Results 91 to 100 of about 752,211 (305)

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Hubungan Antara Kualitas Perawatan Kateter Dengan Kejadian Infeksi Nosokomial Saluran Kemih [PDF]

, 2007
Nosocomial infection refer to occurrence the often happen in hospital and can causes import to patient, family and hospital of self. Once of infection that often happened is infection of urinary tract at the patient with dower chateter.
Hidayati, W. (Wahyu), Kasmad, K. (Kasmad), Sujianto, U. (Untung)   +2 more
core   +1 more source

Affinity‐Based Protein Profiling Revealed that HIGD1A is a Direct Target Protein of Aristolochic Acids

Advanced Science, EarlyView.
Using an affinity‐based probe, this study reveals that aristolochic acid directly binds to HIGD1A with high affinity in the kidney. This binding disrupts the HIGD1A‐TFAM interaction, which in turn triggers TFAM degradation, cytosolic mitochondrial DNA release, and the activation of inflammatory pathways. Abstract Exposure to aristolochic acids (AA) via
Yin Gong, Shanshan Zhang, Anying Wei, Xiang Ji, Xiaodan Chong, Jinfeng Cen, Xuan Zhao, Zimeng Luo, Zhipeng Pei, Guanchao Mao, Xinkang Zhang, Mingxue Sun, Zhiguo Sun, Zifei Yin, Zhengrong Zou, Wen‐Qi Meng   +15 more
wiley   +1 more source

Principles for Rigorous Design and Application of Synthetic Microbial Communities

Advanced Science, EarlyView.
SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang, Minyu Jing, Lihui Lyu, Li Nie, Xihui Xu, Ru Sun, Xiyuan Xu, Siyu Chen, Shuobing He, Yumeng Zhang, Ping Huang, Weijie Luo, Jiaojiao Liang, Guifeng Gao, Kunkun Fan, Teng Yang, Liyan Zhang, Xiao Fu, Sarah M. Allard, Jack A. Gilbert, Jiabao Zhang, Haiyan Chu   +21 more
wiley   +1 more source

Association between folate and glutamine metabolism and prognosis of kidney cancer

Frontiers in Nutrition
BackgroundRecent studies have shown that folate metabolism might influence cancer progression by regulating mitochondrial metabolism and glutamine is involved in the development and progression of several malignancies.
Jiaxuan Qin, Jiaxuan Qin, Jiaxuan Qin, Jiaxuan Qin, Chaoyue Ouyang, Chaoyue Ouyang, Chaoyue Ouyang, Chaoyue Ouyang, Xuan Zhuang, Xuan Zhuang, Xuan Zhuang, Xuan Zhuang   +11 more
doaj   +1 more source

Research and progress on the mechanism of lower urinary tract neuromodulation: a literature review [PDF]

PeerJ
The storage and periodic voiding of urine in the lower urinary tract are regulated by a complex neural control system that includes the brain, spinal cord, and peripheral autonomic ganglia.
Shutong Pang, Junan Yan
doaj   +2 more sources

Under‐Urine‐Adhered Supramolecular Hydrogel with Linearly Sustained Quercetin Release Facilitates Hemorrhagic Cystitis Healing via Inflammation Regulation

Advanced Science, EarlyView.
A supramolecular gelatin‐based hydrogel adhesive was engineered for hemorrhagic cystitis management. It provides robust wet‐tissue adhesion, rapid hemostasis, sustained quercetin release, effectively restoring the bladder barrier via anti‐inflammatory and antioxidant actions.
Xu Cao, Hua Zhang, Yang Luo, Yaoqi Chen, Jie Yao, Renhao Ni, Tong Zhu, Yudong Yao, Jun Chen, Baolin Guo, Kerong Wu   +10 more
wiley   +1 more source

CLINICAL STUDY OF URINARY TRACT INFECTION - 12. CLINICAL STATISTICS IN CHILDREN AND DIAGNOSTIC SIGNIFICANCE OF URINARY SEDIMENT [PDF]

, 1973
During six and a half years period, Jan. 1966 to June 1972, 248 children with urinary tract infection were seen at the Department of Urology, Hiroshima University Hospital. The clinical statistics were made on their symptoms, age, sex etc.
仁平, 寛巳, 小田, サキ子, 広本, 宣彦, 清水, 凡生, 石部, 知行, 碓井, 亜, 臼井, 朋包, 藤井, 肇   +7 more
core  

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

What paediatricians need to know about modern urologic management of vesicoureteral reflux

Frontiers in Pediatrics
Vesicoureteral reflux (VUR) is a common urological disorder in children, and its prevalence is difficult to determine, as many VUR cases remain asymptomatic.
Jeanne Goulin, Jeanne Goulin, Jeanne Goulin, Delphine Demède, Delphine Demède, Bruno Ranchin, Mélodie Mosca, Aurélie De-Mul, Valeska Bidault Jourdainne, Valeska Bidault Jourdainne, Valeska Bidault Jourdainne, Valeska Bidault Jourdainne   +11 more
doaj   +1 more source