Results 61 to 70 of about 2,596,680 (296)
Neurogenic Defects Occur in LRIG2-Associated Urinary Bladder Disease
Kidney International Reports, 2023 Urofacial, or Ochoa, syndrome (UFS) is an autosomal recessive disease featuring a dyssynergic bladder with detrusor smooth muscle contracting against an undilated outflow tract. It also features an abnormal grimace. Half of individuals with UFS carry biallelic variants in HPSE2, whereas other rare families carry variants in LRIG2.LRIG2 is ...Grenier, Celine, Lopes, Filipa M., Cueto-González, Anna M., Rovira-Moreno, Eulàlia, Gander, Romy, Jarvis, Benjamin W., McCloskey, Karen D., Gurney, Alison M., Beaman, Glenda M., Newman, William G., Woolf, Adrian S., Roberts, Neil A. +11 moreopenaire +5 more sourcesMitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase
Advanced Science, EarlyView.An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang +18 morewiley +1 more sourceTargeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer
Advanced Science, EarlyView.A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong +15 morewiley +1 more sourceSummary of the 2023 report of the international consultation on incontinence interstitial cystitis/bladder pain syndrome (IC/BPS) committee
Continence, 2023 Interstitial cystitis and bladder pain syndrome are essentially interchangeable as there is no accepted definition that clearly delineates the interstitial cystitis syndrome from bladder pain syndrome.Philip Hanno, Mauro Cervigni, Myung Soo Choo, J. Quentin Clemens, Ming-Huei Lee, Sachin Malde, Jane Meijlink, Michael Samarinas, Tomohiro Ueda, Daniela Gold +9 moredoaj +1 more sourceA multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci [PDF]
, 2010 We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which ...Taylor JA, Diver WR, Vermeulen, Sita H, Xifeng Wu, Allione A, Hildebrandt, MA, Hengstler JG, Besenbacher, S, Godfrey, A., Trichopoulos D, Tjonneland A, Teo MT, Nuria Malats, Koppova, Kvetoslava, Panico, S, Malcolm C Pike, Albanes, D, Prokunina-Olsson, L, Riboli, E., Baris, D, Yeager, M, Dietrich, H., Kiltie, Anne, Xu, Z, Kiemeney L, Benhamou, Simone, Allen, Naomi E, Vineis P, Fletcher T, Yuan J, Knowles, M.A., Silverman, DT, Taylor, JA, Alan Schned, Bishop, DT, Manolis Kogevinas, Mark T W Teo, Xu Z, Lloreta, J., Hutchinson A, Sanz-Velez JI, Colin P Dinney, Wheeler, William, Francisco X Real, Fletcher, T, Godfrey, Ashley, Valdivia G, Matullo, Giuseppe, Fraumeni, Joseph F, Klaus Golka, Cancel-Tassin, Geraldine, Czerniak, B., Stefansson, K, Peter Rudnai, Federico Canzian, Czerniak, Bogdan, Thun M, McGrath, Monica, Gago-Dominguez, M., Clavel-Chapelon, F, Sanchez, Manuel, Gago-Dominguez, M, Panico S, Sulem P, Chanock, Stephen J, McGrath M, Lloreta, Josep, 1958-, Mayordomo, Jose I, Dinney, Colin P, Vineis, Paolo, Ljungberg, Borje, Weinstein, SJ, Real, FX, Chatterjee N, Olivier Cussenot, H Bas Bueno-de-Mesquita, Kumar, Rajiv, Xu, Z., Tony Fletcher, Hushan Yang, Bueno-De-Mesquita, HB, Hildebrandt, M.A.T., Rothman N, Chen, Meng, Naomi E Allen, Jacobs EJ, Albanes, Demetrius, Karagas, MR, Margaret A Knowles, Mayordomo JI, Kiemeney LA, Dinney, CP, Gurzau, Eugen, Riboli, E, Riboli, Elio, Dinney CP, Chen M, Grubb R. 3rd, Baris, D., Consol Serra, Borje Ljungberg, Garcia-Closas, M., Hengstler, JG, Polidoro, S., Geraldine Cancel-Tassin, Cussenot, O, Caporaso, N., Pike, MC, Johnson, A, Real, F.X., Teo, MTW, McGrath, M., Sacerdote C, Kogevinas, M., Maria Teresa Landi, Landi, M.T., Canzian, F, Makkinje RR, Tardon, A., Johnson A, Caporaso, Neil, Stern, M.C., Cancel Tassin G, Jan G Hengstler, Caporaso N, Fulvio Ricceri, Vermeulen SH, Clavel-Chapelon, F., Lloreta J, Allen, NE, Koppova, K., Navarro, Carmen, Xu, ZL, Gapstur, SM, Schwenn, Molly, Karagas MR, Robert Grubb, Ljungberg, B, Allen NE, Sanz Velez JI, Serra, Consol, Godfrey, A, Polidoro, Silvia, Hunter, David J, María D García-Prats, Selinski, S., De Vivo, I., Prokunina Olsson L, Fu, YP, Virtamo, J., Schned, Alan, Alessandra Allione, José I Sanz-Velez, J Alfred Witjes, Garcia-Closas, R., Giuseppe Matullo, Teo, MT, Golka K, Adonina Tardón, Sanchez M, Chen, M., Van Den Berg, D, Chatterjee, N, Clavel Chapelon F, Bolick, S.C., Yang, H, Fu, Y., Mariana C Stern, Diver, W.R., Andriole, Gerald, Pike, Malcolm C, Rudnai, P, Yi-Ping Fu, Diver, W Ryan, Hunter, DJ, Grubb R 3rd, Margaret R Karagas, De Vivo, Immaculata, Kvetoslava Koppova, Besenbacher, S., Cortessis, Victoria K, Grubb R, Tjonneland, A., Stern, Mariana C, Carmen Navarro, Burdett, L., Anne Tjonneland, Andriole, G, Jacobs KB, Canzian, Federico, Fu Y, Elio Riboli, Laurie Burdett, Hengstler, Jan G, Serra, C, Karagas, Margaret R, De Vivo, I, Gapstur SM, Tardón García, Adonina, Czerniak B, Black, A, Wu, X, Baris, Dalsu, Guarrera, S, Eric J Jacobs, Teo, Mark T W, D García-Prats M, Eugen Gurzau, Taylor, Jack A, Yuan JM, Gago Dominguez M, Knowles MA, Golka, Klaus, Valdivia, Gabriel, Francoise Clavel-Chapelon, Guarrera, Simonetta, Michael Thun, Black A, García Closas R, Kiltie, Anne E, Fraumeni, JF, Benhamou, S, Lloreta, J, Besenbacher, Soren, Bolick, Sophia C E, McGrath, M, Ashley Godfrey, D García-Prats, María, Bolick, SCE, Kiltie, A.E., Kiltie AE, MA Hildebrandt, Dimitrios Trichopoulos, Cussenot, O., Wu, XF, Cancel-Tassin G, Rothman, Nathaniel, Hildebrandt MA, Rafnar, T, Trichopoulos, D., Brennan P, Virtamo J, Robert N Hoover, Purdue, Mark P, Grubb, R, Polidoro, S, Ricceri, F, Thun, M, Allen, N.E., Chanock, SJ, Allione, A., Yeager, Meredith, Thun, Michael, Porru S, Sanz-Velez, JI, Wu, X., Xu, Zongli, Jack A Taylor, Manuela Gago-Dominguez, Garcia-Closas, Montserrat, Debra T Silverman, Chatterjee, N., Monica McGrath, Koppova, K, Alison Johnson, Meng Chen, Makkinje, Remco R, Purdue, MP, Caporaso, N, Fraumeni JF Jr, Paul Brennan, Patrick Sulem, Chen, M, Brennan, P, Real FX, Trichopoulos, Dimitrios, Virtamo, Jarmo, Jacobs, E.J., Koppova K, Hildebrandt, MAT, De Vivo I, Allione, Alessandra, Purdue, M., Andriole G. Jr, Godfrey A, Brennan, Paul, Tjonneland, A, Schwenn, M, Vineis, P, Montserrat Garcia-Closas, Kiemeney, LA, Silverman, Debra T, Pike, M.C., Rajiv Kumar, Kevin B Jacobs, Schned, A., Sulem, P., Kiemeney, L.A.L.M., Sacerdote, C., Garcia Closas M, Canzian, F., Polidoro S, Zongli Xu, Hengstler, J.G., Jacobs, K.B., Baris D, Jacobs, EJ, Yang, HS, Wang, Z., Sophia C E Bolick, Black, A., Makkinje, R.R., García Closas, Montserrat, Trichopoulos, D, Katja K Aben, Berg, D.P.G. van den, Albanes, D., Jacobs, Eric J, Landi MT, Gurzau E, Kogevinas, M, Sacerdote, Carlotta, Porru, Stefano, Guarrera, S., Wang, Zhaoming, Rudnai P, Ljungberg, Börje,, Panico, Salvatore, Yang, H., Josep Lloreta, Hunter, D.J., Matullo G, Wheeler, W, Virtamo, J, Burdett, Laurie, Figueroa JD, Garcia-Prats, MD, Silverman DT, Tardón A, Jonine D Figueroa, Rafnar T, David J Hunter, Aben, K.K.H., Hoover, RN, Wang, Z, Wang, ZW, W Ryan Diver, Lloreta, Josep, Knowles, Margaret A, Wheeler, W., Prokunina-Olsson, L., D García-Prats, M, Landi, Maria Teresa, Kari Stefansson, Stephen J Chanock, Valdivia, G, Hildebrandt, Michelle AT, Bishop, David T, Joseph F Fraumeni, Figueroa, J.D., Garcia-Closas M, Ricceri, F., Immaculata De Vivo, Remco R Makkinje, Bueno de Mesquita HB, Malats, Nuria, Silvia Polidoro, Sulem, P, Pike MC, Cortessis, VK, Mayordomo, JI, Chanock, Stephen J., Mark P Purdue, Weinstein, Stephanie J, Thun, M., Hutchinson, A., Panico, S., Simone Benhamou, Chanock SJ, Bolick, SC, Bolick SC, Amanda Black, Tardon, A, Andriole G Jr, Dalsu Baris, Brennan, P., Allione, A, Hoover, Robert N, Fraumeni JF, Jian-Min Yuan, Meredith Yeager, Yeager, M., Karagas, M.R., Jose I Mayordomo, Landi, MT, Clavel-Chapelon F, Hunter DJ, Real, Francisco X, Matullo, G, Weinstein SJ, Soren Besenbacher, Hoover RN, Selinski, S, Hutchinson, A, Besenbacher S, Navarro C, Makkinje, RR, Cortessis, V.K., Rothman, N, Porru, S, Ludmila Prokunina-Olsson, Burdett, L, Andriole, G.L., Andriole G, Sacerdote, C, Malats, N., Figueroa, Jonine D, Sulem, Patrick, Prokunina-Olsson L, Anne E Kiltie, Ricceri F, Cussenot, Olivier, Stern, MC, Michelle A T Hildebrandt, Matullo, G., Johnson, A., Nilanjan Chatterjee, Kumar, R, CAPORASO, NICOLA, Tjonneland, Anne, Taylor, J.A., Kiltie, AE, Sita H Vermeulen, Demetrius Albanes, Real, Francisco X., William Wheeler, Gapstur, Susan M, Cortessis VK, Vilneis, P., Dietrich, Holger, Schwenn M, Jarmo Virtamo, Rafnar, Thorunn, Figueroa, JD, Vermeulen, SH, Bueno-de-Mesquita, H Bas, Guarrera S, Jacobs, Kevin B, Dietrich H, Cancel-Tassin, G, Dinney, C.P., Stefansson, Kari, Ricceri, Fulvio, Prokunina-Olsson, Ludmila, Serra, C., Chatterjee, Nilanjan, Grubb, R., Molly Schwenn, Vermeulen, S., Canzian F, García Prats MD, Cussenot O, Carlotta Sacerdote, Bolick, Sophia CE, Zhaoming Wang, Weinstein, S.J., Manuel Sanchez, Schwenn, M., Van Den Berg D, Hildebrandt, Michelle A T, Stern MC, Wheeler W, Clavel-Chapelon, Francoise, Rudnai, Peter, Malats N, Dietrich, H, Grubb, Robert, Bueno-De-Mesquita, H.B., Riboli E, Wu, Xifeng, Cancel-Tassin, G., Kogevinas M, Witjes, JA, Stefano Porru, Garcia-Closas, M, Gago-Dominguez M, Witjes, J Alfred, Purdue MP, Nathaniel Rothman, Simonetta Guarrera, Rafnar, T., Bishop, D.T., Garcia-Closas, R, Diver, WR, Albanes D, Fletcher, Tony, Gabriel Valdivia, Kiemeney, Lambertus A, Stefansson K, Susan M Gapstur, Aben, Katja K, Bishop DT, Yuan, JM, Victoria K Cortessis, Kogevinas, Manolis, Kumar R, Amy Hutchinson, Lambertus A Kiemeney, Bueno-de-Mesquita HB, Benhamou S, Yeager M, Witjes JA, Carrato, Alfredo, Gago-Dominguez, Manuela, Teo, M.T., Neil Caporaso, Wang Z, Ljungberg B, Wu X, Yang H, Gurzau, E, Yuan, Jian-Min, Schned, A, Serra C, Navarro, C, Reina García-Closas, Holger Dietrich, Golka, K., David T Bishop, Burdett L, Salvatore Panico, Aben, KK, Sanchez, M, Witjes, J.A., Yang, Hushan, D. García Prats M, Gapstur, S.M., Czerniak, B, Selinski, Silvia, Schned A, Silvia Selinski, Yuan, J.M., Stephanie J Weinstein, Sanz-Velez, José I, Carrato, A., Malats, N, Fu, Yi-Ping, Den Berg DV, Hutchinson, Amy, García-Closas R, Vivo ID, Knowles, MA, Thorunn Rafnar, Alfredo Carrato, Carrato, A, Johnson, Alison, Bogdan Czerniak, Gerald Andriole, Teo, Mark TW, Aben KK, Carrato A, Jacobs, KB, Mayordomo, J.I., Fletcher, T., Rudnai, P., Fu YP, Kumar, R., Paolo Vineis, Selinski S, Golka, K, David Van Den Berg, Black, Amanda, Jacobs, Eric J., Vermeulen, Sita H., Lloreta Trull, Josep, 1958-, Karagas, Margaret R., Mayordomo, Jose I., Kiltie, Anne E., Cortessis, Victoria K., Bishop, David T., Kiemeney, Lambertus A., Garcia-Closas, Reina, Stern, Mariana C., Hengstler, Jan G., Aben, Katja K., Makkinje, Remco R., Diver, W. Ryan, Witjes, J. Alfred, Silverman, Debra T., Figueroa, Jonine D., Bueno-de-Mesquita, H. Bas, Gapstur, Susan M., Sanz-Velez, Jose I., Bolick, Sophia C. E., Jacobs, Kevin B., Purdue, Mark P., Garcia-Prats, Maria D., Hunter, David J., Teo, Mark T. W., Weinstein, Stephanie J., Andriole, Gerald, Jr., Hildebrandt, Michelle A. T., Van den Berg, David, Allen, Naomi E., Taylor, Jack A., Dinney, Colin P., Fraumeni, Joseph F., Jr., Tardon, Adonina, Hoover, Robert N., Knowles, Margaret A., Grubb, Robert, III, Pike, Malcolm C. +611 morecore +2 more sourcesMucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases
Advanced Science, EarlyView.CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu +13 morewiley +1 more sourceUrinary Bladder Detrusor Dysfunction Symptoms in Lyme Disease [PDF]
International Neurourology Journal, 2013 Symptoms of urinary bladder detrusor dysfunction have been rarely reported in Lyme disease. The aim was to carry out the first systematic study to compare the prevalence of such symptoms in a group of Lyme disease patients and a group of matched controls.A questionnaire relating to detrusor function was administered to 17 serologically positive Lyme ...Puri, BK, Shah, M, Julu, PO, Kingston, MC, Monro, JA +4 moreopenaire +4 more sourcesUrinary ATP as an indicator of infection and inflammation of the urinary tract in patients with lower urinary tract symptoms [PDF]
, 2015 BACKGROUND:
Adenosine-5'-triphosphate (ATP) is a neurotransmitter and inflammatory cytokine implicated in the pathophysiology of lower urinary tract disease. ATP additionally reflects microbial biomass thus has potential as a surrogate marker of urinary Baio, Gianluca, Malone-Lee, James, De Iorio, Maria, Sathiananamoorthy, Sanchutha, Horsley, Harry, Wildman, Scott S.P., Rohn, Jennifer L, Gill, Kiren, Khasriya, Rajvinder, Wildman, Scott, Kupelian, Anthony S +10 morecore +1 more source
