Results 111 to 120 of about 9,061,852 (330)

Acute kidney injury due to bilateral ureteral obstruction in children.

World Journal of Nephrology, 2014
Bilateral ureteral obstruction in children is a rare condition arising from several medical or surgical pictures. It needs to be promptly suspected in order to attempt a quick renal function recovery.
D. Bianchi, G. Vespasiani, P. Bove
semanticscholar   +1 more source

FGFR2/3 Gene Alterations and Clinical Outcomes in Advanced/Metastatic Urothelial Cancer in Japan: MONSTAR‐SCREEN Database Study

Cancer Science, Volume 116, Issue 5, Page 1424-1432, May 2025.
Fibroblast growth factor receptor (FGFR) gene alterations (GAs) are known as driver genes for urothelial cancer (UC); however, the proportion of UC genetic panel testing in Japan remains low. In this Japanese database study, we clarified that one of the eight patients had FGFR2/3 GAs in advanced/metastatic UC.
Nobuaki Matsubara, Takahiro Osawa, Takashige Abe, Mototsugu Oya, Koshiro Nishimoto, Toshiyuki Iwahori, Hiroaki Tsuchiya, Maiko Murota, Masaki Yoshida, Yohei Tatematsu, Yosuke Nakano, Masatoshi Eto, Norio Nonomura   +12 more
wiley   +1 more source

DomainScope: A disease network based on protein domain connections [PDF]

arXiv, 2019
Protein domains are highly conserved functional units of proteins. Because they carry functionally significant information, the majority of the coding disease variants are located on domains. Additionally, domains are specific units of the proteins that can be targeted for drug delivery purposes.
arxiv  

IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target

Cell Proliferation, EarlyView.
IMPDH2 is a rate‐limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We
Zheng Li, Yunpeng Zou, Jiayao Niu, Ying Zhang, Aohua Yang, Wenyu Lin, Jie Guo, Shuya Wang, Ronghan Liu   +8 more
wiley   +1 more source

Recent advances in minimally invasive colorectal cancer surgery [PDF]

, 2002
Laparoscopy has improved surgical treatment of various diseases due to its limited surgical trauma and has developed as an interesting therapeutic alternative for the resection of colorectal cancer.
Angele, M. K., Meyer, G., Rau, H. G., Schildberg, Friedrich Wilhelm, Wichmann, Mathias W.   +4 more
core   +1 more source

Replacement of extended ureteral strictures in children: a multicenter experience with appendicoplasty

Вестник урологии
Introduction. The first description of ureteral appendicoplasty was provided by the Italian surgeon Giannettasio in 1901, followed by two German surgeons, Franke and Rydygier. Their work was later included in a review by Melnikoff in 1912. However, it is
I. M. Kagantsov, K. I. Pelikh, V. I. Dubrov, V. V. Sizonov, O. S. Shmyrov, E. A. Kontratyeva   +5 more
doaj   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Safety and Efficacy of Long‐Term Treatment of Type 1 Plasminogen Deficient Patients With Intravenous Plasminogen Replacement Therapy

Haemophilia, EarlyView.
ABSTRACT Introduction Type 1 plasminogen deficiency (PLGD‐1), or hypoplasminogenaemia, is an ultra‐rare autosomal‐recessive disorder characterised by fibrin‐rich lesions on mucous membranes, often leading to serious complications if left untreated. Prior treatments have shown limited and inconsistent success, but IV PLG concentrate (Ryplazim) offers a ...
Amy D. Shapiro, Heather McDaniel, Robert W. Decker, Charles Nakar, Jeremy Lorber, Neelam Thukral, Joseph M. Parker, Karen Thibaudeau   +7 more
wiley   +1 more source

Time series analysis of Parkinson's disease, Huntington's disease and Amyotrophic Lateral Sclerosis [PDF]

arXiv, 2013
The aim of this paper is to study the (clinical) time-series data of three diseases with complex dynamics: Parkinson's disease, Huntington's disease and Amyotrophic Lateral Sclerosis. For this purpose, first all of the time series data are embedded in a vector space of suitable dimension and then the correlation dimension of the above mentioned ...
arxiv  

Analysis of the human diseasome reveals phenotype modules across common, genetic, and infectious diseases [PDF]

, 2014
Phenotypes are the observable characteristics of an organism arising from its response to the environment. Phenotypes associated with engineered and natural genetic variation are widely recorded using phenotype ontologies in model organisms, as are signs and symptoms of human Mendelian diseases in databases such as OMIM and Orphanet.
arxiv   +1 more source