Results 61 to 70 of about 631,184 (278)

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Methuosis Inducer SGI‐1027 Cooperates with Everolimus to Promote Apoptosis and Pyroptosis by Triggering Lysosomal Membrane Permeability in Renal Cancer

Advanced Science
The mTOR inhibitor everolimus has been approved as a sequential or second‐line therapy for renal cell carcinoma (RCC). However, the development of drug resistance limits its clinical applications.
Yu Luo, Bing Guan, Xiaoqi Deng, Peide Bai, Haichao Huang, Chaohao Miao, Anran Sun, Zhipeng Li, Dianqiang Yang, Xuegang Wang, Zhiqiang Shao, Yulong Wu, Jinchun Xing, Bin Chen, Tao Wang   +14 more
doaj   +1 more source

Risk factors for systemic inflammatory response syndrome after endoscopic lithotripsy for upper urinary calculi

BMC Urology, 2023
Background To explore the risk factors for systemic inflammatory response syndrome (SIRS) after endoscopic lithotripsy for upper urinary calculi. Methods This retrospective study included patients with upper urinary calculi who underwent endoscopic ...
Siming Ye, Wei Wang, Zhenliang Yu, Jie Luo   +3 more
doaj   +1 more source

A review of artificial intelligence in brachytherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Artificial intelligence (AI) has the potential to revolutionize brachytherapy's clinical workflow. This review comprehensively examines the application of AI, focusing on machine learning and deep learning, in various aspects of brachytherapy.
Jingchu Chen, Richard L. J. Qiu, Tonghe Wang, Shadab Momin, Xiaofeng Yang   +4 more
wiley   +1 more source

Epidemiology of urolithiasis with emphasis on ultrasound detection: A retrospective analysis of 5371 cases in Saudi Arabia

Saudi Journal of Kidney Diseases and Transplantation, 2015
This retrospective study was conducted to determine the prevalence of urinary calculi in the indigenous population of Saudi Arabia and compare it with expatriates of different nationalities working in Saudi Arabia with emphasis on the anatomic location ...
Farid Ahmad, Medhat O Nada, Afsan Bin Farid, M A Haleem, S. M. A. Razack   +4 more
doaj   +1 more source

Ceftazidime-related urinary calculi in a young boy: a case report

Journal of International Medical Research, 2020
Certain drugs can cause kidney stones but as far as we are aware, ceftazidime-related urinary calculi have not been previously reported. We report here a case of an 8-year-old boy who developed hydronephrosis secondary to urinary calculi after receiving ...
Pan Gao, Zonglai Liu, Han Yang, Ziqiu He, Zhi Zhang, Xiong Guo, Hongbo Zhang, Wei Ai, Dan Du   +8 more
doaj   +1 more source

Validity and Reliability of Clinical and Patient‐Reported Outcomes in Multisystem Proteinopathy 1

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Valosin‐containing protein (VCP)‐associated multisystem proteinopathy 1 (MSP1) is caused by variants in the VCP gene. MSP1 results in various phenotypes including progressive myopathy, Paget's disease of bone, frontotemporal dementia, amyotrophic lateral sclerosis, and parkinsonism, among others.
Lindsay N. Alfano, Megan A. Iammarino, Natalie F. Reash, Linda P. Lowes, Lindsay Pietruszewski, Kathleen Adderley, Lauren Humphrey, Audrey B. Knight, Christopher L. Steiner, Melissa A. Smith, Zarife Sahenk, Anne M. Connolly, Momen Almomen, Eleonora S. D'Ambrosio, Nathan Peck, Allison Peck   +15 more
wiley   +1 more source

Association between folate and glutamine metabolism and prognosis of kidney cancer

Frontiers in Nutrition
BackgroundRecent studies have shown that folate metabolism might influence cancer progression by regulating mitochondrial metabolism and glutamine is involved in the development and progression of several malignancies.
Jiaxuan Qin, Jiaxuan Qin, Jiaxuan Qin, Jiaxuan Qin, Chaoyue Ouyang, Chaoyue Ouyang, Chaoyue Ouyang, Chaoyue Ouyang, Xuan Zhuang, Xuan Zhuang, Xuan Zhuang, Xuan Zhuang   +11 more
doaj   +1 more source

Twist Sequent Calculi for S4 and its Neighbors [PDF]

EPTCS 415, 2024, pp. 16-32
Two Gentzen-style twist sequent calculi for the normal modal logic S4 are introduced and investigated. The proposed calculi, which do not employ the standard logical inference rules for the negation connective, are characterized by several twist logical inference rules for negated logical connectives.
arxiv   +1 more source

The Undecidability of Pattern Matching in Calculi where Primitive Recursive Functions are Representable [PDF]

arXiv, 2023
We prove that the pattern matching problem is undecidable in polymorphic lambda-calculi (as Girard's system F) and calculi supporting inductive types (as G{\"o}del's system T) by reducing Hilbert's tenth problem to it. More generally pattern matching is undecidable in all the calculi in which primitive recursive functions can be fairly represented in a
arxiv