Results 111 to 120 of about 420,448 (359)

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Retrospective outcome analysis of urethroplasties performed for various etiologies in a single South African centre

, 2012
This is the author’s version of a work that was accepted for publication of the article: African Journal of Urology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality ...
Naudé, J.H., Lazarus, John, Wiechers, L, Van Den Heever, A P, J. Lazarus, Naudé, JH, van den Heever, AP, Tsheisi, M., Tsheisi, M, Lazarus, J., A.P. van den Heever, Lazarus, J, Wiechers, L., Naude, J H, L. Wiechers, M. Tsheisi, van den Heever, A.P., J.H. Naudé   +17 more
core   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

Venous thromboembolism: A problem in the Indian/Asian population?

Indian Journal of Urology, 2009
Venous thromboembolism (VTE) is a common and potentially life threatening condition. It continues to be under diagnosed and undertreated. Awareness among Indians regarding this potentially life-threatening disease is low.
Sunil Agarwal, Arvind Dhas Lee, Ravish Sanghi Raju, Edwin Stephen   +3 more
doaj   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

EFFICACY OF ALFUZOSIN VERSUS CONTROL GROUP IN UPPER URETERIC STONE EXPULSION IN ADULT POPULATION OF LAHORE, PAKISTAN

Gomal Journal of Medical Sciences, 2022
Background: Urinary stone disease is one of the commonest urological diseases worldwide. The objective of this study was to compare the efficacy of alfuzosin versus control group in upper ureteric stone expulsion in adult population of district Lahore ...
Fawad Humayun, Ghulam Mujtaba, Muhammad Seerwan, Ghazi Khan, Naseem Javed, Muhammad Adnan   +5 more
doaj  

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

RNA Binding Motif Protein 15 (RBM15): Structure, Function and Its Research Progress in Tumors

International Journal of General Medicine
Xiangyu Long,* Bintao Hu,* Shiqing Zhu, Yue Wu, Tao Wang Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China*These authors ...
Long X, Hu B, Zhu S, Wu Y, Wang T
doaj  

Achieving sustainability in urology:a consensus study by the European association of urology (EAU) section office

PURPOSE: To assess the awareness, attitudes, and practices related to environmental sustainability among urologists and to explore targeted interventions, educational initiatives to enhance sustainability in urological practice while maintaining high ...
Güven, Selçuk, Ralph, David, Akgül, Burak, Finazzi Agro, Enrico, Bettocchi, Carlo, Soytürk, Selim, Sönmez, Mehmet Giray, Sanguedolce, Francesco, Herrmann, Thomas R. W., Roupret, Morgan, Gadzhiev, Nariman, Vasquez, Juan Luis, Mallet, Richard, Aydın, Abdullatif, Rassweiler, Jens, Knoll, Thomas, Keller, Etienne Xavier, Ahmed, Kamran, Tozsin, Atınç, Colecchia, Maurizio, Musquera, Mireia, Omar, Muhammad Imran, Traxer, Olivier, Dasgupta, Prokar, Arslan, Erkan, Pradere, Benjamin, Çakır, Ömer Onur, Tunç, Lütfi, Herrmann, Thomas R W, Sılay, Selçuk Mesrur   +29 more
core   +1 more source