Results 91 to 100 of about 410,735 (351)

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

HOSPITAL-ACQUIRED URINARY TRACT INFECTIONS IN CANCER PATIENTS

Сибирский онкологический журнал, 2017
Introduction. Urinary tract infections are among the most frequently seen bacterial infections. Worldwide, about 150 million people are diagnosed with urinary tract infections each year, costing the global economy in excess of 3.5 billion US dollars ...
N. V. Dmitrieva, I. N. Petukhova, Z. V. Grigorievskaya, N. S. Bagirova, I. V. Tereshchenko, V. V. Aginova, I. A. Klyuchnikova, S. A. Dyakova, A. I. Dmitrieva, T. A. Kalinchuk   +9 more
doaj   +1 more source

Antibiotic prophylaxis during extracorporeal shock wave lithotripsy in the prevention of urinary tract infections in patients with sterile urine before the procedure [PDF]

, 2011
Introduction: There are controversies in the literature regarding the need and the duration of antibiotic prophylaxis in patients with extracorporeal shock wave lithotripsy (ESWL), who had a negative urine culture before the operation.
Balmehd, M., Ghazimoghaddam, B., Gholipoor, M., Tajari, H.   +3 more
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Antibiotic prophylaxis is associated with subsequent resistant infections in children with an initial extended-spectrum-cephalosporin-resistant Enterobacteriaceae infection [PDF]

, 2017
The objective of this study was to assess the association between previous antibiotic use, particularly long-term prophylaxis, and the occurrence of subsequent resistant infections in children with index infections due to extended-spectrum-cephalosporin ...
Adler, Amanda L, Burnham, Carey-Ann D, Das, Sibani, Elward, Alexis, Kronman, Matthew P, Miles-Jay, Arianna, Newland, Jason G, Qin, Xuan, Selvarangan, Rangaraj, Sullivan, Kaede V, Weissman, Scott J, Zaoutis, Theoklis, Zerr, Danielle M   +12 more
core   +2 more sources

Affinity‐Based Protein Profiling Revealed that HIGD1A is a Direct Target Protein of Aristolochic Acids

Advanced Science, EarlyView.
Using an affinity‐based probe, this study reveals that aristolochic acid directly binds to HIGD1A with high affinity in the kidney. This binding disrupts the HIGD1A‐TFAM interaction, which in turn triggers TFAM degradation, cytosolic mitochondrial DNA release, and the activation of inflammatory pathways. Abstract Exposure to aristolochic acids (AA) via
Yin Gong, Shanshan Zhang, Anying Wei, Xiang Ji, Xiaodan Chong, Jinfeng Cen, Xuan Zhao, Zimeng Luo, Zhipeng Pei, Guanchao Mao, Xinkang Zhang, Mingxue Sun, Zhiguo Sun, Zifei Yin, Zhengrong Zou, Wen‐Qi Meng   +15 more
wiley   +1 more source

Immunoprophylaxis of recurrent urinary tract infections

Počki, 2019
Recurrent urinary tract infections are an important issue in modern medicine. There are 2 main groups among recurrent infections: the first, occurring against the background of abnormal development of the urinary organs, and the second, recurring for no ...
D.D. Ivanov
doaj   +1 more source

Variability in Catheter-Associated Asymptomatic Bacteriuria Rates Among Individual Nurses in Intensive Care Units: An Observational Cross-Sectional Study [PDF]

, 2019
Catheter-associated asymptomatic bacteriuria (CAABU) is frequent in intensive care units (ICUs) and contributes to the routine use of antibiotics and to antibiotic-resistant infections.
Bobay, Kathleen L., Costa, Deena K., Parada, Jorge P., Weiss, Marianne E., Yakusheva, Olga   +4 more
core   +3 more sources

Under‐Urine‐Adhered Supramolecular Hydrogel with Linearly Sustained Quercetin Release Facilitates Hemorrhagic Cystitis Healing via Inflammation Regulation

Advanced Science, EarlyView.
A supramolecular gelatin‐based hydrogel adhesive was engineered for hemorrhagic cystitis management. It provides robust wet‐tissue adhesion, rapid hemostasis, sustained quercetin release, effectively restoring the bladder barrier via anti‐inflammatory and antioxidant actions.
Xu Cao, Hua Zhang, Yang Luo, Yaoqi Chen, Jie Yao, Renhao Ni, Tong Zhu, Yudong Yao, Jun Chen, Baolin Guo, Kerong Wu   +10 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Bacterial Biofilm and its Clinical Implications [PDF]

, 2018
Microbial biofilm created huge burden in treatment of both community and hospital infections. A biofilm is complex communities of bacteria attached to a surface or interface enclosed in an exopolysaccharide matrix and protected from unfavorable ...
Shakibaie, Prof
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