Results 41 to 50 of about 12,857 (206)

The hyperornithinemia-hyperammonemia-homocitrullinuria syndrome [PDF]

, 2015
Hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome is a rare autosomal recessive disorder of the urea cycle. HHH has a panethnic distribution, with a major prevalence in Canada, Italy and Japan.
Fiermonte, G., Diodato, Daria, Boenzi, Sara, Martinelli, D., Ponzi, Emanuela, Carlo Dionisi-Vici, Martinelli, Diego, Ponzi, E., Dionisi Vici, C., Daria Diodato, Dionisi Vici, Carlo, Bertini, Enrico, Diego Martinelli, Enrico Bertini, Bertini, E., Magnus Monné, Emanuela Ponzi, Sara Boenzi, FIERMONTE, Giuseppe, Giuseppe Fiermonte, Monné, Magnus, MONNE', MAGNUS LUDVIG, Boenzi, S., Diodato, D.   +23 more
core   +1 more source

Valproic acid induced hyperammonemic encephalopathy: A case report (Turkish) [PDF]

Klinik Psikiyatri Dergisi, 2018
Valproic acid (VPA) is commonly used drug to treat variety of anticonvulsant and mood stabilizer in psychiatric and neurologic cases. It is thought to be a safe drug with a large therapeutic aspect..Uncommonly, hyperammonemia can be progressed by the
Ferda Apa, Figen Çulha Ateşci, Gülfizar Sözeri Varma   +2 more
doaj   +1 more source

Host and fungal factors both contribute to cryptococcosis-associated hyperammonemia (cryptammonia)

Microbiology Spectrum
Cryptococcus neoformans and Cryptococcus gattii are both known urease producers and have the potential to cause hyperammonemia. We hypothesized that the risk of hyperammonemia is increased by renal failure, burden of cryptococcal infection, and fungal ...
Rosanna P. Baker, Maria Schachter, Steven Phillips, Sheetal Kandiah, Mirza Farrque, Arturo Casadevall, Prem A. Kandiah   +6 more
doaj   +1 more source

Clinical practice: the management of hyperammonemia [PDF]

, 2010
Hyperammonemia is a life-threatening condition which can affect patients at any age. Elevations of ammonia in plasma indicate its increased production and/or decreased detoxification. The hepatic urea cycle is the main pathway to detoxify ammonia; it can
Johannes Häberle, Häberle, J, Häberle J   +2 more
core   +1 more source

The Pros & Cons of Measuring Plasma Ammonia in the Management of Patients With Cirrhosis: An ISHEN Debate [PDF]

Liver Int
ABSTRACT Ammonia is a nitrogenous molecule which is primarily generated in the gastrointestinal tract. The neurotoxicity of ammonia plays a critical role in the liver's regulation of circulating ammonia levels. In liver disease, an increase in blood ammonia has been long implicated in the pathogenesis of hepatic encephalopathy (HE), a neurological ...
Ballester M, Bloom P, Rose C.
europepmc   +2 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Hyperammonemia induces programmed liver cell death [PDF]

Hyperammonemia is common in liver cirrhosis and causally associated with hepatic encephalopathy development. Little is known about its hepatotoxic effects, which we aimed to characterize in this study.
Mehta, G., Otto, Tobias, Damink, S.O., Engelmann, C., Moreau, R., Jalan, R., Arroyo, V., Engelmann, Cornelius, Castelli, F., Brunet, Ludovic, Khetan, Varun U, Fenaille, François, Arroyo, Vicente, Trautwein, C., Chollet, Céline, Hassan, Mohsin, Volkert, I., Chollet, C., Kumar, P., Hall, A., Andreola, F., Kerbert, Annarein, J C, Qi, Tingting, Khetan, Varun, U, Hall, Andrew, Kerbert, A.J.C., Hassan, M., Qi, T.T., Castelli, Florence, Habtesion, A., Andreola, Fausto, Moreau, Richard, Coenraad, Minneke, J, Mehta, Gautam, Jalan, Rajiv, Trautwein, Christian, Aguilar, F., Habtesion, Abeba, Brunet, L., Kerbert, Annarein J C, Olde Damink, Steven; id_orcid, Olde Damink, Steven, Aguilar, Ferran, Clària, Joan, Khetan, V.U., Coenraad, Minneke J, Clària, J., Coenraad, M.J., Kumar, Pavitra, Volkert, Ines, Otto, T., Fenaille, F., Khetan, Varun U., Kerbert, Annarein J.C., Coenraad, Minneke J.   +54 more
core   +1 more source

Measuring Blood Plasma Glutamine Levels Using a Nanopore‐Based Sensor

Advanced Healthcare Materials, EarlyView.
Glutamine (GLN) is a biomarker useful for predicting toxic ammonia accumulation. Here, we used a biosensor based on the Cytolysin A (ClyA) nanopore coupled with the GLN‐specific protein substrate‐binding domain 2 (SBD2) to demonstrate real‐time measurement of GLN in blood plasma, highlighting the potential for future point‐of‐care applications ...
Sofia B. Relvas, Iris M. Kormelink, Sandra Michel‐Souzy, Florian L. R. Lucas, Nieck J. van der Heide, Hans R. Waterham, Ramon Versteeg, Judith Jans, Loes I. Segerink, Carsten Wloka   +9 more
wiley   +1 more source

Hyperammonemia: What Urea-lly Need to Know: Case Report of Severe Noncirrhotic Hyperammonemic Encephalopathy and Review of the Literature

Case Reports in Medicine, 2016
Purpose. A 66-year-old man who presented with coma was found to have isolated severe hyperammonemia and diagnosed with a late-onset urea-cycle disorder. He was treated successfully and had full recovery. Methods.
Ruby Upadhyay, Thomas P. Bleck, Katharina M. Busl   +2 more
doaj   +1 more source

Therapy of hyperammonemia

EXCLI journal, 2015
EXCLI Journal;Vol.
openaire   +3 more sources