Results 111 to 120 of about 361,421 (310)

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

Prospective Evaluation of Postoperative SIRS and Serum Inflammatory Indices in Percutaneous Nephrolithotomy Patients

Therapeutics and Clinical Risk Management
Yusuf Bugra Arslantas,1 Gokhan Sonmez,2 Numan Baydilli,2 Unsal Bas,3 Halil Tosun,2 Deniz Demirci,2 Emre Can Akinsal2 1Urology Clinic, Viransehir State Hospital, Sanliurfa, Türkiye; 2Department of Urology, Erciyes University Faculty of Medicine, Kayseri ...
Arslantas YB, Sonmez G, Baydilli N, Bas U, Tosun H, Demirci D, Akinsal EC   +6 more
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CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Secondary Analysis of PSA and BCR-Free Survival in Asian Prostate Cancer Patients

Cancer Management and Research
Xin Gao,1,* Yijun Fu,1,* Zimei Mo,1 Yongtong Ruan2 1Department of Urology, Yangjiang Hospital of Traditional Chinese Medicine, Affiliated to Guangzhou University of Chinese Medicine, Yangjiang, Guangdong, People’s Republic of China ...
Gao X, Fu Y, Mo Z, Ruan Y
doaj  

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Comments on “Association Between Cardiovascular Health (Life’s Crucial 9) and Stress Urinary Incontinence in Women: The Mediating Role of Oxidative Stress Factors (NHANES 2005–2018)” [Letter]

International Journal of Women's Health
Lei Wang,1,2 Zhihui Li,1,2 Liang Zhong,1,2 Dongxiang Zheng1,2 1The Tenth Clinical Medical College of Guangzhou University of Chinese Medicine, Zhongshan, Guangdong, People’s Republic of China; 2Zhongshan Hospital of Traditional Chinese Medicine,
Wang L, Li Z, Zhong L, Zheng D
doaj  

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Multi-Omics Analysis Reveals m7G Methylation-Related Genes May Be Involved in TGF-β Signaling-Mediated Anti-PD-L1 Response in Bladder Cancer

ImmunoTargets and Therapy
Hai-Qi Liang,1,* Yu-Jian Li,1,* Jia-Yin Yu,1,* Qi-Zhou Mo,1 Qiu-Ju Wei,2 Yu-Qi Liang,2 Fa-Ye Wei,1 Xiao-Ping Zhang,3 Jia-Wen Zhao,1 Yu-Xian He,2 Xin-Dong Feng,2 Bin-Tong Yin,1 Xin-Wen Liang,1 Ren-Jun Nong,1 Yao-Yu Wang,1 Min Qin,4
Liang HQ, Li YJ, Yu JY, Mo QZ, Wei QJ, Liang YQ, Wei FY, Zhang XP, Zhao JW, He YX, Feng XD, Yin BT, Liang XW, Nong RJ, Wang YY, Qin M, Cheng JW   +16 more
doaj  

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Association of High Tumor-Stroma Ratio with Prostate Cancer Progression: Insights from Clinical and Genomic Data

International Journal of General Medicine
Wenbo Xu,1,2 Qian Niu,3 Kun Zhao,1,2 Haozhi Zhao,1,2 Long Zhang,1,2 Wenxuan Li,1,2 Hong Yan,3 Zhilong Dong1,2 1Institute of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital & Clinical Medical School ...
Xu W, Niu Q, Zhao K, Zhao H, Zhang L, Li W, Yan H, Dong Z   +7 more
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