Results 181 to 190 of about 75,397 (323)

Frail is not fail: Limited impact of comorbidities on non‐relapse mortality and safety in patients with LBCL treated with CAR‐T

British Journal of Haematology, EarlyView.
We applied three major comorbidity scoring systems—CIRS, HCT‐CI, and Severe4—to a cohort of 379 patients with LBCL treated with CAR‐T therapy. A high comorbidity burden was identified in 7% to 34% of patients, depending on the score used. However, a high comorbidity burden did not negatively impact the tolerability of CAR‐T treatment, including the ...
Eugenio Galli, Roberta Di Blasi, Ilaria Pansini, Caterina Cristinelli, Come Bommier, Ilenia De Bernardis, Alessandro Corrente, Marcello Viscovo, Luca Montini, Patrizia Chiusolo, Stefan Hohaus, Federica Sorà, Catherine Thieblemont, Simona Sica   +13 more
wiley   +1 more source

Is pelvic floor loading in female runners associated with post‐run changes in pelvic floor morphometry or function?

BJU International, EarlyView.
Objectives To investigate whether, among female runners, transient changes in pelvic floor morphometry, pelvic floor muscle (PFM) function, or pad weight gain observed after a standardised running protocol are associated with the exposure of the pelvic floor to loading during the run.
Marie‐Eve Berube, Stefan Niederauer, Ryan Graham, Robert Hitchcock, Linda McLean   +4 more
wiley   +1 more source

Guideline of guidelines: PSMA PET in staging newly diagnosed intermediate‐risk prostate cancer

BJU International, EarlyView.
Objective To provide a comprehensive review and analysis of guidelines from various professional and medical organisations regarding the use of prostate‐specific membrane antigen (PSMA) positron emission tomography (PET) as a staging scan for men with newly diagnosed intermediate‐risk prostate cancer (PCa).
Jonathon Carll, Weiwei Shi, Marlon Perera, Nathan Lawrentschuk, Thilakavathi Chengodu, Dixon Woon   +5 more
wiley   +1 more source

TRPA1 ion channel activation context‐dependently regulates gene expression in normal and psoriatic human skin

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Psoriasis is a chronic, relapsing, immune‐mediated inflammatory skin disease. The transient receptor potential ankyrin 1 (TRPA1) ion channel plays a protective role in the formation of psoriasiform skin reactions. Here, we investigated the pharmacological activation and blockade of TRPA1 in human skin (patho)physiology ...
Ágnes Kemény, Szabina Horváth, Júlia Szebényi, Péter Oláh, Viktória Németh, Péter Urbán, József Kun, Attila Gyenesei, Areej Jaber, Erika Pintér, Rolland Gyulai   +10 more
wiley   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh, Nathalie Vermeulen, Carolyn Ee, Helena Teede, Amanda J. Vincent   +4 more
wiley   +1 more source

Pulmonary Artery Aneurysm (PAA) in Behçet's Disease Presenting With Recurrent Hemoptysis: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Pulmonary artery aneurysm is a serious but under‐recognized complication of Behçet's disease that may present with hemoptysis. Early diagnosis coupled with timely initiation of immunosuppressive therapy is crucial in preventing aneurysmal progression and associated life‐threatening complications.
Sorouri S, Safari Farmad M, Amiriani A, Baniasad A.   +3 more
europepmc   +2 more sources

Humeroradial Synostosis: An Updated Classification and Differential Diagnosis Based on Genetic Aetiology

Clinical Genetics, EarlyView.
The proposed updated classification of humeroradial synostosis is based on the molecular pathways of the genes involved: (1) chondrogenesis and osteogenesis; (2) limb development and patterning; (3) genome regulation. Thus, pathologies belonging to the same molecular type may have overlapping clinical phenotypes, helping to structure the diagnostic ...
Fiona Leduc, Clémence Vanlerberghe, Fabienne Escande, Perrine Brunelle, Florence Petit, Anne Dieux   +5 more
wiley   +1 more source

Foetal disruptive brain injuries: Diagnosing the underlying pathogenetic mechanisms with cranial ultrasonography

Developmental Medicine &Child Neurology, EarlyView.
Abstract Antenatal destructive events affecting the central nervous system of the foetus lead to disruptive brain lesions that are often associated with impaired neurodevelopment. The pathogenesis of these lesions encompasses a range of causes, including haemorrhagic, embolic, or other vascular events; exposure to teratogens, such as drugs or substance
Ana Alarcón, Nuria Carreras, Tobias Muehlbacher, Dídac Casas‐Alba, Roberta Arena, Paola Roca‐Llabrés, Juan Navarro‐Morón, Linda S. de Vries, Paul Govaert, the EurUS.Brain group, Thais Agut, Roberta Arena, Ana Alarcón, Juan Arnáez, Marco Bartocci, Isabel Benavente‐Fernández, María Carmen Bravo, Fernando Cabañas, Nuria Carreras, Olivier Claris, Jeroen Dudink, Monica Fumagalli, Alfredo García‐Alix, Paul Govaert, Sandra Horsch, Simón Lubián, Tobias Muehlbacher, Alessandro Parodi, Adelina Pellicer, Luca Ramenghi, Charles C. Roehr, Simone Schwarz, Sylke Steggerda, Eva Valverde   +33 more
wiley   +1 more source

Analysis of the Pathogen Distribution and Antimicrobial Resistance after Plastic Surgery of the Urogenital System. [PDF]

Plast Reconstr Surg Glob Open
Jiang F, Chen Q, Wu Y, Lin J, Su X, Zhuang J, Zhan S.   +6 more
europepmc   +1 more source