Results 51 to 60 of about 12,857 (206)
Investigation of Novel Therapies for Hyperammonemia [PDF]
, 2019 Ammonia is a toxic compound daily produced and consumed during cell metabolism in the body. It is converted to the less toxic substance urea by the urea cycle in the liver.
de Angelis, Angela
core +1 more source
Diagnostics, 2023 Hyperammonemia can lead to encephalopathy and may be accompanied by a diagnostic dilemma. Imaging as well as biochemical analyses are the cornerstone for identifying possible underlying causes such as severe liver disease or urea cycle defect.
Marcel Zorgdrager +2 more
doaj +1 more source
Multiple myeloma with hyperammonemia.
Nihon Naika Gakkai Zasshi, 2000 症例は71歳男性. 1998年7月頃より食欲低下,全身倦怠感が出現し,当院受診.軽度の脱水を認め入院となった.入院後,突然昏睡状態となり,血中アンモニア294ug/dlと高アンモニア血症を認めた.入院時貧血と軽度の腰痛があったことより,骨髄腫を疑い骨髄穿刺を施行し,異型性のある形質細胞の増加とIgG-λ型M蛋白を認め骨髄腫と診断した.原因不明の高アンモニア血症の鑑別として貴重な症例と考えられた.
Horie, Atsuya +4 more
openaire +3 more sources
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Idiopathic hyperammonemia in a ten-year-old Quarter Horse
, 2010 A ten-year-old quarter horse mare presented to Cornell University’s Equine and Farm Animal Hospital in September of 2009. The mare had a one-day history of colic signs.
Russo, Kay
core +5 more sources
Topiramate-Related Hyperammonemia [PDF]
Journal of Pharmacy Technology, 2015 Objective: To report a case of hyperammonemia associated with the interaction between topiramate and valproic acid. Case Summary: We present a patient case with topiramate-related hyperammonemia. The patient was on topiramate prior to admission and presented with an elevated ammonia level following 2 doses of valproic acid.
Kelly, Moore +2 more
openaire +2 more sources
Role of carglumic acid in the treatment of acute hyperammonemia due to N-acetylglutamate synthase deficiency [PDF]
, 2011 N-acetylglutamate synthase (NAGS) deficiency is a rare inborn error of metabolism affecting ammonia detoxification in the urea cycle. The product of NAGS is N-acetylglutamate which is the absolutely required allosteric activator of the first urea cycle ...
Häberle J +3 more
core +1 more source
iNew Medicine, EarlyView.This study demonstrates that the model for end‐stage liver disease (MELD) score significantly underestimates 90‐day mortality in acute‐on‐chronic liver failure (ACLF) patients (AUC: 0.556) compared to non‐ACLF patients (area under the receiver operating characteristic curve [AUC]: 0.848).
Guanghou Chen +5 more
wiley +1 more source
Journal of Medical Case Reports, 2018 Background Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a rare inherited urea cycle disorder, can remain undiagnosed for decades and suddenly turn into an acute life-threatening state.
Thomas Silfverberg +4 more
doaj +1 more source
Hyperammonemia in Hepatic Encephalopathy [PDF]
Journal of Clinical and Experimental Hepatology, 2018 The precise mechanism underlying the neurotoxicity of Hepatic Encephalopathy (HE) is remains unclear. The dominant view has been that gut-derived nitrogenous toxins are not extracted by the diseased liver and thereby enter the brain. Among the various toxins proposed, the case for ammonia is most compelling.
A R, Jayakumar, Michael D, Norenberg
openaire +2 more sources