Results 101 to 110 of about 450,591 (305)

Comments on “Association Between Cardiovascular Health (Life’s Crucial 9) and Stress Urinary Incontinence in Women: The Mediating Role of Oxidative Stress Factors (NHANES 2005–2018)” [Letter]

International Journal of Women's Health
Lei Wang,1,2 Zhihui Li,1,2 Liang Zhong,1,2 Dongxiang Zheng1,2 1The Tenth Clinical Medical College of Guangzhou University of Chinese Medicine, Zhongshan, Guangdong, People’s Republic of China; 2Zhongshan Hospital of Traditional Chinese Medicine,
Wang L, Li Z, Zhong L, Zheng D
doaj  

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Multi-Omics Analysis Reveals m7G Methylation-Related Genes May Be Involved in TGF-β Signaling-Mediated Anti-PD-L1 Response in Bladder Cancer

ImmunoTargets and Therapy
Hai-Qi Liang,1,* Yu-Jian Li,1,* Jia-Yin Yu,1,* Qi-Zhou Mo,1 Qiu-Ju Wei,2 Yu-Qi Liang,2 Fa-Ye Wei,1 Xiao-Ping Zhang,3 Jia-Wen Zhao,1 Yu-Xian He,2 Xin-Dong Feng,2 Bin-Tong Yin,1 Xin-Wen Liang,1 Ren-Jun Nong,1 Yao-Yu Wang,1 Min Qin,4
Liang HQ, Li YJ, Yu JY, Mo QZ, Wei QJ, Liang YQ, Wei FY, Zhang XP, Zhao JW, He YX, Feng XD, Yin BT, Liang XW, Nong RJ, Wang YY, Qin M, Cheng JW   +16 more
doaj  

m5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

Advanced Science, EarlyView.
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji   +16 more
wiley   +1 more source

IL-6/IL-6R Signaling Blockade Alleviates Chronic Allograft Rejection by Modulating Germinal Center B Cells and Allograft Inflammation in Murine Cardiac Transplantation

Journal of Inflammation Research
Renfei Xia,1,* Xiaoyi Shi,2,* Hengcheng Zhang,3,* Wenli Zeng,1 Zhe Yang,4 Jian Xu,1 Jianning Wang,4 Yun Miao,1 Tao Liao1,4 1Department of Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s ...
Xia R, Shi X, Zhang H, Zeng W, Yang Z, Xu J, Wang J, Miao Y, Liao T   +8 more
doaj  

Assessing somatization in urologic chronic pelvic pain syndrome [PDF]

, 2019
BACKGROUND: This study examined the prevalence of somatization disorder in Urological Chronic Pelvic Pain Syndrome (UCPPS) and the utility of two self-report symptom screening tools for assessment of somatization in patients with UCPPS.
Alpers, D H, Hong, B A, Lai, H H, North, C S   +3 more
core   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

A Pan-Cancer Analysis of Natriuretic Peptide Receptor 3 (NPR3) with Clinical Cohort and in vitro Validation

Journal of Inflammation Research
Yifan Liu,1,* Jiangui Liu,1,* Yuanan Li,1,* Zihui Zhao,1,* Donghao Lyu,1 Keqin Dong,1 Maodong Wei,1 Runzhi Huang,2 Bingnan Lu,1 Xiuwu Pan1 1Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University
Liu Y, Liu J, Li Y, Zhao Z, Lyu D, Dong K, Wei M, Huang R, Lu B, Pan X   +9 more
doaj  

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

NRF2 Deficiency in Bladder Epithelial Cells Owing to Ubiquitination by N6-Methyladenosine-Modified TRIM21 Induces Oxidative Stress and Inflammation to Aggravate IC/BPS

Journal of Inflammation Research
Zongyao Fan,1,* Qingyu Ge,2,* Bin Ni,1,* Junjie Zhang,1 Tianpeng Du,1 Hewei Xu,3 Zheng Duan,1 Sicong Zhang,1 Chao Wang,4 Jun Xue,1 Feng Ling,5 Zhengsen Chen,1 Baixin Shen,1 Zhongqing Wei1 1Department of Urology, The Second ...
Fan Z, Ge Q, Ni B, Zhang J, Du T, Xu H, Duan Z, Zhang S, Wang C, Xue J, Ling F, Chen Z, Shen B, Wei Z   +13 more
doaj