Results 81 to 90 of about 382,165 (310)

Online Interest in Urology Residency: A Comprehensive Analysis of Current Internet Temporal and Geographic Patterns

International Medical Education
Urology is one of the most competitive specialties in medicine, creating a challenge for prospective students looking to secure a residency position. Our study aims to assess online interest in urology residency by querying online interaction with search
Arthur Drouaud, Ryan Antar, Vincent Xu, Paul Nagao, Sean Tafuri, Michael Whalen   +5 more
doaj   +1 more source

Bitter sweet: Fournier’s Gangrene and SGLT2 inhibitors

University of Ottawa Journal of Medicine, 2019
Diabetes mellitus, especially type 2 is becoming the biggest epidemic of the 21st century affecting more than 415 million adults globally and expected to increase to more than 640 million adults by 2040.
Coralea Kappel
doaj   +1 more source

Knowledge and Attitude of European Urology Residents About Ionizing Radiation

, 2013
OBJECTIVE To evaluate the attitude and knowledge of urology residents concerning ionizing radiation, we undertook a survey of European urology residents.
Silay, Mesrur Selcuk, Soylemez, Haluk, Sancaktutar, Ahmet Ali, Altunoluk, Bulent, Atar, Murat, Penbegül, Necmettin, Bozkurt, Yasar   +6 more
core   +1 more source

Systematic review of perioperative and quality-of-life outcomes following surgical management of localised renal cancer [PDF]

, 2012
UCAN Cancer Charity (www.ucanhelp.org.uk) and MacMillan Cancer Charity (www.macmillan.org.uk) helped design and conduct the study.Peer ...
Hilvano-Cabungcal, Ana M., MacLennan, Steven, Griffiths, T. R. Leyshon, Griffiths, T.R. Leyshon, Lapitan, Marie C, Griffiths, TR Leyshon, UCAN Systematic Review Reference Group, Hilvano-Cabungcal, Ana M, MacLennan, Sara J, McClinton, Sam, MacLennan, Sara J., Lam, Thomas B. L., Ljungberg, Börje, N’Dow, James, Royle, Pamela, MacLennan, Graeme, Stewart, Fiona, Dahm, Philipp, Imamura, Mari, Canfield, Steven E, N'Dow, James, Royle, Pam, Lapitan, Marie C., Omar, Muhammad Imran, Lam, Thomas BL, Canfield, Steven E., Lam, Thomas B.L., Ljungberg, Börje,   +27 more
core   +1 more source

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Enhanced NIR-II Nanoparticle Probe for PSMA-Targeted Molecular Imaging and Prostate Cancer Diagnosis

International Journal of Nanomedicine
Zhongji Jiang,1,2 Jin Zhang,3 Jiali Jin,3 Xun Zhang,4 Gaohaer Kadeerhan,5 Hong Guo,3 Dongwen Wang2,6 1Department of Biology, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, People’s Republic of China ...
Jiang Z, Zhang J, Jin J, Zhang X, Kadeerhan G, Guo H, Wang D   +6 more
doaj  

Research Needs for Effective Transition in Lifelong Care of Congenital Genitourinary Conditions: A Workshop Sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases.

, 2017
Over the last 5 decades, health-care advances have yielded quantum improvements in the life expectancy of individuals with congenital genitourinary conditions (CGCs), leading to a crisis of care.
Scal, Peter, Mattoo, Tej K., Star, Robert A., Dosa, Nienke P, Dicianno, Brad E., Star, Robert A, Gomez-Lobo, Veronica, Hsieh, Michael, Wood, Hadley M, Wood, Hadley M., Wright, James E., Mattoo, Tej K, Wright, James E, Norton, Jenna M, Misseri, Rosalia, Hsieh, Michael H, Dicianno, Brad E, Bavendam, Tamara, Norton, Jenna M., Sawin, Kathleen J, Dosa, Nienke P., Sawin, Kathleen J.   +21 more
core   +1 more source