Results 81 to 90 of about 31,548 (303)

Tumor‐educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation

International Journal of Cancer, EarlyView.
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon, Min‐Kyung Lee, Eunyong Ahn, Heeyeon Kim, Yong Sang Song, Taejin Ahn   +5 more
wiley   +1 more source

An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans

Nature Communications, 2017
The eukaryotic heat shock protein 90 (Hsp90) undergoes an ATP-dependent conformational cycle that is influenced by posttranslational modifications and co-chaperones.
Abbey D. Zuehlke, Michael Reidy, Coney Lin, Paul LaPointe, Sarah Alsomairy, D. Joshua Lee, Genesis M. Rivera-Marquez, Kristin Beebe, Thomas Prince, Sunmin Lee, Jane B. Trepel, Wanping Xu, Jill Johnson, Daniel Masison, Len Neckers   +14 more
doaj   +1 more source

A DNA methylation assay (MPap) using self‐collected tampon versus cytology collection swab for endometrial cancer detection

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate the practicability of self‐collected tampons with the MPap assay for endometrial cancer (EC) detection, by comparing with the results of cervical swabs. Methods A total of 85 women at Tri‐Service General Hospital (TSGH) were included to directly compare the performance of physician‐collected swabs and self‐collected ...
Kuo‐Min Su, Kuo‐Chang Wen, Yi‐Hsin Lin, Po‐Hsuan Su, Lin‐Yu Chen, Hung Cheng Lai   +5 more
wiley   +1 more source

Mechanisms of Urologic Disease.

Archives of Internal Medicine, 1954
Mode of access: Internet.
  +5 more sources

Pelvic venous disorders in women: Diagnosis and management for gynecologists

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Pelvic venous disorders (PeVD) are an underrecognized yet significant cause of chronic pelvic pain (CPP) in reproductive‐aged women, characterized by venous reflux, obstruction, or both. This clinical opinion provides a practical overview of PeVD for gynecologists, outlining its pathophysiology, common presentations, diagnostic approach, and ...
Tiffany Ni, Inbar Friedman, Jessica Smith, Brian Liu, Mary Melchior, Andrew D. Brown   +5 more
wiley   +1 more source

Chronic Colovesical Fistula Leading to Chronic Urinary Tract Infection Resulting in End-Stage Renal Disease in a Chronic Granulomatous Disease Patient

Urology Case Reports, 2017
A 46-year old man with X-linked chronic granulomatous disease (CGD) being followed at the National Institute of Health with uncontrolled CGD colitis who developed chronic colovesical fistula, and end-stage renal disease (ESRD). Despite aggressive medical
M.R. Siddiqui, T. Sanford, A. Nair, C.S. Zerbe, M.S. Hughes, L. Folio, Piyush K. Agarwal, S.J. Brancato   +7 more
doaj   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Impact of perioperative blood transfusions on clinical outcomes in patients undergoing surgery for major urologic malignancies

Therapeutic Advances in Urology, 2019
The association between allogeneic perioperative blood transfusion (PBT) and decreased survival among patients undergoing various oncological surgeries has been established in various malignant diseases, including colorectal, thoracic and hepatocellular ...
Yasmin Abu-Ghanem, Jacob Ramon
doaj   +1 more source

Prune-belly syndrome: an autopsy case report

Autopsy and Case Reports, 2014
Prune-belly syndrome (PBS) is a rare congenital anomaly characterized by a spectrum of mild-to-severe presentations of urinary tract malformations, deficient abdominal wall musculature, and cryptorchidism in male newborns or genital abnormalities in the ...
Marcela Arruda Pereira Silva Vasconcelos, Patrícia Picciarelli de Lima   +1 more
doaj   +1 more source

Integrating Prostate‐Specific Antigen Density and Prostate Imaging Reporting and Data System Scores to Optimize Detection of Clinically Significant Prostate Cancer: A Multivariable Risk Model Approach

Journal of Clinical Laboratory Analysis, EarlyView.
For the detection of clinically significant prostate cancer, incorporating PSA density into PI‐RADS‐based assessment improved clinical net benefit compared with PI‐RADS alone. The addition of DRE and age to this combined model produced only marginal further gain, indicating that most of the incremental clinical value was derived from PSA density rather
Yunus Kayali
wiley   +1 more source