Results 91 to 100 of about 382,165 (310)

Targeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer

Advanced Science, EarlyView.
A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong   +15 more
wiley   +1 more source

Metagenomic Characterization of Nitrite-Negative Urinary Tract Infections and Identification of an optrA-fexA Co-Localization in a Primary Healthcare Setting in China

Infection and Drug Resistance
Jie Chen,1,2,* Yuhan Guan,1,2,* Wenqin Li,2,* Yongxing Bao,2 Zhaoer Wang,2 Zhikang Sun,3 Xing Hu,4 Haihong Jiang51General Department, Jiashan County Huimin Street Community Health Service Center, Jiaxing, Zhejiang, People’s ...
Chen J, Guan Y, Li W, Bao Y, Wang Z, Sun Z, Hu X, Jiang H   +7 more
doaj  

Achieving sustainability in urology:a consensus study by the European association of urology (EAU) section office

PURPOSE: To assess the awareness, attitudes, and practices related to environmental sustainability among urologists and to explore targeted interventions, educational initiatives to enhance sustainability in urological practice while maintaining high ...
Güven, Selçuk, Ralph, David, Akgül, Burak, Finazzi Agro, Enrico, Bettocchi, Carlo, Soytürk, Selim, Sönmez, Mehmet Giray, Sanguedolce, Francesco, Herrmann, Thomas R. W., Roupret, Morgan, Gadzhiev, Nariman, Vasquez, Juan Luis, Mallet, Richard, Aydın, Abdullatif, Rassweiler, Jens, Knoll, Thomas, Keller, Etienne Xavier, Ahmed, Kamran, Tozsin, Atınç, Colecchia, Maurizio, Musquera, Mireia, Omar, Muhammad Imran, Traxer, Olivier, Dasgupta, Prokar, Arslan, Erkan, Pradere, Benjamin, Çakır, Ömer Onur, Tunç, Lütfi, Herrmann, Thomas R W, Sılay, Selçuk Mesrur   +29 more
core   +1 more source

Drug delivery systems in urology—getting “smarter”

, 2016
Urology holds the most enviable position in the medical firmament. Unique among specialties in bringing the surgeon in contact with humans throughout the spectrum of human life—from newborn to geriatric patients—urologists need to be adept at both ...
Farokhzad, Omid, Dimitrakov, Jordan D., Karp, Jeffrey, Freeman, Michael R., Langer, Robert, Khademhosseini, Ali   +5 more
core   +1 more source

Engineering Human Donor Derived Germinal Center‐Like Organoids (GCLOs) for Studying Immune Response to Vaccination

Advanced Science, EarlyView.
We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar, Carlos Gomez, Giancarlo Asencio, Suresh Pallikkuth, Ashutosh Agarwal   +4 more
wiley   +1 more source

Elevated Visceral Adiposity Index is Associated with Reproductive Endocrine Characteristics, and Adverse Pregnancy Outcomes in Chinese Women with Polycystic Ovary Syndrome

International Journal of Women's Health
Baichao Shi,1 Jiaxing Feng,2 Fengjuan Lu,1 Muxin Guan,1 Jiannan Yu,1 Zhuwei Gao,1 Yu Wang,2 Jing Cong,2 Hongli Ma,2 Conghui Han,3 Wen Yang,4 Xiaoke Wu,2,5 Jingshu Gao5 1Graduate School, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang ...
Shi B, Feng J, Lu F, Guan M, Yu J, Gao Z, Wang Y, Cong J, Ma H, Han C, Yang W, Wu X, Gao J   +12 more
doaj  

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Multi‐Stimuli Responsive Magneto‐Coacervate Droplets for Selective Molecular Enrichment and Programmable Manipulation

Advanced Science, EarlyView.
ABSTRACT Coacervate droplets formed via liquid–liquid phase separation offer unique opportunities as microreactors and delivery vehicles due to their ability to selectively concentrate biomolecules and support biochemical reactions. However, their passive nature severely restricts precise spatial and temporal control, posing barriers to practical ...
Kailang Liu, Haocheng Ran, Haohui Ou, Peiying Chen, Cheng Qi, Tiantian Kong, Zhou Liu   +6 more
wiley   +1 more source

RNA Binding Motif Protein 15 (RBM15): Structure, Function and Its Research Progress in Tumors

International Journal of General Medicine
Xiangyu Long,* Bintao Hu,* Shiqing Zhu, Yue Wu, Tao Wang Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China*These authors ...
Long X, Hu B, Zhu S, Wu Y, Wang T
doaj  

Training potential in minimally invasive surgery in a tertiary care, paediatric urology centre

, 2015
Background Minimally invasive surgery (MIS) is being utilized more frequently as a surgical technique in general surgery and in paediatric urology. It is associated with a steep learning curve.
Klijn, A. J., Kuijper, C. F., Schroeder, R. P. J., Dik, P., Chrzan, R. J., de Jong, T. P. V. M.   +5 more
core   +1 more source