Results 221 to 230 of about 2,136,868 (298)

Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination‐Mediated c‐Myc Degradation

Cancer Science, EarlyView.
Targeted triggering of SORL1 expression through a novel MPOC delivery system could inhibit ccRCC progression through binding to TRIM22 and further promoting ubiquitination‐mediated C‐MYC degradation, thereby facilitating the inhibition of oxidative phosphorylation through transcriptional repression of ACO2 and IDH2.
Keyi Wang, Wei Song, Qi Bai, Shaoze Shen, Xiao Lu, Chenxuan Su, Shi Yang, Yidi Wang, Yu Xia, Rui Zan, Shuai Jiang, Jianming Guo   +11 more
wiley   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Global, regional, and National burden of urologic neoplasms from 1990 to 2021 and future projections to 2050, a comprehensive analysis for global burden of disease. [PDF]

Discov Oncol
Yang Z, Xinyang Y, Xiaoqing X, Yuanfu Q, Xin D.   +4 more
europepmc   +1 more source

Hybrid grading systems improve progression risk stratification in non‐invasive papillary urothelial carcinoma and support a histomorphological continuum of disease progression

Histopathology, EarlyView.
Hybrid grading systems significantly improve progression‐risk stratification in non‐invasive papillary urothelial carcinoma compared with the WHO 2004/2016 binary classification, with most benefit achieved by a Hybrid 3‐Tier framework. These findings support the existence of a histomorphological continuum of progression risk within the conventional ...
Jane K Nguyen, Marcello P Toscano, Jianbo Li, Sean R Williamson, Christopher G Przybycin, Chia‐Sui Kao, Jonathan L Myles, Kristýna Pivovarčíková, Marián Švajdler, Marek Brousil, Mohamed Eltemamy, Laura Bukavina, Venkatesh Krishnamurthi, Christopher Weight, Rebecca A Campbell, Nima Almassi, Reza Alaghehbandan   +16 more
wiley   +1 more source

<i>Mycobacterium abscessus</i> subsp. <i>massiliense</i> Urinary Tract Infection in an Immunocompetent Patient. [PDF]

Chonnam Med J
Kim M, An JH, Yu SH, Kim SE.
europepmc   +1 more source

The Impact of Hidradenitis Suppurativa on Sexual Function: A Multicentered Cross‐Sectional Study

International Journal of Dermatology, EarlyView.
Summary of a multicenter study of 522 patients with hidradenitis suppurativa (HS) evaluating quality of life, disease severity, and sexual function. HS was associated with impaired sexual function in both women and men, with pain identified as a central driver.
Defne Özkoca, Hediye Eker, Dilay Yerlioğlu Ak, Beril Kara Esen, Ali Emre Buğday, Tuğba Tehçi, Neslihan Demirel Öğüt, Ayris Öztürk, Algün Polat Ekinci, Özlem Su Küçük, Erkan Alpsoy, Aslı Tatlıparmak, Esra Adışen, Ecem Etli, Fatma Etgü, Gülhan Aksoy Saraç, Ersoy Acer, Esra Ağaoğlu, Münevver Güven, Zeynep Karaca Ural, Rabia Öztaş Kara, Ahmet Uğur Atılan, Gözde Ulutaş Demirbaş, Gülhan Gürel, Seçil Vural   +24 more
wiley   +1 more source

Urologic malignancy risk with chronic tumor necrosis factor-alpha inhibitor (TNF-I) exposure: a multicenter, retrospective cohort study. [PDF]

World J Urol
Driscoll CB, Rich JM, Yang C, Nicolas J, Isaacson D, Silberman P, Mi X, Ramesh Kumar SKS, Zhang H, Belknap S, Temps WH, Schaeffer EM, Kundu SD.   +12 more
europepmc   +1 more source

Male genital lichen sclerosus

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Male genital lichen sclerosus is driven by chronic, occluded exposure of susceptible genital epithelium to urine, rather than infection or autoimmunity. This review synthesizes clinical, anatomical and molecular evidence showing how microincontinence and occlusion initiate inflammation, fibrosis and carcinogenesis, and explains the curative effect of ...
Georgios Kravvas, Rory Barry, Richard E. Watchorn, Christopher B. Bunker   +3 more
wiley   +1 more source

Capnography With Integrated Pulmonary Index for Preventing Hypoxemia During Pediatric Urologic Surgery Under Sedation: A Randomized Controlled Trial. [PDF]

Med Sci Monit
Wang Y, Liu H, Yang M, Hu X, Yu L, Guo H.   +5 more
europepmc   +1 more source