Hypoaminoacidemia and Pyroglutamic Aciduria: Potential Biomarkers in Malnutrition‐Related Hyperammonemia [PDF]
JIMD ReportsHyperammonemia is a medical emergency, and the cause must be identified quickly in order to treat appropriately. Malnutrition is a known risk factor for hyperammonemia; however, there are limited reliable lab indicators used to identify malnutrition ...
M. M. Crenshaw +12 more
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Hyperammonemia in patients receiving valproic acid in the hospital setting: A retrospective review [PDF]
Mental Health Clinician, 2021 Introduction: Valproic acid (VPA) is widely used for the treatment of epilepsy, migraine, and a variety of psychiatric conditions. The reported incidences of hyperammonemia induced by VPA use is variable.
Tressa McMorris, PharmD, BCPS +3 more
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Different types of hyperammonemia in clinical practice [PDF]
Медицинский совет, 2018 Hyperammonemia is a metabolic disorder, which is caused as a result of high levels of ammonia present in the blood. Hyperammonemia is related to severe liver diseases, primarily to cirrhosis in 90% of cases.
E. Yu. Plotnikova, A. S. Sukhikh
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A Case of Hyperammonemia Associated with High Dihydropyrimidine Dehydrogenase Activity [PDF]
Case Reports in Oncological Medicine, 2016 Over the past decades, 5-Fluorouracil (5-FU) has been widely used to treat several types of carcinoma, including esophageal squamous cell carcinoma. In addition to its common side effects, including diarrhea, mucositis, neutropenia, and anemia, 5-FU ...
Keiki Nagaharu +8 more
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Multiple Asparaginase Infusions Cause Increasingly Severe Acute Hyperammonemia
Medical Sciences, 2022 Adverse reactions during and shortly after infusing asparaginase for the treatment of acute lymphoblastic leukemia can increase in severity with later doses, limiting further use and increasing relapse risk.
Randal K Buddington +2 more
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Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase. [PDF]
PLoS ONE, 2018 Hyperammonemia is the common biochemical hallmark of urea cycle disorders, activating neurotoxic pathways. If untreated, affected individuals have a high risk of irreversible brain damage and mortality.
Matthias Zielonka +5 more
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Acute pediatric hyperammonemia: current diagnosis and management strategies
Hepatic Medicine: Evidence and Research, 2018 Nadia Savy,1 David Brossier,2 Catherine Brunel-Guitton,1 Laurence Ducharme-Crevier,1 Geneviève Du Pont-Thibodeau,1 Philippe Jouvet1 1Department of Pediatrics, CHU Sainte-Justine, University of Montreal, Montreal, QC, Canada; 2Department of ...
Savy N +5 more
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Hyperammonemia Post Lung Transplantation: A Review
Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, 2020 Hyperammonemia is the pathological accumulation of ammonia in the blood, which can occur in many different clinical settings. Most commonly in adults, hyperammonemia occurs secondary to hepatic dysfunction; however, it is also known to be associated with
Ksenia D Guvakova, Robert F Leger
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Molecular Genetics and Metabolism ReportsIntroduction: FBXL4- related encephalomyopathic mitochondrial DNA (mtDNA) depletion syndrome is caused by pathogenic variants in the FBXL4 gene, resulting in mitochondrial dysfunction and multisystem involvement.
Ayça Burcu Kahraman +4 more
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Impact of non-hepatic hyperammonemia on mortality in intensive care unit patients: a retrospective cohort study [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims The effect of hyperammonemia on the mortality in patients with liver cirrhosis is well documented. However, little is known about the impact of hyperammonemia on mortality among intensive care unit patients without hepatic disease.
Jae Heon Kim +8 more
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