Results 181 to 190 of about 175,640 (264)

Pharmacokinetics and pharmacodynamics of empagliflozin in paediatric patients aged 10–17 years with type 2 diabetes mellitus

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims To characterize the pharmacokinetics (PK) and PK/pharmacodynamics (PD) regarding glycosylated haemoglobin (HbA1c) lowering using the paediatric data from DINAMO and to assess differences compared with adults. Methods Population PK and PK/PD models previously developed for empagliflozin in adults and adolescents were re‐estimated in a Bayesian ...
Juliane Rascher   +7 more
wiley   +1 more source

Investigating Postoperative Urinary Retention: Risk Factors and Postsurgical Outcomes in Total Joint Arthroplasty. [PDF]

open access: yesArthroplast Today
Powers MJF   +5 more
europepmc   +1 more source

The contribution of extracellular RNA and its derived biomaterials in disease management

open access: yesBMEMat, EarlyView.
The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei   +8 more
wiley   +1 more source

High‐throughput exosomes analysis for ovarian cancer screening based on a double‐positive surface marker detection biochip

open access: yesBMEMat, EarlyView.
A double‐positive surface marker detection approach was developed to conduct exosome surface protein detection in serum samples. It reaches single‐exosome detection, and over 300 exosome protein parameters are analyzed. The diagnostic accuracy achieved 90% in differentiation of high‐grade serous/serous ovarian carcinoma patients, benign patients, and ...
Jiaoyan Qiu   +7 more
wiley   +1 more source

Renal Arterial Anatomy: Implications for Normothermic Machine Perfusion in Renal Transplantation

open access: yesClinical Anatomy, EarlyView.
ABSTRACT Normothermic machine perfusion (NMP) is a novel technology that has shown potential in viability assessment and reconditioning of donor organs. Normothermic machine perfusion is technically more challenging in kidneys with multiple renal arteries (RAs).
Lily Mae Miller   +3 more
wiley   +1 more source

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

open access: yesCancer Communications, EarlyView.
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao   +12 more
wiley   +1 more source

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