Results 61 to 70 of about 361,421 (310)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Retrospective outcome analysis of urethroplasties performed for various etiologies in a single South African centre [PDF]

, 2012
This is the author’s version of a work that was accepted for publication of the article: African Journal of Urology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality ...
Naudé, J.H., Lazarus, John, Wiechers, L, Van Den Heever, A P, J. Lazarus, Naudé, JH, van den Heever, AP, Tsheisi, M., Tsheisi, M, Lazarus, J., A.P. van den Heever, Lazarus, J, Wiechers, L., Naude, J H, L. Wiechers, M. Tsheisi, van den Heever, A.P., J.H. Naudé   +17 more
core   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Attitude and perception of urology by medical students at the end of their medical school: An appraisal from Saudi Arabia

Urology Annals, 2015
Objectives: To evaluate the attitude and perception of the graduates of King Saud University (KSU) College of Medicine regarding the quality of their urology rotation, urology exposure during this rotation, confidence about managing common conditions ...
Saleh Binsaleh, Abdulrahman Al-Jasser, Raed Almannie, Khaled Madbouly   +3 more
doaj   +1 more source

Overview of paediatric urology practice in lagos state university teaching hospital, Ikeja, Lagos, Nigeria

Nigerian Postgraduate Medical Journal, 2020
Introduction: Paediatric urology is one of the subspecialities of urology, and in most climes, it is practised by the urologists and paediatric surgeons, and likewise in the Lagos State University Teaching Hospital (LASUTH). The urologists see and manage
Abimbola Ayodeji Abolarinwa, Olufemi O Ojewuyi, Adaobi U Solarin   +2 more
doaj   +1 more source

Achieving sustainability in urology:a consensus study by the European association of urology (EAU) section office [PDF]

PURPOSE: To assess the awareness, attitudes, and practices related to environmental sustainability among urologists and to explore targeted interventions, educational initiatives to enhance sustainability in urological practice while maintaining high ...
Güven, Selçuk, Ralph, David, Akgül, Burak, Finazzi Agro, Enrico, Bettocchi, Carlo, Soytürk, Selim, Sönmez, Mehmet Giray, Sanguedolce, Francesco, Herrmann, Thomas R. W., Roupret, Morgan, Gadzhiev, Nariman, Vasquez, Juan Luis, Mallet, Richard, Aydın, Abdullatif, Rassweiler, Jens, Knoll, Thomas, Keller, Etienne Xavier, Ahmed, Kamran, Tozsin, Atınç, Colecchia, Maurizio, Musquera, Mireia, Omar, Muhammad Imran, Traxer, Olivier, Dasgupta, Prokar, Arslan, Erkan, Pradere, Benjamin, Çakır, Ömer Onur, Tunç, Lütfi, Herrmann, Thomas R W, Sılay, Selçuk Mesrur   +29 more
core   +1 more source

Efficacy of a Urology Nurse-led Clinic in Queen Mary Hospital of Hong Kong [PDF]

, 2012
INTRODUCTION AND OBJECTIVES: Patients with common urological problems need to wait for a long time (>248 weeks) before they have the first consultation in Queen Mary Hospital of Hong Kong.
Ho, KL, Yiu, MK, Ng, SL, Tse, YB
core   +1 more source