Results 51 to 60 of about 15,266 (342)

Engineering CRISPR System‐Based Bacterial Outer Membrane Vesicle Potentiates T Cell Immunity for Enhanced Cancer Immunotherapy

Advanced Materials, EarlyView.
This study develops a multifunctional CRISPR‐dCas9‐based OMV platform termed OMV‐C9I12, which facilitates the coexpression of CXCL9 and IL‐12 within tumor cells. This platform enhances T cell recruitment and activation, synergizes with anti‐PD‐1/PD‐L1 immunotherapy, and amplifies antitumor T cell immunity.
Hongjin Wang, Hengji Zhan, Bolin Pan, Leli Zeng, Zehua Chen, Sen Liu, Qiang Zhang, Xuwei Hong, Junlin Lu, Xinrou Lin, Xiao Zhao, Jiajian Lai, Kaiwen Jie, Ye Li, Jianmei Zhong, Shengmeng Peng, Siting Chen, Changhao Chen, Wenlong Zhong, Shaoxu Wu, Yihang Pan, Tianxin Lin, Xu Chen   +22 more
wiley   +1 more source

Primary signet‐ring cell carcinoma of the renal pelvis: An autopsy case

IJU Case Reports, 2022
Introduction Signet‐ring cell carcinoma is an extremely rare histological variant of upper urinary tract carcinoma, associated with poor prognosis. Case presentation We report a case of a 75‐year‐old female diagnosed with left primary upper urinary tract
Heisuke Iijima, Hiroaki Murata, Shinnosuke Oishi, Yusuke Kubota, Akihiko Sakamoto, Kuniaki Tanabe, Kazutaka Sugiyama, Akihiko Matsumoto, Ken Kuriki, Haruki Kume   +9 more
doaj   +1 more source

SMYD3 Promotes Immune Evasion in Clear Cell Renal Cell Carcinoma via SREBP1‐Mediated Transactivation of CD47

Advanced Science, EarlyView.
Cancer cell‐intrinsic SMYD3 orchestrates an immunosuppressive microenvironment and impairs the response to PD‐1 blockade by reprogramming immune cells landscape in the tumor microenvironment of clear cell renal cell carcinoma (ccRCC). The immunomodulatory function of SMYD3 is mediated via the SREBP1/CD47 pathway.
Zhengfang Liu, Xiumei Zhao, Maolin Zang, Huiyang Yuan, Xin Qin, Xiaofeng Li, Shuo Zhao, Ruirong Tan, Keqiang Yan, Li Liu, Yidong Fan, Ning Zhang, Benkang Shi, Bo Han, Shouzhen Chen   +14 more
wiley   +1 more source

The application of the Johns Hopkins Hospital Template on urine cytology [PDF]

, 2015
Background To evaluate the utility of the Johns Hopkins Hospital (JHH) template in detection of high-grade urothelial carcinoma (HGUC). Methods A computerized search of our laboratory information system was performed for all urine cytology cases ...
Chen, Shaoxiong, Cramer, Harvey M., Grignon, David J., Redelman, Megan, Wu, Howard H.   +4 more
core   +1 more source

Radiomics‐Based Unsupervised Clustering Identifies Subtypes Associated With Prognosis and Immune Microenvironment in Clear Cell Renal Cell Carcinoma: A Multicenter Study

Advanced Science, EarlyView.
This study developed an unsupervised radiomics system integrating CT imaging and multi‐omics data to stratify clear cell renal cell carcinoma into two subtypes with distinct clinical outcomes. Cluster 1 showed lower recurrence risk and active immunity, while Cluster 2 exhibited higher recurrence risk, enriched VHL/KDM5C mutations, immunosuppressive ...
Yusheng Guo, Bingxin Gong, Yi Li, Jie Lou, Shuai Shan, Xiaodong Zhang, Qiang Lu, Dongyong Zhu, Qing Sun, Lianwei Miao, Yuanxi Li, Yu‐Dong Zhang, Wei Tan, Lian Yang, Chuansheng Zheng   +14 more
wiley   +1 more source

Exosomal CCT6A Secreted by Cancer‐Associated Fibroblasts Interacts with β‐Catenin to Enhance Chemoresistance and Tumorigenesis in Gastric Cancer

Advanced Science, EarlyView.
Here, it is revealed that CAF‐secreted exosomal CCT6A enhances stemness, chemoresistance, and glycolysis in GC via the β‐catenin/c‐Myc/DDIT4‐TXNIP axis. Furthermore, CCT6P1, a pseudogene of CCT6A, is identified as upregulating CCT6A by competitively binding miR‐922, while c‐Myc transcriptionally activates both CCT6P1 and CCT6A.
Hui Sun, Tianqi Zhang, Xiaoyan Zhang, Yingxue Liu, Xu Wang, Xin Wang, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Xiaoyu Wang, Wenfeng Wang, Weiqi Sheng, Mi‐die Xu   +15 more
wiley   +1 more source

High Apoptotic Index in Urine Cytology Is Associated with High-Grade Urothelial Carcinoma [PDF]

, 2016
BACKGROUND The significance of apoptosis and its association with high-grade urothelial carcinoma (HGUC) in urine cytology has yet to be determined.
Chen, Shaoxiong, Cramer, Harvey M., Wu, Howard H., Yang, Chi-Shun   +3 more
core   +1 more source

Biodegradable Medical Implants: Reshaping Future Medical Practice

Advanced Science, EarlyView.
Biodegradable medical implants are transforming future healthcare by providing sustainable, biocompatible solutions that eliminate secondary removal procedures, enhancing patients’ physical and psychological comfort, and reducing economic burdens.
Bo Xia, Yan Liu, Yangkun Xing, Zhewei Shi, Xiaocheng Pan   +4 more
wiley   +1 more source

Hematuria in anticoagulated patients with atrial fibrillation and urologic cancer

Research and Practice in Thrombosis and Haemostasis, 2022
Background Based on their renal excretion, direct oral anticoagulants (DOACs) may increase the risk of hematuria in patients with atrial fibrillation (AF) and urologic cancer compared with vitamin K antagonists. Objectives To examine the risk of bleeding
Anne Gulbech Ording, Mette Søgaard, Flemming Skjøth, Erik Lerkevang Grove, Gregory Y. H. Lip, Torben Bjerregaard Larsen, Peter Brønnum Nielsen   +6 more
doaj   +1 more source

microRNA. Diagnostic Perspective [PDF]

, 2015
Biomarkers are biological measures of a biological state. An ideal marker should be safe and easy to measure, cost efficient, modifiable with treatment, and consistent across gender and ethnic groups. To date, none of the available biomarkers satisfy all
FARUQ, MD OMAR, VECCHIONE, ANDREA
core   +2 more sources