Results 191 to 200 of about 75,397 (323)

Posttranslational modifications of phosphodiesterase type 4 enzymes represent novel points for therapeutic targeting

The FEBS Journal, EarlyView.
Enzymes from the phosphodiesterase type 4 family (PDE4) coordinate physiological events driven by the cyclic AMP s(cAMP) signaling pathway by tightly controlling cAMP dynamics in many cell types. Key to this strict regulation is the myriad of posttranslational modifications that alter PDE4 activity, cellular location, and binding partner selection ...
Madihah Hussain, Gonzalo S. Tejeda, George S. Baillie   +2 more
wiley   +1 more source

PARP Inhibitors in Genitourinary Cancer: A New Paradigm Beyond Prostate Cancer

International Journal of Urology, EarlyView.
ABSTRACT Alterations in the homologous recombination repair genes, such as BRCA1 and BRCA2, are prevalent in various cancers, presenting a unique opportunity to develop synthetic lethal strategies that target homologous recombination deficiency (HRD).
Yohei Okuda, Taigo Kato, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Koji Hatano, Atsunari Kawashima, Junko Murai, Norio Nonomura   +8 more
wiley   +1 more source

FEATURES OF THE MICROBIAL SPECTRUM UROGENITAL SYSTEM OF WOMEN WITH RECURRENT PYELONEPHRITIS

, 2017
O. Romanenko, N. Stepanova, А. В. Руденко, V. Kruglikov, L. Lebid, М. Kolesnyk   +5 more
openalex   +2 more sources

The urogenital system of the 20-MM. pig embryo [PDF]

, 1919
Frank Herbert Rose
openalex   +1 more source

Clinical Usefulness of Early Evaluation of the Bacteriological Effect of Antibiotics Administered as Empiric Therapy Using the Fully Automated Urine Particle Analyzer UF‐5000 in Febrile Urinary Tract Infections

International Journal of Urology, EarlyView.
ABSTRACT Objectives Antimicrobial susceptibility test results following urine cultures over 3 days indicate that clinical symptoms and overall patient condition should be closely monitored to ascertain the effectiveness of a specific antibiotic course. A Fully Automated Urine Particle Analyzer UF‐5000 (UF‐5000) was used to detect bacteria in the urine.
Motohiro Taguchi, Masako Kaido, Naoki Toya, Kumiko Yamada, Akihiko Kanematsu, Toeki Yanagi, Shingo Yamamoto   +6 more
wiley   +1 more source

Disease types and pathogenic mechanisms induced by PM2.5 in five human systems: An analysis using omics and human disease databases

Environment International
Atmospheric fine particulate matter (PM2.5) can harm various systems in the human body. Due to limitations in the current understanding of epidemiology and toxicology, the disease types and pathogenic mechanisms induced by PM2.5 in various human systems ...
Shumin Zhang, Xiaomeng Li, Liru Zhang, Zhengliang Zhang, Xuan Li, Yan Xing, John C. Wenger, Xin Long, Zhier Bao, Xin Qi, Yan Han, André S.H. Prévôt, Junji Cao, Yang Chen   +13 more
doaj  

Empirical antibiotic therapy for acute infections of the urogenital system with fluoroquinolone levofloxacin in the practice of a family doctor

, 2017
В. В. Козлов, М. В. Трофімов, Д. А. Ісаєвський   +2 more
openalex   +2 more sources

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Macroscopic demonstration of the male urogenital system with evidence of a direct inguinal hernia utilizing room temperature plastination. [PDF]

Anatomy, 2016
Ruthig VA, Labrash S, Lozanoff S, Ward MA.   +3 more
europepmc   +1 more source

Two new species of stone loaches of the genus Barbatula (Cypriniformes: Nemacheilidae) from Europe with a neotype designation of B. barbatula (Teleostei: Nemacheilidae)

Journal of Fish Biology, EarlyView.
Abstract Ten species of Barbatula are recognised in Europe, west of the Urals: B. barbatula, B. caucasica, B. hispanica, B. leoparda, B. pironae, B. quignardi, B. sturanyi, B. taurica, B. vardarensis and B. zetensis, with B. caucasica and B. taurica formerly considered subspecies of B. barbatula.
Bárbara B. Calegari, Jörg Freyhof, Conor Waldock, Bernhard Wegscheider, Dario Josi, Lukas Rüber, Ole Seehausen   +6 more
wiley   +1 more source