Results 131 to 140 of about 319,061 (288)

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

open access: yesAdvanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao   +6 more
wiley   +1 more source

Urinary bowel stone: calculus formation in a repurposed small intestine - a case report

open access: yesBMC Nephrology
Background Urinary diversion with an ileal conduit is associated with an increased risk of urinary tract calculi, driven by metabolic disturbances, recurrent infections, urinary stasis, and foreign bodies. Although stone formation is a known complication,
Diana Santos   +3 more
doaj   +1 more source

STUDIES OF URINARY STONES FOURTH REPORT: INFRARED SPECTROPHOTOMETRIC ANALYSIS OF URINARY CALCULI AND CLINICAL MANIFESTATIONS [PDF]

open access: yes, 1978
187 urinary stones were analyzed by infrared spectroscopy. 1) The composition of 187 calculi was as follows. Calcium oxalate combined with calcium phosphate composed 47.1 % of 187 stones, calcium oxalate alone 27.1 %, combination of calcium phosphate and
井上, 武夫   +3 more
core  

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

open access: yesAdvanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin   +12 more
wiley   +1 more source

Protease‐Triggered Chromogenic Release From Peptide‐Modified Calcium Carbonate Microspheres Enables Colorimetric Detection of Porphyromonas gingivalis Activity

open access: yesAdvanced Science, EarlyView.
We report a chromogenic release‐based assay system with protease‐cleavage peptide‐modified calcium carbonate microspheres for colorimetric detection of Porphyromonas (P.) gingivalis activity. In response to Arg‐specific gingipain secreted by P. gingivalis, the supernatant becomes colored, enabling colorimetric analysis and providing the monitoring of ...
Yuki Hiruta   +9 more
wiley   +1 more source

Urinary calculi: bacteriological and chemical association

open access: yes, 2001
763-770We investigated the bacteriology of urinary calculi in relation to urinary tract infection, stone formation, chemical composition and antibiotic sensitivity. Fifty-two patients [37 males, 15 females] with urolithiasis were studied.
Naas, T., Bashir, O., Al Agili, S.
core  

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

open access: yesAdvanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li   +10 more
wiley   +1 more source

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