Results 41 to 50 of about 9,393 (183)
Multiple myeloma with hyperammonemia.
Nihon Naika Gakkai Zasshi, 2000 症例は71歳男性. 1998年7月頃より食欲低下,全身倦怠感が出現し,当院受診.軽度の脱水を認め入院となった.入院後,突然昏睡状態となり,血中アンモニア294ug/dlと高アンモニア血症を認めた.入院時貧血と軽度の腰痛があったことより,骨髄腫を疑い骨髄穿刺を施行し,異型性のある形質細胞の増加とIgG-λ型M蛋白を認め骨髄腫と診断した.原因不明の高アンモニア血症の鑑別として貴重な症例と考えられた.
Horie, Atsuya +4 more
openaire +3 more sources
Hyperammonemia in Hepatic Encephalopathy [PDF]
Journal of Clinical and Experimental Hepatology, 2018 The precise mechanism underlying the neurotoxicity of Hepatic Encephalopathy (HE) is remains unclear. The dominant view has been that gut-derived nitrogenous toxins are not extracted by the diseased liver and thereby enter the brain. Among the various toxins proposed, the case for ammonia is most compelling.
A R, Jayakumar, Michael D, Norenberg
openaire +2 more sources
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objectives The objectives of this study were to develop a real‐world‐data (RWD) database for patients with epilepsy to provide further real‐world‐evidence (RWE) for monogenic genetic epilepsies; to assess the usefulness of a diagnostic algorithm in epilepsy; and to examine protein 3D structures using in silico tools to predict variant ...
Haley Morris +4 more
wiley +1 more source
Journal of Medical Case Reports, 2018 Background Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a rare inherited urea cycle disorder, can remain undiagnosed for decades and suddenly turn into an acute life-threatening state.
Thomas Silfverberg +4 more
doaj +1 more source
Topiramate-Related Hyperammonemia [PDF]
Journal of Pharmacy Technology, 2015 Objective: To report a case of hyperammonemia associated with the interaction between topiramate and valproic acid. Case Summary: We present a patient case with topiramate-related hyperammonemia. The patient was on topiramate prior to admission and presented with an elevated ammonia level following 2 doses of valproic acid.
Kelly, Moore +2 more
openaire +2 more sources
Diverting the Diagnosis: A Case Report of Hemodialysis Masking the Etiology of Hyperammonemia
Canadian Journal of Kidney Health and DiseaseRationale: Hyperammonemia in patients receiving hemodialysis is uncommon but poses a significant clinical challenge due to the effective clearance of ammonia by dialysis, which can obscure the underlying cause.
Adina Landsberg +3 more
doaj +1 more source
iLABMED, EarlyView.Hyperammonemic stress suppresses ACTA2 expression and induces F‐actin cytoskeletal remodeling in astrocytes. The resulting inhibition of FAK/c‐Src signaling contributes to apoptosis, G2/M arrest, AQP4‐mediated swelling and junction‐associated proteins dysregulation, revealing a central role for ACTA2‐dependent cytoskeletal dysfunction in hepatic ...
Yue Tang +6 more
wiley +1 more source
Prognostic Role of Ammonia in Critical Care Patients Without Known Hepatic Disease
Frontiers in Medicine, 2020 Background and Aims: Hyperammonemia usually develops because of hepatic disease, but it may occur in patients with non-hepatic hyperammonemia (NHH). But, studies on the prognosis and possible risk factors of this disorder are lacking.
Lina Zhao +7 more
doaj +1 more source
Renal replacement therapy in neonates with an inborn error of metabolism [PDF]
Korean Journal of Pediatrics, 2019 Hyperammonemia can be caused by several genetic inborn errors of metabolism including urea cycle defects, organic acidemias, fatty acid oxidation defects, and certain disorders of amino acid metabolism.
Heeyeon Cho
doaj +1 more source