Results 131 to 140 of about 420,448 (359)

Association of High Tumor-Stroma Ratio with Prostate Cancer Progression: Insights from Clinical and Genomic Data

International Journal of General Medicine
Wenbo Xu,1,2 Qian Niu,3 Kun Zhao,1,2 Haozhi Zhao,1,2 Long Zhang,1,2 Wenxuan Li,1,2 Hong Yan,3 Zhilong Dong1,2 1Institute of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital & Clinical Medical School ...
Xu W, Niu Q, Zhao K, Zhao H, Zhang L, Li W, Yan H, Dong Z   +7 more
doaj  

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Comments on “Association Between Cardiovascular Health (Life’s Crucial 9) and Stress Urinary Incontinence in Women: The Mediating Role of Oxidative Stress Factors (NHANES 2005–2018)” [Letter]

International Journal of Women's Health
Lei Wang,1,2 Zhihui Li,1,2 Liang Zhong,1,2 Dongxiang Zheng1,2 1The Tenth Clinical Medical College of Guangzhou University of Chinese Medicine, Zhongshan, Guangdong, People’s Republic of China; 2Zhongshan Hospital of Traditional Chinese Medicine,
Wang L, Li Z, Zhong L, Zheng D
doaj  

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Multi-Omics Analysis Reveals m7G Methylation-Related Genes May Be Involved in TGF-β Signaling-Mediated Anti-PD-L1 Response in Bladder Cancer

ImmunoTargets and Therapy
Hai-Qi Liang,1,* Yu-Jian Li,1,* Jia-Yin Yu,1,* Qi-Zhou Mo,1 Qiu-Ju Wei,2 Yu-Qi Liang,2 Fa-Ye Wei,1 Xiao-Ping Zhang,3 Jia-Wen Zhao,1 Yu-Xian He,2 Xin-Dong Feng,2 Bin-Tong Yin,1 Xin-Wen Liang,1 Ren-Jun Nong,1 Yao-Yu Wang,1 Min Qin,4
Liang HQ, Li YJ, Yu JY, Mo QZ, Wei QJ, Liang YQ, Wei FY, Zhang XP, Zhao JW, He YX, Feng XD, Yin BT, Liang XW, Nong RJ, Wang YY, Qin M, Cheng JW   +16 more
doaj  

The Role of Urodynamics in the Evaluation of Urinary Incontinence: The European Association of Urology Recommendations in 2016

, 2017
This article summarises the European Association Urology guidelines position on the role of urodynamic studies in investigating the problem of urinary incontinence. The guidelines recommend that urodynamics should not be necessary to help decide the best
Nambiar, Arjun K, European Association, of Urology, Chapple, Christopher R, Lemack, Gary E, Burkhard, Fiona C.   +4 more
core   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

IL-6/IL-6R Signaling Blockade Alleviates Chronic Allograft Rejection by Modulating Germinal Center B Cells and Allograft Inflammation in Murine Cardiac Transplantation

Journal of Inflammation Research
Renfei Xia,1,* Xiaoyi Shi,2,* Hengcheng Zhang,3,* Wenli Zeng,1 Zhe Yang,4 Jian Xu,1 Jianning Wang,4 Yun Miao,1 Tao Liao1,4 1Department of Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s ...
Xia R, Shi X, Zhang H, Zeng W, Yang Z, Xu J, Wang J, Miao Y, Liao T   +8 more
doaj  

SHORT-TERM COMPLICATIONS OF TRANSURETHRAL RESECTION OF THE PROSTATE PERFORMED BY UROLOGY RESIDENT IN EDUCATIONAL HOSPITAL: CHARACTERISTICS AND DETERMINANT FACTORS

Objective: This research wanted to figure out the characteristics and determinant factors of short-term complications of TURP performed by urology resident in educational hospital.
Daryanto, Besut, Meiyanto, Johanes Dwi, Budaya, Taufiq Nur   +2 more
core   +1 more source

Artificial Intelligence in Reproductive Urology

, 2019
The promise of artificial intelligence (AI) in medicine has been widely theorized over the past couple of decades. It has only been with technological advances over the past few years that physicians and computer scientists have started discovering its ...
Chu, Kevin Y, Lokeshwar, Soum D, Arora, Himanshu, Nassau, Daniel E, Ramasamy, Ranjith, Madhusoodanan, Vinayak   +5 more
core   +1 more source