Results 171 to 180 of about 75,802 (261)

Pharmacokinetics, mass balance, and metabolism of the novel potassium-competitive acid blocker JP-1366 in healthy Chinese adults following a single oral dose of [¹⁴C]JP-1366. [PDF]

Front Pharmacol
Liu X, Deng D, Meng J, Hu H, Zhuang Q, Zhou X, Fu L, Fan B, Xu X, Huang Q, Chen X, Hou F.   +11 more
europepmc   +1 more source

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, EarlyView.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source

Consensus on managing delayed methotrexate elimination in high-dose therapy: insights from the Middle East. [PDF]

Front Oncol
Al Manasour M, Absi A, Alhuraiji A, Khanani MF, Mheidly K, Elsaid M, Ballourah W, Al-Khabori M, Al Zain N, Khalifa N, Rihani R, Abdallah S, Wali Y.   +12 more
europepmc   +1 more source

Learning with Patient Campaigners About a German Drug Scandal

Berichte zur Wissenschaftsgeschichte, EarlyView.
The West German drug Duogynon was internationally marketed as a “hormone pregnancy test” (HPT) between the 1950s and 1980s. In the late 1960s it came under suspicion for inducing miscarriage, spina bifida, and a spectrum of birth defects similar to those caused by the sedative thalidomide.
Jesse Olszynko‐Gryn, Anja Suter, Edmund Bolger, Birgit Nemec   +3 more
wiley   +1 more source

Prediction of silica nanoparticle biodistribution using a calibrated physiologically based model: Unbound fraction and elimination rate constants for the kidneys and phagocytosis identified as major determinants. [PDF]

Int J Clin Pharmacol Ther
Parrot M, Cave J, Pelaez MJ, Ghandehari H, Dogra P, Yellepeddi V.   +5 more
europepmc   +1 more source

Layered double hydroxides‐based nanozymes for effective biomedical applications: A review and future perspectives

BMEMat, EarlyView.
In this review, we introduced the preparation methods of LDHzymes and discussed their catalytic activity and mechanisms. Subsequently, the applications of LDHzymes in biomedical were discussed. Finally, potential future work on LDHzymes was proposed to better design these new types of nanozymes.
Jiawei Cui, Lu Zhang, Junyi Li, Yue Chen, Sheng Dai, Manfred F. Maitz, Ansha Zhao, Ping Yang   +7 more
wiley   +1 more source

Influence of the exposed anatomic sites on the human in vivo percutaneous absorption of the amphiphilic 2-phenoxyethanol. [PDF]

Arch Toxicol
Hiller J, Eckert E, Jäger T, Bader M, Kaifie A, Göen T.   +5 more
europepmc   +1 more source

Fiber‐type soft bioelectronics for wearable and implantable sensing and therapy

BMEMat, EarlyView.
Fiber‐type soft bioelectronics are emerging as versatile platforms for wearable and implantable health monitoring and therapeutic applications. These bioelectronics use organic and inorganic matrices combined with advanced fillers, which feature high conductivity, electrochemical sensitivity, softness, and biocompatibility.
Haneul Kim, Hak Yong Kim, Ja Hoon Koo, Gi Doo Cha, Dae‐Hyeong Kim, Hye Jin Kim   +5 more
wiley   +1 more source

Ultrasensitive Tracking of Dual Antiparasitics in Living Tissues: UPLC-MS/MS Reveals Synergistic Distribution of Oxyclozanide and Levamisole Hydrochloride. [PDF]

Anal Chem
Dai G, Zhou Y, Xu J, Sun K, Li H, Wang Q, Li B, Zhou X, Zhang J.   +8 more
europepmc   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source