Results 141 to 150 of about 114,734 (260)

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, EarlyView.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

Urinary bladder invasion secondary to dissemination of gallbladder cancer: an unusual presentation. [PDF]

Clin J Gastroenterol
Watanabe R, Koshitani T, Hashidume S, Kasho K, Yokomura A, Takihara H, Takemoto T, Itoh M, Nakajima N.   +8 more
europepmc   +1 more source

UBE2C‐Mediated CD147‐CTLA‐4 Axis Promotes T Cell Exhaustion and Immunosuppressive Microenvironment in Bladder Cancer

Cancer Science, EarlyView.
UBE2C upregulates cellular CD147 and enhances its release into the tumor microenvironment both as soluble CD147 (sCD147) and packaged within tumor‐derived exosomes. These CD147‐bearing signals induce T‐cell exhaustion, marked by elevated CTLA‐4 expression and reduced secretion of effector cytokines (IFN‐γ, TNF‐α, TGF‐β), ultimately diminishing CD8+ T ...
Xuwei Hong, Ting Hong, Xinyu Liu, Peixiu Yao, Weiqiang Lin, Guoyuan Liu, Huihong Guan, Yonghai Zhang   +7 more
wiley   +1 more source

Urinary DNA methylation biomarkers for bladder cancer diagnosis: a single center case-control study. [PDF]

Front Oncol
Li C, Fang R, Wang J, Wang Y, Zhao S, Wu Q, Ying C, Rao M.   +7 more
europepmc   +1 more source

SUBDUE‐3: SUB‐urothelial DUrvalumab‐89zirconium injEction; a phase 0 biodistribution study protocol

BJU International, EarlyView.
Kevin G. Keane, Richard Gauci, Roslyn J. Francis, Andrew M. Scott, Cynthia Hawks, Andrisha‐Jade Inderjeeth, Ian D. Davis, Jayne Lim, Andrew Redfern, Dickon Hayne   +9 more
wiley   +1 more source

When Small Cells Matter: Diagnosing Bladder Small Cell Carcinoma on Urine Cytology

Cytopathology, EarlyView.
Small cell carcinoma of the bladder is rare, aggressive and diagnostically challenging on urine cytology. We report a case detected in urine and confirmed by cell block immunohistochemistry, highlighting the importance of careful assessment and limitations of the Paris System.
Haley Corbin, Samer Khader, Gabriela Quiroga‐Garza, Liron Pantanowitz   +3 more
wiley   +1 more source

Bladder stromal tumor of uncertain malignant potential arising in ectopic prostatic tissue: Case report with MRI-pathology correlation. [PDF]

Radiol Case Rep
Schoijet IAM, Faúndes GS, Weitzler AL, Rojas KR, Ebner JC.   +4 more
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Urinary microbiota diversity and composition in patients with advanced renal cell cancer. [PDF]

BJUI Compass
Leal F, Filho RM, Inoue LT, Heidrich V, Dos Santos EX, Bastos DA, Camargo AA, Jardim DLF.   +7 more
europepmc   +1 more source

Use of MRI in the diagnosis of bladder cancer: a health economic analysis

BJU International, EarlyView.
Niranjan Sathianathen, Marlon Perera, Joseph Ischia, Nathan Lawrentschuk, Damien Bolton   +4 more
wiley   +1 more source