Results 101 to 110 of about 544,439 (228)

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Current applications of nanomaterials in urinary system tumors. [PDF]

Front Bioeng Biotechnol, 2023
Qian Z, Zhang Y, Yuan J, Gong S, Chen B.
europepmc   +1 more source

PDZK1‐ULK1 Axis Triggers Lipophagy to Inhibit Tumor Progression and Sunitinib Resistance in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reveals that PDZK1 loss impairs ULK1‐mediated lipophagy, driving lipid droplet accumulation and sunitinib resistance in clear cell renal cell carcinoma. PDZK1 inhibits LEF1 nuclear translocation, enhancing ULK1 transcription. Pharmacological ULK1 activation resensitizes resistant tumors to sunitinib.
Xuan Qi, Yu Guo, Yumeng Yang, Haibo Wang, Xiaomei Yang, Ran Song, Qiong Qin, Yan Zhang, Meihan Hu, Haixing Zhou, Duiping Feng, Junqi He   +11 more
wiley   +1 more source

The Role of DNA Methyltransferases in Urinary System Diseases. [PDF]

Cancer Innov
Dong W, Pei S, Zhu D, Zeng C, Qiu Y, Wu Y, Jia X, Zhang S, Li C, Zhang W, Zhang W, Chen Z.   +11 more
europepmc   +1 more source

Their last will and testament: dying immune cells protect the urinary system with extracellular DNA traps. [PDF]

Kidney Int, 2023
Steers NJ, Barasch J.
europepmc   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Primary urachal actinomycosis: A literature review

Asian Journal of Surgery, 2020
Jiaxuan Qin, Yuedong Chen, Jinchun Xing, Zonglong Cai   +3 more
doaj   +1 more source

Ectopic adrenocortical nodular hyperplasia mimicking an upper-pole renal-cell carcinoma: A case report

Asian Journal of Surgery, 2023
Dawei Lin, Jiaxuan Qin, Jinchun Xing
doaj   +1 more source

Causal association between socioeconomic disparities and tumors of the urinary system: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Chen WW, Wu B, Wen X.
europepmc   +1 more source

Actomyosin Activity and Piezo1 Activity Synergistically Drive Urinary System Fibroblast Activation. [PDF]

Adv Sci (Weinh), 2023
Chen G, Gao X, Chen J, Peng L, Chen S, Tang C, Dai Y, Wei Q, Luo D.   +8 more
europepmc   +1 more source