Results 171 to 180 of about 17,246 (259)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Perinephric Myxoid Pseudotumor of Fat: Case Series, Systematic Review of the Literature, Clinical Classification, and Treatment Implications. [PDF]

Kidney Med
Shi X, He Y, Zhou X, Zhang Z, Nie L, Zhang X, Zeng H.   +6 more
europepmc   +1 more source

NRF2/xCT‐Mediated Antioxidant Adaptation Attenuates Apoptosis Induced by ASCT2 Inhibition in Prostate Cancer

Cancer Science, EarlyView.
ASCT2 inhibition induces ROS accumulation and activates NRF2‐dependent xCT upregulation in prostate cancer. This adaptive response partially supports residual cystine acquisition and glutathione synthesis, whereas combined ASCT2 and xCT inhibition disrupts redox compensation and predominantly promotes apoptotic cell death.
Jiaxing Wei, Yasutaka Yamada, Takaaki Tamura, Masahiro Sugiura, Xue Zhao, Meng Ni, Adilan Aierken, Tomokazu Sazuka, Yusuke Imamura, Shinichi Sakamoto   +9 more
wiley   +1 more source

Efficacy of low-dose nalmefene on recovery from general anaesthesia in adult patients: a multicentre randomised controlled study. [PDF]

BMJ Open
Ma X, Liu J, Zhang Y, Li L, Zhang G, Xing L, Huai X, Tang Y, Xie Y, Su D.   +9 more
europepmc   +1 more source

Urinary Small Extracellular Vesicle DNA as a Biomarker for the Non‐Invasive Diagnosis of Bladder Cancer

Cancer Science, EarlyView.
Clinical application scenarios for the diagnosis of BC. A schematic diagram illustrating the use of sEV DNA liquid biopsy technology to differentiate between benign and bladder cancer patients. ABSTRACT Existing diagnostic technologies for bladder cancer (BC) suffer from low sensitivity, low specificity, or a lack of validation.
Tao Wang, Xin Liao, Jiyang Zhang, Xiaoya Xu, Wei Zhang, Xinlin Chen, Xinyu Zhai, Tongtong Zhang, Xiangyang Zhan, Xingyu Mu, Dadong Zhang, Jian Chen, Dongliang Xu, Mingyue Tan   +13 more
wiley   +1 more source

Effect of oral beta-lactam dosing on outcomes of bacteremic Gram-negative urinary tract infections: a real-world analysis. [PDF]

Microbiol Spectr
May SS, Veillette JJ, Butler AM, Olson J, Alzaidi S, Webb BJ.   +5 more
europepmc   +1 more source

Evaluation of Artificial Intelligence as a Decision-Support Tool in Urological Tumor Boards: A Study in Real Clinical Practice. [PDF]

J Clin Med
De la Torre-Trillo J, Yáñez Castillo Y, Melgarejo Segura MT, Carmona Sánchez E, Zambudio Munuera A, Mora-Delgado J, López Luque A.   +6 more
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Multidisciplinary protocol and outcomes in placenta accreta spectrum: a 12 year cohort study. [PDF]

Arch Gynecol Obstet
Luder A, Castel E, Kleinmann N, Mazaki-Tovi S, Lahav-Ezea H, Shvero A, Zilberman DE, Dotan ZA.   +7 more
europepmc   +1 more source