Results 81 to 90 of about 420,448 (359)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Changes in urologic research from a new perspective: Text mining analysis of publication topics [PDF]

Investigative and Clinical Urology
Purpose: This study aimed to explore the trends in research keywords and topics in the field of urology based on text mining over the recent decades. The investigation looked into changes in frequent subject keywords and the trends in prevailing research
Soohyung Joo, Kun Lu, Jihwan Park, Mi Jung Rho, Yong Hyun Park   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

European Association of Urology Guidelines Office Rapid Reaction Group: An Organisation-wide Collaborative Effort to Adapt the European Association of Urology Guidelines Recommendations to the Coronavirus Disease 2019 Era

European Urology, 2020
The coronavirus disease 2019 (COVID-19) pandemic is unlike anything seen before by modern science-based medicine. Health systems across the world are struggling to manage it.
M. Ribal, P. Cornford, A. Briganti, T. Knoll, S. Gravas, M. Babjuk, C. Harding, A. Breda, A. Bex, J. Rassweiler, A. Gözen, G. Pini, E. Liatsikos, G. Giannarini, A. Mottrie, R. Subramaniam, N. Sofikitis, Bernardo M.C. Rocco, Lijiao Xie, J. Witjes, N. Mottet, B. Ljungberg, M. Rouprêt, M. P. Laguna, A. Salonia, G. Bonkat, B. Blok, C. Türk, C. Radmayr, N. Kitrey, D. Engeler, N. Lumen, Oliver W. Hakenberg, N. Watkin, Rizwan Hamid, J. Olsburgh, J. Darraugh, R. Shepherd, E. Smith, Christopher R. Chapple, A. Stenzl, H. van Poppel, M. Wirth, J. Sønksen, J. N'Dow   +44 more
semanticscholar   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Impact of the COVID-19 pandemic on urology residency training in Italy.

Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 2020
In the global emergency scenario caused by COVID-19 pandemic, the Urology residents' training might be critically affected. To provide insights on this issue, a 25-items online Survey was sent to all Italian residents one month after the first case of ...
D. Amparore, F. Claps, G. Cacciamani, F. Esperto, C. Fiori, G. Liguori, S. Serni, C. Trombetta, M. Carini, F. Porpiglia, E. Checcucci, R. Campi   +11 more
semanticscholar   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Increased burden on metropolitan urological services: The era of the Australian National Emergency Access Targets (NEAT or the “4-h target”)

Urology Annals, 2018
Background: The National Emergency Access Targets (NEAT) was introduced in Australia in 2011 and guides the clearance of presentations within 4-h of initial presentation from the Emergency Department (ED).
Marlon L Perera, Neiraja Gnaneswaran, Matthew J Roberts, Nathan Lawrentschuk, Peter Ritchie, Steven TF Chan   +5 more
doaj   +1 more source

Minimal invasive surgery in paediatric urology

, 2015
Minimal invasive surgery (MIS) has developed tremendously during the last 20 years. Nowadays, a wide spectrum of ablative and reconstructive procedures in urology can be done in adults as well as in children.
Kuijper, C. F., Klijn, A. J., Dik, P., de Mooij, K. L., de Jong, T. P V M, Chrzan, R., de Jong, T. P. V. M.   +6 more
core   +1 more source

The Revolving Door of Residency: Predictors of Residency Attrition for Urology Matriculants Between 2001 and 2016

, 2023
To add to the literature which has reported higher attrition rates amongst General Surgery residents who identify as female or underrepresented in medicine (URM), we aimed to determine how these factors contribute to attrition within Urology.
Arslan I. Mohamed, Gurayah, Aaron A., Balumuka, Darius, Darius Balumuka, Mohamed, Arslan I., Ezeh, Uche C., Aaron A. Gurayah, Asafu-Adjei, Denise, Brea Camille Willey, Ramasamy, Ranjith, Rahman, Farah, Ari P. Bernstein, Uche C. Ezeh, Amanda Gosman, Bernstein, Ari P., Willey, Brea Camille, Yarholar, Lauren M, Gosman, Amanda, Lauren M. Yarholar, Farah Rahman, Denise Asafu-Adjei, Ranjith Ramasamy   +21 more
core   +1 more source