Results 111 to 120 of about 450,591 (305)

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

Bladder Leiomyoma Presenting with Recurrent Cystitis: A Case Report

Research and Reports in Urology
Kazuhiro Fukuda,1 Satoru Kotoda,1 Kaori Fukaya,1 Eisuke Yokota,1 Shigetaka Yamasaki,2 Shigeo Horie3,4 1Department of Urology, Koshigaya Municipal Hospital, Koshigaya, Saitama, Japan; 2Department of Pathology, Tokyo Rinkai Hospital, Tokyo, Japan ...
Fukuda K, Kotoda S, Fukaya K, Yokota E, Yamasaki S, Horie S   +5 more
doaj  

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

Advanced Science, EarlyView.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou, Ke Li, Xuelan Li, Lei Yi, Zhengxiang Wang, Huan Ding, Sheng Wu, Feiyu Liu, Yuan Li, Rui Cheng, Jianliang Shen   +10 more
wiley   +1 more source

Early PIVKA-II Response Associated with Treatment Efficacy and Survival Outcomes for Patients with Advanced Hepatocellular Carcinoma Receiving Immune Checkpoint Inhibitors and Targeted Therapy

Journal of Hepatocellular Carcinoma
Zheng-Kang Fang,1,2 Yu-Ting Xiao,1 Xia Feng,1 Zhe-Jin Shi,1,3 Si-Yu Liu,4 Yang Yu,5 Li-Ming Jin,1 Dong-Sheng Huang,1 Cheng-Wu Zhang,1 Jun-Wei Liu,1 Lei Liang1 1Department of General Surgery, Cancer Center, Hepatobiliary & Pancreatic Surgery and ...
Fang ZK, Xiao YT, Feng X, Shi ZJ, Liu SY, Yu Y, Jin LM, Huang DS, Zhang CW, Liu JW, Liang L   +10 more
doaj  

Ureteroscopic treatment of larger renal calculi (\u3e2 cm). [PDF]

, 2012
OBJECTIVES: To evaluate the current status of ureteroscopic lithotripsy (UL) for treating renal calculi of \u3e2 cm, as advances in flexible ureteroscope design, accessory instrumentation and lithotrites have revolutionised the treatment of urinary ...
Bagley, Demetrius H., Healy, Kelly A., Kleinmann, Nir   +2 more
core   +1 more source

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Investigating Causal Links Between Uterine Prolapse, Urinary Tract Infections, and Lower Urinary Tract Symptoms: A Two-Sample Mendelian Randomization Study

International Journal of Women's Health
Xiaoyue Zhu, Chunyan Hu, Anneng Hu, Yongbo Zheng, Junyang Li, Fuwen Luo, Lin Yang, Yuhang Lin, Xiaodong Yu Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of ChinaCorrespondence: Xiaodong ...
Zhu X, Hu C, Hu A, Zheng Y, Li J, Luo F, Yang L, Lin Y, Yu X   +8 more
doaj  

Toward Prostate Cancer Early Warning with a Self‐Powered Wearable Biosensing Platform Integrated with Machine Learning

Advanced Science, EarlyView.
ABSTRACT Current prostate cancer detection methods remain limited in non‐invasiveness and specificity, prompting interest in urinary biomarkers such as sarcosine. Here, we report a urine‐powered wearable platform for non‐invasive sarcosine detection as a proof‐of‐concept for decentralized early warning.
Jing Xu, Hanxiao Chen, Qichen Yuan, Liucun Yin, Yifang Tao, Hong Wang, Yuquan Xue, Delai Fu, Huan Pang, Tie Chong, Li Xue   +10 more
wiley   +1 more source

Research Status of Androgen Deprivation Therapy Monotherapy and Combination Therapy for Prostate Cancer: A Scoping Review

Cancer Management and Research
Xiaolin Lu,1,2 Xiaojie Bian,1,2 Shanshan Wang,1,2 Dingwei Ye1,2 1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s
Lu X, Bian X, Wang S, Ye D
doaj  

Metastatic Renal Cell Carcinoma (RCC) [PDF]

, 1991
A. V. Bono, C. Stief, D. E. Johnson, D. G. Skinner, D. H. Garfield, D. J. Fairlamb, D. W. McNichols, E. Allhoff, G. L. Rohdenburg, G. T. Hultquist, H. C. Bumpus Jr., H. E. Stephenson Jr., H. J. G. Bloom, H. J. G. Bloom, H. J. G. Bloom, H. Takatera, I. Satake, J. B. Kernion De, J. B. Kernion De, J. C. Donaldson, J. E. Montie, K. Goldenberg, L. R. Kavoussi, M. M. Mims, R. C. Klugo, R. G. Middleton, R. M. Snow, R. Schlick, S. E. Katz, S. Liedke, S. Z. Freed, T. C. Everson, U. Jonas, W. de Riese, Z. Wajsman   +34 more
core   +1 more source