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The effect of polymorphism of uric acid transporters on uric acid transport

Journal of Nephrology, 2018
Abstract The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on. Serum uric acid levels are maintained by the balance between production and elimination.
Fang Zhao, Rui Liu, Weidang Wu
exaly   +3 more sources

Uric acid and the kidney

Pediatric Nephrology, 2013
Uric acid, the end product of purine metabolism, is excreted predominantly by the proximal tubules. Abnormal serum levels of uric acid are due to alterations in production or excretion. Fractional excretion of uric acid is helpful in determining the underlying etiology of hypouricemia or hyperuricemia in children.
Sahar A, Fathallah-Shaykh   +1 more
openaire   +2 more sources

Uric Acid and Kidney

1989
Uric acid is the end product of purine metabolism in humans. In animals other than mammals uric acid undergoes further degradation because of the activity of enzymes such as uricase, allantoinase and allantoinase; in some species the urea that is formed is further hydrolyzed to ammonia and CO2 by the urease of intestinal bacteria (1).
Fuiano G   +3 more
openaire   +5 more sources

Uric Acid Nephrolithiasis

Urologic Clinics of North America, 2007
Uric acid nephrolithiasis may be the final manifestation of various pathophysiological processes. Recent advances in renal urate transport have elucidated mechanisms by which hyperuricosuria occurs. However, in most uric acid stone formers the primary pathophysiologic defect is an excessively acidic urine pH rather than hyperuricosuria.
Mary Ann, Cameron, Khashayar, Sakhaee
openaire   +4 more sources

Uric acid and the vasculature

Current Hypertension Reports, 2006
Hyperuricemia is a frequent finding in diseases in which the clinical manifestations are thought to be secondary to a state of generalized vascular endothelial dysfunction and related to the cardiovascular disease present in conditions associated with the metabolic syndrome, such as hypertension or diabetes.
Dalila B, Corry, Michael L, Tuck
openaire   +2 more sources

Uric Acid Excretion

Annals of Internal Medicine, 1979
Excerpt To the editor: The article by Simkin and associates in the July issue (1) discussed a common problem in clinical medicine and provoked much conversation among the physicians here.
C, Greenberg, B K, Jayaswal
openaire   +2 more sources

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