The tumor-associated fibroblasts regulate urothelial carcinoma progression. [PDF]
Xiao Y +15 more
europepmc +1 more source
The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi +5 more
wiley +1 more source
Case Report: Whole-genome sequencing of urothelial carcinoma in an adult patient with CLOVES syndrome reveals a lack of <i>PIK3CA</i> mutation and a genomic landscape consistent with urothelial carcinoma. [PDF]
McAuley L +7 more
europepmc +1 more source
Antibody–Drug Conjugates in Oncology: Principles, Clinical Development, and Future Directions
Antibody–drug conjugates integrate antibody targeting with potent cytotoxic payloads to enable precision cancer therapy. Their clinical performance depends on coordinated optimization of engineering design, tumor antigen biology, and treatment strategy. Lessons from uro‐oncological malignancies illustrate how ADCs can be effectively developed, combined,
Bisheng Cheng +6 more
wiley +1 more source
High-Grade Urothelial Carcinoma Arising From a Ureteral Diverticulum: A Rare Case Report. [PDF]
Papadopoulos I +9 more
europepmc +1 more source
This study identifies C1orf35 as a key driver of colorectal cancer progression through a dual mechanism. It promotes tumor‐intrinsic cell proliferation and migration via the c‐Myc/PYCR2 axis, and suppresses anti‐tumor immunity by impairing CD8+ T‐cell immune surveillance, nominating it as a novel therapeutic target in colorectal cancer.
Shaosen Zhang +6 more
wiley +1 more source
Complete Response to Pembrolizumab After Progression on Avelumab Maintenance in Metastatic Urothelial Carcinoma. [PDF]
Ito F +4 more
europepmc +1 more source
ABSTRACT Objective Women diagnosed with ductal carcinoma in situ (DCIS) and clinicians have reported challenges in communication about DCIS, contributing to women's confusion and anxiety. This study explored how to improve communication about DCIS including alternative labels, language and other strategies.
Suzanna Apostolovski +3 more
wiley +1 more source
Early Recognition of Immune-Related Hepatitis During Avelumab Maintenance Therapy for Urothelial Carcinoma. [PDF]
Iwama Y +9 more
europepmc +1 more source

