Results 261 to 270 of about 96,688 (309)

Induced Reoxidation and Reactivation of a Reduced Uridine Diphosphate Galactose-4-epimerase Complex

, 1974
Timple G. Wee, Perry A. Frey
openalex   +1 more source

Uridine, a Therapeutic Nucleoside, Exacerbates Alcoholic Liver Disease via SRC Kinase Activation: A Network Toxicology and Molecular Dynamics Perspective. [PDF]

Int J Mol Sci
Liu Z, Wang Z, Wang J, Xu S, Zhang T.
europepmc   +1 more source

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Uridine diphosphate glucuronosyltransferase 1A1

Xenobiotica, 2019
The role that the phase-II reaction, glucuronidation, plays in the biotransformation of endo and xenobiotics is discussed with particular emphasis given to the UGT1A1 isoenzyme.
G. Steventon
semanticscholar   +4 more sources

Posttranscriptional regulation of uridine diphosphate glucuronosyltransferases [PDF]

Expert Opinion on Drug Metabolism & Toxicology, 2015
The uridine diphosphate (UDP)-glucuronosyltransferase (UGT) superfamily of enzymes (EC 2.4.1.17) conjugates glucuronic acid to an aglycone substrate to make them more polar and readily excreted. In general, this reaction terminates the activities of chemicals, drugs and toxins, although occasionally a more active or toxic species is produced.In ...
Z. Riches, A. Collier
semanticscholar   +3 more sources

Enhancing Glycosylation of Flavonoids by Engineering the Uridine Diphosphate Glucose Supply in Escherichia coli.

Journal of Agricultural and Food Chemistry, 2023
Glycosylation can enhance the solubility and stability of flavonoids. The main limitation of the glycosylation process is low intracellular uridine diphosphate glucose (UDPG) availability.
Shike Liu, Dong Li, Zhijie Qin, Weizhu Zeng, Jingwen Zhou   +4 more
semanticscholar   +1 more source

Case report of sacituzumab govitecan-hziy-induced neutropenia in a patient with metastatic triple-negative breast cancer and a uridine diphosphate glucuronosyltransferase family 1 member A1 poor metabolizer genotype

Journal of Oncology Pharmacy Practice, 2021
Introduction Sacituzumab govitecan-hziy, approved in 2020 for treatment of metastatic triple-negative breast cancer, provides a new option for a population with a historically poor prognosis with standard chemotherapy.
Grace Baek, Lindsey Jung, Arianne Duong, J. Gralow   +3 more
semanticscholar   +1 more source

Preparation of uridine diphosphogalactose and uridine diphosphate

Analytical Biochemistry, 1964
Abstract A procedure for the production of UDP-Gal and UDP on a preparative scale has been elaborated using a bacterial mutant which accumulates UDP-Gal in the presence of galactose. This method provides several possibilities for labeling these compounds with radioactive isotopes.
H.A. Boye, Steven E. Brenner, A.E. Shedlovsky   +2 more
openaire   +3 more sources

A Practical and High-Affinity Fluorescent Probe for Uridine Diphosphate Glucuronosyltransferase 1A1: A Good Surrogate for Bilirubin.

Journal of Medicinal Chemistry, 2017
This study aimed to develop a practical and high-affinity fluorescent probe for uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), a key conjugative enzyme responsible for the elimination and detoxification of many potentially harmful compounds ...
X. Lv, Lei Feng, Chunzhi Ai, J. Hou, Ping Wang, Li-Wei Zou, Jie Cheng, Guangbo Ge, Jingnan Cui, Ling Yang   +9 more
semanticscholar   +1 more source

Chemoenzymatic Synthesis of 4-Fluoro-N-Acetylhexosamine Uridine Diphosphate Donors: Chain Terminators in Glycosaminoglycan Synthesis.

Journal of Organic Chemistry, 2017
Unnatural uridine diphosphate (UDP)-sugar donors, UDP-4-deoxy-4-fluoro-N-acetylglucosamine (4FGlcNAc) and UDP-4-deoxy-4-fluoro-N-acetylgalactosamine (4FGalNAc), were prepared using both chemical and chemoenzymatic syntheses relying on N-acetylglucosamine-
Victor L. Schultz, Xing Zhang, Kathryn Linkens, Jenna Rimel, Dixy E. Green, P. DeAngelis, R. Linhardt   +6 more
semanticscholar   +1 more source