Results 131 to 140 of about 361,421 (310)

Multi‐Stimuli Responsive Magneto‐Coacervate Droplets for Selective Molecular Enrichment and Programmable Manipulation

Advanced Science, EarlyView.
ABSTRACT Coacervate droplets formed via liquid–liquid phase separation offer unique opportunities as microreactors and delivery vehicles due to their ability to selectively concentrate biomolecules and support biochemical reactions. However, their passive nature severely restricts precise spatial and temporal control, posing barriers to practical ...
Kailang Liu, Haocheng Ran, Haohui Ou, Peiying Chen, Cheng Qi, Tiantian Kong, Zhou Liu   +6 more
wiley   +1 more source

Early PIVKA-II Response Associated with Treatment Efficacy and Survival Outcomes for Patients with Advanced Hepatocellular Carcinoma Receiving Immune Checkpoint Inhibitors and Targeted Therapy

Journal of Hepatocellular Carcinoma
Zheng-Kang Fang,1,2 Yu-Ting Xiao,1 Xia Feng,1 Zhe-Jin Shi,1,3 Si-Yu Liu,4 Yang Yu,5 Li-Ming Jin,1 Dong-Sheng Huang,1 Cheng-Wu Zhang,1 Jun-Wei Liu,1 Lei Liang1 1Department of General Surgery, Cancer Center, Hepatobiliary & Pancreatic Surgery and ...
Fang ZK, Xiao YT, Feng X, Shi ZJ, Liu SY, Yu Y, Jin LM, Huang DS, Zhang CW, Liu JW, Liang L   +10 more
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Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Investigating Causal Links Between Uterine Prolapse, Urinary Tract Infections, and Lower Urinary Tract Symptoms: A Two-Sample Mendelian Randomization Study

International Journal of Women's Health
Xiaoyue Zhu, Chunyan Hu, Anneng Hu, Yongbo Zheng, Junyang Li, Fuwen Luo, Lin Yang, Yuhang Lin, Xiaodong Yu Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of ChinaCorrespondence: Xiaodong ...
Zhu X, Hu C, Hu A, Zheng Y, Li J, Luo F, Yang L, Lin Y, Yu X   +8 more
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LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Research Status of Androgen Deprivation Therapy Monotherapy and Combination Therapy for Prostate Cancer: A Scoping Review

Cancer Management and Research
Xiaolin Lu,1,2 Xiaojie Bian,1,2 Shanshan Wang,1,2 Dingwei Ye1,2 1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s
Lu X, Bian X, Wang S, Ye D
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TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Nanodynamic Therapy in Colorectal Cancer: Engineering Precision Immunotherapy and Multimodal Synergy

International Journal of Nanomedicine
Feng Wang,1,* Zhongsong Zhang,2,* Junhao Chen,3,* Lingrong Qian,1,* Bo Chen,4,* Lumei Zhai,5 Junxian Zhao,6 Tianze Chen,7 Jingfeng Zhou,2 Keyi Gou,2 Zihan Zhao,2 Xingcheng Zhu,8 Zhiyuan Xiao1 1Gastrointestinal ...
Wang F, Zhang Z, Chen J, Qian L, Chen B, Zhai L, Zhao J, Chen T, Zhou J, Gou K, Zhao Z, Zhu X, Xiao Z   +12 more
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CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

Advanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen, Sixuan Cheng, Jian Shi, Ruijie Liu, Yilong Wu, Xin Zheng, Xinlun Song, Yunxuan Zhang, Lei Liu, Zhihao Wei, Qi Wang, Xinwei Li, Zirui Dong, Yuenan Liu, Hongmei Yang, Xiaoli Lan, Chunxia Qin, Dawei Jiang, Keshan Wang, Xiaoping Zhang   +19 more
wiley   +1 more source

On Exposure Definition and Temporal Interpretation in the Reported Association Between Number of Pregnancies and Rheumatoid Arthritis [Letter]

International Journal of Women's Health
Wang Lei,1,2 Zhihui Li,1,2 Liang Zhong,1,2 Dongxiang Zheng1,2 1The Tenth Clinical Medical College of Guangzhou University of Chinese Medicine, Zhongshan, Guangdong, People’s Republic of China; 2Zhongshan Hospital of Traditional Chinese Medicine,
Wang L, Li Z, Zhong L, Zheng D
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