Results 1 to 10 of about 1,313,120 (353)

Treatment of muscle‐invasive and advanced bladder cancer in 2020

Ca-A Cancer Journal for Clinicians, 2020
Bladder cancer accounts for nearly 170,000 deaths worldwide annually. For over 4 decades, the systemic management of muscle‐invasive and advanced bladder cancer has primarily consisted of platinum‐based chemotherapy.
Vaibhav G Patel, Matthew D Galsky, William K Oh   +2 more
exaly   +2 more sources

Advances in bladder cancer biology and therapy

Nature Reviews Cancer, 2020
Linda L Tran, Jin-Fen Xiao, Neeraj Agarwal   +2 more
exaly   +2 more sources

Combined exome and transcriptome sequencing of non-muscle-invasive bladder cancer: associations between genomic changes, expression subtypes, and clinical outcomes

Genome Medicine, 2022
Background Three-quarters of bladder cancer patients present with early-stage disease (non-muscle-invasive bladder cancer, NMIBC, UICC TNM stages Ta, T1 and Tis); however, most next-generation sequencing studies to date have concentrated on later-stage ...
Anshita Goel, Douglas G. Ward, Boris Noyvert, Minghao Yu, Naheema S. Gordon, Ben Abbotts, John K. Colbourne, Stephen Kissane, Nicholas D. James, Maurice P. Zeegers, Kar Keung Cheng, Jean-Baptiste Cazier, Celina M. Whalley, Andrew D. Beggs, Claire Palles, Roland Arnold, Richard T. Bryan   +16 more
doaj   +1 more source

Novel intravesical therapeutics in the treatment of non-muscle invasive bladder cancer: Horizon scanning

Frontiers in Surgery, 2022
IntroductionNon-muscle-invasive bladder cancer (NMIBC) is a common and heterogeneous disease; many patients develop recurrent or progress to muscle-invasive disease.
Kelly Ward, Mark O Kitchen, Suresh-Jay Mathias, Farhat L Khanim, Richard T. Bryan   +4 more
doaj   +1 more source

An unusual case of vaginal mass – subpubic cartilaginous cyst

Urology Case Reports, 2021
Subpubic cartilaginous cyst is a rare form of ganglion cyst that arises on the inferior surface of the pubis symphysis. The pathophysiology is poorly understood but has been hypothesised to be secondary to mucinous degeneration of the pubic supporting ...
Elliot Anderson, Henry Han-I Yao, Richard Baverstock, Kevin Carlson   +3 more
doaj   +1 more source

PD-L2 Is Constitutively Expressed in Normal and Malignant Urothelium

Frontiers in Oncology, 2021
The use of immune checkpoint blockade, in particular PD-1 and PD-L1 inhibitors, is now commonplace in many clinical settings including the treatment of muscle-invasive bladder cancer (MIBC).
Alexander C. Dowell, Haydn Munford, Anshita Goel, Naheema S. Gordon, Nicholas D. James, K. K. Cheng, Maurice P. Zeegers, Maurice P. Zeegers, Douglas G. Ward, Richard T. Bryan   +9 more
doaj   +1 more source

Current best practice for bladder cancer: a narrative review of diagnostics and treatments.

The Lancet, 2022
This Seminar presents the current best practice for the diagnosis and management of bladder cancer. The scope of this Seminar ranges from current challenges in pathology, such as the evolving histological and molecular classification of disease, to ...
E. Compérat, M. Amin, R. Cathomas, A. Choudhury, M. De Santis, A. Kamat, A. Stenzl, H. Thoeny, J. Witjes   +8 more
semanticscholar   +1 more source

STAG2 Protein Expression in Non–muscle-invasive Bladder Cancer: Associations with Sex, Genomic and Transcriptomic Changes, and Clinical Outcomes

European Urology Open Science, 2022
Background: Mutations in STAG2 cause complete loss of STAG2 protein in approximately one-third of non–muscle-invasive bladder cancers (NMIBCs). STAG2 protein expression is easily determined via immunohistochemistry (IHC) and published data suggest that ...
Naheema S. Gordon, Nada Humayun-Zakaria, Anshita Goel, Ben Abbotts, Maurice P. Zeegers, K.K. Cheng, Nicholas D. James, Roland Arnold, Richard T. Bryan, Douglas G. Ward   +9 more
doaj   +1 more source

Normalization of Real-Time Quantitative Reverse Transcription-PCR Data: A Model-Based Variance Estimation Approach to Identify Genes Suited for Normalization, Applied to Bladder and Colon Cancer Data Sets

Cancer Research, 2004
Accurate normalization is an absolute prerequisite for correct measurement of gene expression. For quantitative real-time reverse transcription-PCR (RT-PCR), the most commonly used normalization strategy involves standardization to a single ...
C. Andersen, J. L. Jensen, T. Ørntoft
semanticscholar   +1 more source

Bladder Cancer: Current Challenges and Future Directions

Medicina, 2021
Bladder cancer (BCa) is the most common malignancy of the urinary tract and one of the most prevalent cancers worldwide. While the clinical approach to BCa has remained largely unchanged for many years, recent discoveries have paved the way to a new era ...
J. Dobruch, M. Oszczudłowski
semanticscholar   +1 more source