Results 91 to 100 of about 1,115,196 (302)

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Zinner’s syndrome in two young middle-aged men: a case report and review of the literature

BMC Urology
Zinner syndrome (ZS) is a relatively uncommon congenital genitourinary malformation, characterised by a triad of conditions: unilateral renal hypoplasia or dysplasia, ipsilateral ejaculatory duct obstruction and seminal vesicle cysts. This association is
Yifan Huang, Bingzhi Han, Zikai Huang, Qianhao Huang, Tao Wang, Yuedong Chen   +5 more
doaj   +1 more source

Lower urinary tract symptoms and urinary incontinence during pregnancy

, 2016
Objective: Lower urinary tract symptoms (LUTS) can frequently be seen in pregnant women. Pregnancy and delivery have been considered as risk factors in the occurrence of pelvic floor dysfunction and determinants of LUTS.
Güven, Emine Seda Güvendağ, Tekin, Yeşim Bayoğlu, Üstüner, Işık, Ural, Ülkü Mete, Şentürk, Şenol, Kağıtçı, Mehmet, Şahin, Figen Kır, Balık, Gülşah   +7 more
core   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

The Difference of Nosocomial Urinary Tract Infection Risk Based on Chateterization Urine, Age, and Diabetes Mellitus

Jurnal Berkala Epidemiologi, 2015
Nosocomial urinary tract infection is common occurs in patients with indwelling urinary chateter. Factors that caused nosocomial urinary tract infection are host, agent, and chateterization urine.
Edel Weisela Permata Sari, Prijono Satyabakti   +1 more
doaj   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

Urinary antimicrobial peptides and cytokines as biomarkers for recurrent urinary tract infection in children and adolescents

Frontiers in Immunology
BackgroundRecurrent urinary tract infection (rUTI) is a major diagnostic and clinical challenge. Dysregulated innate immune responses, including antimicrobial peptides and cytokines, may underlie UTI susceptibility.
Guillermo Yepes, Hancong Chloe Tang, Natalie Holdsworth, Natalie Holdsworth, Kristin Salamon, Laura Schwartz, Laura Schwartz, Laura Schwartz, Christina Ching, Christina Ching, Christina Ching, Steve Rust, John David Spencer, John David Spencer, John David Spencer   +14 more
doaj   +1 more source

Prevalence of Urinary Incontinence During Pregnancy and Associated Risk Factors [PDF]

, 2017
ObjectiveTo investigate the prevalence of urinary incontinence during pregnancy and associated risk factors. MethodsThe study is a cross-sectional and descriptive study. A questionnaire was conducted with a total of 750 pregnant women about their urinary
Dinc, Ayten, Ayten DİNÇ
core   +1 more source

Comparison of Minimally Invasive Colectomy Between Intra‐ Versus Extra‐Corporeal Anastomosis Technique (COMMIT Study): Short‐Term Analysis

Annals of Gastroenterological Surgery, EarlyView.
This multicenter propensity score‐matched study of 3213 patients compared intracorporeal (IA) and extracorporeal (EA) anastomosis during minimally invasive colectomy. IA was associated with a significantly lower incidence of intraoperative blood loss ≥ 200 mL (2.5% vs.
Takuya Takami, Takehito Yamamoto, Yoshiro Itatani, Ryosuke Mizuno, Kae Okoshi, Yasunori Deguchi, Keiji Nagata, Tomoaki Okada, Rei Mizuno, Kazutaka Obama   +9 more
wiley   +1 more source