoclonus myoclonus syndrome (OMS) is a rare autoimmune condition occurring due to Purkinje cell degeneration due to remote aetiology. Most often it occurs as a paraneoplastic syndrome.
Sandhya Manorenj, Govind Verma
doaj +1 more source
Hyperammonemia in patients on Valproic Acid therapy in a tertiary care hospital of Karachi
Khyber Medical University Journal, 2023 OBJECTIVE: to assess the incidence of hyperammonemia in patients receiving valproic acid (VPA) therapy. METHODS: This cross-sectional study was conducted at the Department of Neurology, Ziauddin Medical University and Hospital, Karachi, for six months ...
Iqra Ali +2 more
doaj +1 more source
Hyperammonemia and proteostasis in cirrhosis [PDF]
Current Opinion in Clinical Nutrition & Metabolic Care, 2018 Skeletal muscle loss or sarcopenia is a frequent complication of cirrhosis that adversely affects clinical outcomes. As skeletal muscle is the largest store of proteins in the body, proteostasis or protein homeostasis is required for maintenance of muscle mass. This review will focus on disordered skeletal muscle proteostasis in liver disease.Increased
Srinivasan, Dasarathy, Maria, Hatzoglou
openaire +2 more sources
Different types of hyperammonemia in clinical practice
Медицинский совет, 2018 Hyperammonemia is a metabolic disorder, which is caused as a result of high levels of ammonia present in the blood. Hyperammonemia is related to severe liver diseases, primarily to cirrhosis in 90% of cases.
E. Yu. Plotnikova, A. S. Sukhikh
doaj +1 more source
Asthenia and fatigue in hyperammonemia: etiopathogenesis and methods of correction
Медицинский совет, 2022 Asthenia and fatigue are the most common syndromes in patients with liver disease, which significantly affects their quality of life. The prevalence of fatigue in chronic liver diseases is from 50% to 85%.
E. Yu. Plotnikova +2 more
doaj +1 more source
Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase. [PDF]
PLoS ONE, 2018 Hyperammonemia is the common biochemical hallmark of urea cycle disorders, activating neurotoxic pathways. If untreated, affected individuals have a high risk of irreversible brain damage and mortality.
Matthias Zielonka +5 more
doaj +1 more source