Bioprinted Constructs in the Regulatory Landscape: Current State and Future Perspectives
Bioprinting has rapidly emerged as a transformative technology in biomedical research, offering unprecedented potential to replicate complex tissues. Despite its promise, clinical translation remains limited due to regulatory hurdles. This review explores global regulatory frameworks, comparing approaches in the EU, U.S., China, and Australia, and ...
Francesca Perin +6 more
wiley +1 more source
Advances in Optical Techniques for Tumor Detection
Cancer detection is vital for patient survival. Optical technologies overcome conventional cytology's limitations with high sensitivity and molecular specificity. This review highlights five techniques: Raman spectroscopy, fluorescence sensors, fiber optic sensors, photoacoustic imaging, and colorimetric detection for tumor diagnosis via direct ...
Yang Yu +6 more
wiley +1 more source
A novel research definition of bladder health in women and girls: Implications for research and public health promotion [PDF]
BACKGROUND:Bladder health in women and girls is poorly understood, in part, due to absence of a definition for clinical or research purposes. This article describes the process used by a National Institutes of Health funded transdisciplinary research ...
Amanda Berry +15 more
core +2 more sources
Advanced Microfluidics for Single Cell‐Based Cancer Research
Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro +10 more
wiley +1 more source
The Expression and Regulation of Chemokines (CXCL9, CXCL10, CXCL11) in Urinary Bladder Inflammation of the Mouse [PDF]
Interstitial cystitis is a serious chronic condition that causes bladder pain and increased voiding frequency in millions of adults in the US, most of them women.
Guo, Michael
core +1 more source
Actinomycosis of the urinary bladder
Actinomycosis of the urinary bladder is a rare anaerobic bacterial infection caused by Actinomyces isrealii. Initial diagnosis is often difficult and this disease is easily misdiagnosed as a urothelial or urachal tumour. The definitive diagnosis is usually made postoperatively via tissue pathology. We discuss a case of a 54-year-old male with a smoking
Chun Huang, Turki Al-Essawi
openaire +4 more sources
This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li +11 more
wiley +1 more source
Integrated ‘Shield‐Spear’ Biological Patch for Fibrosis‐Free Bladder Reconstruction
Fibrosis‐free bladder reconstruction remains challenging. This study pioneers an integrated “shield‐spear” patch: The outer anionic hydrogel layer captures GATA6+ macrophages to suppress collagen overexpression, while the inner S100 aptamer‐engineered EVs target Schwann cells to downregulate the TGFβ/Smad pathway—inhibiting fibrosis with enhanced wound
Xiaoqi Wu +14 more
wiley +1 more source
A 49-year-old woman presenting with hepatoid adenocarcinoma of the urinary bladder: a case report
Introduction Adenocarcinomas represent less than 2 percent of all urothelial neoplasms. Hepatoid adenocarcinoma is rare in the urinary bladder. Pathological diagnosis is based on a combination of histological features resembling hepatocellular carcinoma ...
Sekino Yohei +2 more
doaj +1 more source
Impacts of chronic stress on urinary bladder function & recovery through modification of PACAP signaling [PDF]
Stress can cause or contribute to bladder dysfunction though specific effects remain unclear. Individuals with interstitial cystitis (IC)/bladder pain syndrome (BPS) experience increased symptom severity with stress, including pain and increased urgency ...
Mathews, Morgan E
core +1 more source

