Results 81 to 90 of about 25,212 (201)

Methotrexate Toxicity in a Patient With Renal Failure Despite a Normal Methotrexate Concentration: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Methotrexate (MTX) is a folate antagonist widely used as a disease‐modifying antirheumatic drug (DMARD) in rheumatoid arthritis (RA), as well as in several malignancies and autoimmune disorders. Although low‐dose MTX (5–20 mg/week) is generally considered safe, it has a narrow therapeutic index, and toxicity can occur even at therapeutic doses,
Fatemeh Afra, Mahshad Ghoddusi, Mahsa Mottahedi, Maryam Albaji, Samira Kafan, Roya Saedpanah, Amir Shokri, Elham Nazar   +7 more
wiley   +1 more source

Towards Clinical Translation of Intravoxel Incoherent Motion MRI: Acquisition and Analysis Consensus Recommendations

Journal of Magnetic Resonance Imaging, Volume 63, Issue 6, Page 1782-1801, June 2026.
ABSTRACT Intravoxel incoherent motion (IVIM) MRI allows for simultaneous assessment of tissue microcirculation (perfusion) and diffusion of water. In single‐center studies, IVIM has shown great potential for diagnosis, treatment outcome prediction, and treatment monitoring for many different diseases and organs.
Eric E. Sigmund, Susanne S. Rauh, Mami Iima, Christian Federau, Diego Hernando, Oscar Jalnefjord, Jacobus F. A. Jansen, Jonas Jasse, Neil Peter Jerome, Misha P. T. Kaandorp, Sila Kurugol, Frederik B. Laun, Mira M. Liu, Alexandra Ljimani, Thoralf Niendorf, David A. Reiter, Mohammed Salman Shazeeb, Amita Shukla‐Dave, Julia Stabinska, Andreas Wetscherek, Peter T. While, Dan Wu, Denis Le Bihan, Oliver J. Gurney‐Champion   +23 more
wiley   +1 more source

Exploring hemodynamic alterations in gastroschisis: insights into fetal growth restriction using prenatal MRI

Ultrasound in Obstetrics &Gynecology, Volume 67, Issue 6, Page 795-805, June 2026.
Abstract Objective Despite the high incidence of fetal growth restriction (FGR) in gastroschisis (GS) associated with placental fetal vascular malperfusion (FVM), the underlying mechanism remains unclear. We aimed to investigate whether umbilical vein (UV) stenosis at the abdominal wall defect impairs fetoplacental circulation, leading to FGR.
H. Shi, D. Prayer, P. Kienast, R. Stepponat, C. Mitter, J. Tischer, X. Li, J. Binder, G. Kasprian   +8 more
wiley   +1 more source

Tc99m-DTPA Study to Validate an Experimental Model of Ureteral Obstruction in Rabbits: Preliminary Results

Advances in Urology, 2013
Objective. To create a ureteral obstruction experimental model that can be proved through Tc99m-DTPA renal scintigraphy and histopathological studies, without causing total renal function loss. Materials and Methods.
Marcelo Lopes de Lima, Rodolfo Bertti, Juliano César Moro, Fábio Coltro Neto, Ricardo Miyaoka, Adriano Fregonesi, Mariana da Cunha Lopes de Lima, Celso Darío Ramos   +7 more
doaj   +1 more source

Tubular Omega‐3 Fatty Acid Receptor FFAR4 Deficiency Aggravated Renal Aging and Chronic Kidney Disease

Aging Cell, Volume 25, Issue 6, June 2026.
This study illustrates that omega‐3 PUFAs with their receptor FFAR4 alleviate tubular senescence and fibrosis in aged and fibrotic kidneys. Furthermore, we indicate that tubular FFAR4 improves renal senescence via 15d‐PGJ2‐PPARγ‐Klotho signaling, and suppresses kidney fibrosis by senescent tubular cell‐driven fibroblast activation.
Letian Yang, Lei Tang, Jian Li, Dekai Liu, Chunchun Hu, Fan Guo, Lin Lin, Rongshuang Huang, Ping Fu, Liang Ma   +9 more
wiley   +1 more source

Successful Treatment of Obstructive Ureterolithiasis with Medical Expulsive Therapy Including Tamsulosin in a Dog

Veterinary Sciences
Ureterolithiasis is a common cause of ureteral obstruction in dogs, often leading to kidney injury. Medical expulsive therapy (MET) using α-adrenergic antagonists has been proposed as a nonsurgical treatment option in selected cases and is thought to ...
Chaeyeon Park, Yelim Lee, Yeon Chae, Taesik Yun, Byeong-Teck Kang, Hakhyun Kim   +5 more
doaj   +1 more source

Histopathological Assessment of Precision‐Cut Kidney Slices: A Live Human Tissue‐Based Model of Renal Fibrosis

APMIS, Volume 134, Issue 6, June 2026.
ABSTRACT Chronic kidney disease (CKD) is characterized by a progressive decline of renal function. A major challenge in CKD drug development is the low success rate of drug candidates, with fewer than 10% of drugs entering Phase I clinical trials demonstrating clinical benefit.
Andreas Riishede, Camilla Merrild, Seulgi Hyun, Mia G. Madsen, Anna K. Keller, Henricus A. M. Mutsaers, Rikke Nørregaard, Lene N. Nejsum   +7 more
wiley   +1 more source

Successful ureteral stent placement with rendezvous technique for ureteral obstruction after urinary diversion: A case report

Radiology Case Reports
Ureteral obstruction after urinary diversion is not a rare complication, and the treatment is generally the ureteral stent placement via antegrade approach via the nephrostomy.
Mariko Irizato, MD, Yozo Sato, MD, Shinichi Murata, MD, Shohei Chatani, MD, Akira Ouchi, MD, Takashi Kinoshita, MD, Hidekazu Yamaura, MD, Yoshitaka Inaba, MD   +7 more
doaj   +1 more source

A minor high‐grade component in non‐invasive papillary urothelial carcinoma is not associated with a more indolent behaviour

Histopathology, Volume 88, Issue 7, Page 1430-1442, June 2026.
Non‐invasive papillary urothelial carcinomas with minor high‐grade component are not associated with a more indolent behavior and should likely be regarded as high‐grade carcinomas. Aims The latest WHO edition proposed using a cut‐off of ≥5% high‐grade component (%HGc) as a criterion to label non‐invasive papillary urothelial carcinomas as high‐grade ...
Mina S. Farag, Neda Oghbaei, Jaffar Hussain, André Lametti, Wassim Kassouf, Fadi Brimo   +5 more
wiley   +1 more source

Updates on the use of ureteral stents: focus on the Resonance® stent

Medical Devices: Evidence and Research, 2010
Manoj V Rao, Anthony J Polcari, Thomas MT TurkDepartment of Urology, Loyola University Medical Center, Maywood, IL, USAAbstract: The Resonance® metallic ureteral stent is one of the latest additions to the urologist’s armamentarium in ...
Thomas MT Turk, Anthony J Polcari, Manoj V Rao   +2 more
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