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Current Hypertension Reports, 2006
Hyperuricemia is a frequent finding in diseases in which the clinical manifestations are thought to be secondary to a state of generalized vascular endothelial dysfunction and related to the cardiovascular disease present in conditions associated with the metabolic syndrome, such as hypertension or diabetes.
Dalila B, Corry, Michael L, Tuck
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Hyperuricemia is a frequent finding in diseases in which the clinical manifestations are thought to be secondary to a state of generalized vascular endothelial dysfunction and related to the cardiovascular disease present in conditions associated with the metabolic syndrome, such as hypertension or diabetes.
Dalila B, Corry, Michael L, Tuck
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1989
Uric acid is the end product of purine metabolism in humans. In animals other than mammals uric acid undergoes further degradation because of the activity of enzymes such as uricase, allantoinase and allantoinase; in some species the urea that is formed is further hydrolyzed to ammonia and CO2 by the urease of intestinal bacteria (1).
Fuiano G +3 more
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Uric acid is the end product of purine metabolism in humans. In animals other than mammals uric acid undergoes further degradation because of the activity of enzymes such as uricase, allantoinase and allantoinase; in some species the urea that is formed is further hydrolyzed to ammonia and CO2 by the urease of intestinal bacteria (1).
Fuiano G +3 more
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Pediatric Nephrology, 2013
Uric acid, the end product of purine metabolism, is excreted predominantly by the proximal tubules. Abnormal serum levels of uric acid are due to alterations in production or excretion. Fractional excretion of uric acid is helpful in determining the underlying etiology of hypouricemia or hyperuricemia in children.
Sahar A, Fathallah-Shaykh +1 more
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Uric acid, the end product of purine metabolism, is excreted predominantly by the proximal tubules. Abnormal serum levels of uric acid are due to alterations in production or excretion. Fractional excretion of uric acid is helpful in determining the underlying etiology of hypouricemia or hyperuricemia in children.
Sahar A, Fathallah-Shaykh +1 more
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Current Opinion in Nephrology and Hypertension, 2003
The goal of this article is to review the physiology and describe newly defined molecular mechanisms that are responsible for renal urate transport.Four complementary DNAs have recently been cloned whose expressed proteins transport urate. Two of these proteins have been localized to the apical membrane of proximal tubular cells: one, a urate ...
Mohammed A, Rafey +3 more
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The goal of this article is to review the physiology and describe newly defined molecular mechanisms that are responsible for renal urate transport.Four complementary DNAs have recently been cloned whose expressed proteins transport urate. Two of these proteins have been localized to the apical membrane of proximal tubular cells: one, a urate ...
Mohammed A, Rafey +3 more
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Seminars in Nephrology, 2011
Hyperuricemia is a common complication in organ transplant recipients, with a higher incidence in kidney and heart recipients. Risk factors for post-transplant hyperuricemia include reduced glomerular filtration rate, diuretic use, cyclosporine therapy, increasing age at transplant, obesity, and metabolic syndrome, as well as the presence of ...
Fernanda Cristina, Mazali +1 more
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Hyperuricemia is a common complication in organ transplant recipients, with a higher incidence in kidney and heart recipients. Risk factors for post-transplant hyperuricemia include reduced glomerular filtration rate, diuretic use, cyclosporine therapy, increasing age at transplant, obesity, and metabolic syndrome, as well as the presence of ...
Fernanda Cristina, Mazali +1 more
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Current Hypertension Reports, 2006
Epidemiologic studies published during the past 3 years support the possible role of uric acid in the onset of essential hypertension. Data from several large, longitudinal cardiovascular disease studies indicate that elevated serum uric acid is a predictor of incident hypertension and blood pressure progression.
Daniel I, Feig +4 more
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Epidemiologic studies published during the past 3 years support the possible role of uric acid in the onset of essential hypertension. Data from several large, longitudinal cardiovascular disease studies indicate that elevated serum uric acid is a predictor of incident hypertension and blood pressure progression.
Daniel I, Feig +4 more
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Seminars in Nephrology, 2005
Increased uric acid level is a key clinical feature of preeclampsia; higher levels correlate with significant maternal and fetal morbidity and mortality. The cause of hyperuricemia and its specific role in the pathogenesis of preeclampsia, however, remain unclear.
Chun, Lam +3 more
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Increased uric acid level is a key clinical feature of preeclampsia; higher levels correlate with significant maternal and fetal morbidity and mortality. The cause of hyperuricemia and its specific role in the pathogenesis of preeclampsia, however, remain unclear.
Chun, Lam +3 more
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Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2015
Nephrolithiasis is a common condition in the general population. About 5-10% of all kidney stones is composed of uric acid, however the prevalence of uric acid stones significantly increases among patients with obesity, diabetes or metabolic syndrome.
Ferraro, Pietro Manuel +1 more
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Nephrolithiasis is a common condition in the general population. About 5-10% of all kidney stones is composed of uric acid, however the prevalence of uric acid stones significantly increases among patients with obesity, diabetes or metabolic syndrome.
Ferraro, Pietro Manuel +1 more
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The effect of polymorphism of uric acid transporters on uric acid transport
Journal of Nephrology, 2018The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on. Serum uric acid levels are maintained by the balance between production and elimination. There are many factors that maintain the balance of serum uric acid.
Ze Wang +9 more
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Seminars in Nephrology, 2005
Hyperuricemia is a common complication in organ transplant recipients, and frequently is associated with chronic cyclosporine immunosuppressive therapy. Kidney and heart transplant recipients are prone to develop posttransplant hyperuricemia. Risk factors for hyperuricemia include decreased glomerular filtration rate (GFR), diuretic use, and ...
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Hyperuricemia is a common complication in organ transplant recipients, and frequently is associated with chronic cyclosporine immunosuppressive therapy. Kidney and heart transplant recipients are prone to develop posttransplant hyperuricemia. Risk factors for hyperuricemia include decreased glomerular filtration rate (GFR), diuretic use, and ...
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