Results 51 to 60 of about 380,997 (339)

The research and progress of organoid in urinary tumors [PDF]

Yixue xinzhi zazhi, 2020
As an emerging 3D in vitro model system, organoids have the advantages of maintaining the original tissue genotype and biological characteristics, and can to some extent simulate the structural relationship between cells and matrix in in-situ tissues, as
Jun-Wen XIAO, Kun HU, Gang-Lin SU, Hao SUN, Yu-Chen LIU   +4 more
doaj   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

The role of the prostate cancer gene 3 urine test in addition to serum prostate-specific antigen level in prostate cancer screening among breast cancer, early-onset gene mutation carriers [PDF]

, 2015
Objective: To evaluate the additive value of the prostate cancer gene 3 (PCA3) urine test to serum prostate-specific antigen (PSA) in prostate cancer (PC) screening among breast cancer, early-onset gene (BRCA) mutation carriers.
Aaronson, N.K. (Neil), Ardem-Jones, A., Asperen, C.J. (Christi) van, Bancroft, E.K. (Elizabeth), Bancroft, E.K. (Elizabeth), Bangma, C.H. (Chris), Castro, E. (Elena), Cremers, R.G.H.M. (Ruben), Dearnaley, D. (David), Eccles, D. (Diana), Eeles, R. (Rosalind), Eeles, R. (Rosalind), Evans, D.G. (Gareth), Eyfjord, J., Falconer, A., Foster, C.S. (Christopher), Grönberg, H. (Henrik), Hamdy, F. (Freddie), Johansson, O., Khoo, V., Kiemeney, L.A.L.M. (Bart), Kote-Jarai, Z., Lilja, H. (Hans), Lubinski, J. (Jan), Maehle, L., Melia, J., Mikropoulos, C., Mitchell, G. (Gillian), Mitra, A. (Anita), Moss, S.M. (Sue), Moynihan, C., Page, E. (Elizabeth), Rennert, G. (Gad), Ringelberg-Borsboom, J. (Janneke), Schalken, J.A. (Jack), Suri, M. (Mohnish), Vasen, H. (Hans), Verhaegh, G. (Gerald), Wilson, P.   +38 more
core   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Surgical management for upper urinary tract transitional cell carcinoma [PDF]

, 2011
Background Upper tract transitional cell carcinomas (TCC) are uncommon and aggressive tumours. There are a number of surgical approaches to manage this condition including open radical nephroureterectomy and laparoscopic procedures.
Biyani, Chandra S., Coles, Bernadette, El-Mokadem, Ismail, Nabi, Ghulam, Rai, Bhavan Prasad, Shelley, Mike   +5 more
core   +3 more sources

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

Advanced Science, EarlyView.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu, Tianyang Wu, Jiayi Wang, Xinxing Du, Xinrui Wu, Yanhao Dong, Zehong Peng, Penghui Liao, Zirui Guo, Zheyu Liu, Kenneth J Pienta, Yinjie Zhu, Jiahua Pan, Liang Dong, Wei Xue   +14 more
wiley   +1 more source

A case of primary renal oncocytic tumor: Chromophobe renal cell carcinoma or oncocytoma?

IJU Case Reports, 2023
Introduction “Other oncocytic renal tumors of the kidney” is a new category constituted by 2022 WHO classification and different in the point of morphology and immunohistochemistory from typical oncocytic/eosinophilic renal tumors including chromophobe ...
Kenta Matsui, Katsunori Uchida, Masahiro Kanai, Kana Asakawa, Miki Usui, Tetsuya Murata   +5 more
doaj   +1 more source

Is moderate hypofractionation accepted as a new standard of care in north america for prostate cancer patients treated with external beam radiotherapy? Survey of genitourinary expert radiation oncologists [PDF]

, 2019
INTRODUCTION: Several recent randomized clinical trials have evaluated hypofractionated regimens against conventionally fractionated EBRT and shown similar effectiveness with conflicting toxicity results.
Chen, Yiyi, Degnin, Catherine, Hung, Arthur Y., McClelland, Shearwood, Mitin, Timur, Sandler, Kiri A.   +5 more
core   +2 more sources

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Succinate dehydrogenase (SDH)-deficient renal carcinoma:a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients [PDF]

, 2014
Succinate dehydrogenase (SDH)-deficient renal carcinoma has been accepted as a provisional entity in the 2013 International Society of Urological Pathology Vancouver Classification.
Belinsky, Cascon, Cascon, Chou, Dwight, Dwight, Eng, Fairchild, Fishbein, Fleming, Gaal, Gill, Gill, Gill, Gill, Gill, Gill, Gill, Gill, Gimm, Henderson, Housley, Janeway, Jasperson, Korpershoek, Malinoc, Miettinen, Miettinen, Miettinen, Neumann, Ni, Oudijk, Paik, Papathomas, Ricketts, Ricketts, Said-Al-Naief, Schimke, Solis, Srigley, Srirangalingam, Srirangalingam, van Nederveen, van Nederveen, Vanharanta, Wagner, Xekouki   +46 more
core   +4 more sources