Results 211 to 220 of about 59,957 (280)

Iso‐ and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On‐Target Activity Through Scaffold Decoration and In Situ Warhead Generation

open access: yesChemMedChem, Volume 21, Issue 16, 27 August 2026.
We explore covalent allosteric targeting of MGL regulatory cysteines using iso‐ and benzisothiazolinone scaffolds. Combining mechanism‐based warhead release with structure‐guided scaffold decoration to improve molecular recognition, this study probes strategies to achieve selective on‐target engagement beyond the catalytic site. Monoacylglycerol lipase
Edoardo Rocca   +12 more
wiley   +1 more source

Evaluation of Novel Isatin–Schiff Base Derivatives: Monoamine Oxidase Inhibition and Antimicrobial Assessment

open access: yesChemMedChem, Volume 21, Issue 16, 27 August 2026.
Five novel series of isatin–Schiff base derivatives are synthesized and evaluated for neuroprotective and anti‐infective potential. The compounds demonstrate exceptional, reversible, and competitive monoamine oxidase inhibition, with chloro‐substitutions dictating isoform selectivity.
Marthinus J. Jooste   +4 more
wiley   +1 more source

Engineering <i>Escherichia coli</i> for Urease-Driven Synthesis of Metal Oxide Nanomaterials. [PDF]

open access: yesACS Synth Biol
Wu ZY   +6 more
europepmc   +1 more source

Contrasting effects of mineral, farmyard manure, and integrated fertilization on soybean productivity, seed quality, and soil biochemical properties. [PDF]

open access: yesBMC Plant Biol
Ramazanoglu E   +8 more
europepmc   +1 more source

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