A Newborn with Hypothermia and Hyperammonemia [PDF]
A full-term small gestational age female infant was transferred to the NICU for hypothermia and seizure-like activity. In the first 10 h of life, the infant had difficulty feeding and developed mild hypothermia, which resolved after placing her on a radiant warmer.
Khanh Quynh N, Nguyen +2 more
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Hyperammonemia in patients on Valproic Acid therapy in a tertiary care hospital of Karachi
OBJECTIVE: to assess the incidence of hyperammonemia in patients receiving valproic acid (VPA) therapy. METHODS: This cross-sectional study was conducted at the Department of Neurology, Ziauddin Medical University and Hospital, Karachi, for six months ...
Iqra Ali +2 more
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Hyperammonemia and proteostasis in cirrhosis [PDF]
Skeletal muscle loss or sarcopenia is a frequent complication of cirrhosis that adversely affects clinical outcomes. As skeletal muscle is the largest store of proteins in the body, proteostasis or protein homeostasis is required for maintenance of muscle mass. This review will focus on disordered skeletal muscle proteostasis in liver disease.Increased
Srinivasan, Dasarathy, Maria, Hatzoglou
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Different types of hyperammonemia in clinical practice
Hyperammonemia is a metabolic disorder, which is caused as a result of high levels of ammonia present in the blood. Hyperammonemia is related to severe liver diseases, primarily to cirrhosis in 90% of cases.
E. Yu. Plotnikova, A. S. Sukhikh
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Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase. [PDF]
Hyperammonemia is the common biochemical hallmark of urea cycle disorders, activating neurotoxic pathways. If untreated, affected individuals have a high risk of irreversible brain damage and mortality.
Matthias Zielonka +5 more
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Asthenia and fatigue in hyperammonemia: etiopathogenesis and methods of correction
Asthenia and fatigue are the most common syndromes in patients with liver disease, which significantly affects their quality of life. The prevalence of fatigue in chronic liver diseases is from 50% to 85%.
E. Yu. Plotnikova +2 more
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A zebrafish model of hyperammonemia [PDF]
Hyperammonemia is the principal consequence of urea cycle defects and liver failure, and the exposure of the brain to elevated ammonia concentrations leads to a wide range of neuro-cognitive deficits, intellectual disabilities, coma and death. Current treatments focus almost exclusively on either reducing ammonia levels through the activation of ...
B. Feldman, M. Tuchman, L. Caldovic
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Valproic acid induced hyperammonemic encephalopathy: A case report (Turkish) [PDF]
Valproic acid (VPA) is commonly used drug to treat variety of anticonvulsant and mood stabilizer in psychiatric and neurologic cases. It is thought to be a safe drug with a large therapeutic aspect..Uncommonly, hyperammonemia can be progressed by the
Ferda Apa +2 more
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A Case of Hyperammonemia Associated with High Dihydropyrimidine Dehydrogenase Activity
Over the past decades, 5-Fluorouracil (5-FU) has been widely used to treat several types of carcinoma, including esophageal squamous cell carcinoma. In addition to its common side effects, including diarrhea, mucositis, neutropenia, and anemia, 5-FU ...
Keiki Nagaharu +8 more
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Host and fungal factors both contribute to cryptococcosis-associated hyperammonemia (cryptammonia)
Cryptococcus neoformans and Cryptococcus gattii are both known urease producers and have the potential to cause hyperammonemia. We hypothesized that the risk of hyperammonemia is increased by renal failure, burden of cryptococcal infection, and fungal ...
Rosanna P. Baker +6 more
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