Results 111 to 120 of about 5,145,076 (274)

Targeting C12ORF49‐Mediated Ferroptosis in Hepatocellular Carcinoma

JGH Open, Volume 10, Issue 2, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC) remains a leading cause of cancer‐related mortality worldwide, underscoring the urgent need for novel therapeutic strategies. Recent studies have highlighted the pivotal role of ferroptosis, an iron‐dependent form of regulated cell death driven by lipid peroxidation, in cancer biology.
Yuexin Liu, Lizhou Jia, Liu Yang, Zhang Ning, Yanmei Li   +4 more
wiley   +1 more source

Inhibitory effects of ursolic acid from Bushen Yijing Formula on TGF-β1-induced human umbilical vein endothelial cell fibrosis via AKT/mTOR signaling and Snail gene

Journal of Pharmacological Sciences, 2019
The present study aimed to investigate the functional components from Bushen Yijing Formula and their inhibition of endothelial–mesenchymal transition (EndMT) and fibrosis in human umbilical vascular endothelial cells (HUVECs). HUVEC fibrosis was induced
Ke Zhu, Cuixiang Cao, Jiaqi Huang, Zixuan Cheng, Donghai Li, Xiuting Liu, Yueping Mao, Qing Qi   +7 more
doaj   +1 more source

Chemical Constituents of Vitex ovata (Verbenaceae) [PDF]

, 1997
Three compounds, luteolin, ursolic acid and meta-hydroxybenzoic acid were isolated from the leaves of Vitex ovata.
Aimi, Norio, Hamzah, Ahmad Sazali, Lajis, Md Nordin, Ramli, Irmawati   +3 more
core  

Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide [PDF]

, 2004
BACKGROUND: For ≈ 24 years the AIDS pandemic has claimed ≈ 30 million lives, causing ≈ 14,000 new HIV-1 infections daily worldwide in 2003. About 80% of infections occur by heterosexual transmission.
A Robert Neurath, A Stone, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, Asim K Debnath, B Conde-Petit, C Berset, C Ma, CD Pilcher, CD Rizzuto, CW Davis, DH Schwartz, DJ Bacon, E Poyrazoglu, EA Merritt, EG Cormier, G Zhang, H Blaak, H Brown, J Moore, JM Johnson, JP Moore, L Hammar, L Wu, M Hsu, M Seguchi, MA Skinner, N DeTommasi, N Mahmood, N Mahmood, Nathan Strick, P Langley, P Suphaphiphat, P Tomasik, P Westervelt, P Westervelt, PD Kwong, PJ Kraulis, Q Hu, Q Zhao, R Pantophlet, R Shattock, R Stute, R Weiss, RJ Shattock, RJ Shattock, RN Fichorova, RN Fichorova, RS Veazey, S Garg, S Gartner, S Laal, S Liu, S-T Hsu, SH Xiang, TC Pierson, UNAIDS, VJ Tomazic-Jezic, WC Greene, WR Yao, Y Van Herrewege, Yun-Yao Li   +66 more
core   +3 more sources

A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Current immunomodulatory therapies for multiple sclerosis (MS) can effectively inhibit autoimmune response, but largely fail to promote myelin repair.
Y. Zhang, Xing Li, B. Ciric, M. Curtis, Wanjun Chen, A. Rostami, Guang-Xian Zhang   +6 more
semanticscholar   +1 more source

Advances in the Development of Lipid Nanoparticles for mRNA Delivery

Small Structures, Volume 7, Issue 2, February 2026.
This review provides an integrated overview of mRNA–lipid nanoparticle (LNP) design, including lipid composition, scalable manufacturing, and structure–activity relationships. We highlight strategies for targeted delivery, physicochemical tuning, and high‐throughput screening such as DNA barcoding.
Xing Wang, Letao Xu, Zhenwei Lan, Yue Hui, Yun Liu, Guangze Yang, Chun‐Xia Zhao   +6 more
wiley   +1 more source

Pharmacological studies on the laxative effects of Fagonia indica on rodents

Bangladesh Journal of Pharmacology, 2019
This study explores the pharmacological basis for the folk use of Fagonia indica in constipation using in vivo and in vitro assays. The crude extract of F. indica contained tannins, saponins, anthraquinones, alkaloids, flavonoids, glycosides and phenols.
Muhammad Zeeshan Ali, Malik Hassan Mehmood, Muhammad Saleem, Anwar-ul-Hassan Gilani   +3 more
doaj   +1 more source

In‐vivo pilot study to assess a new plant‐based cosmetic formulation containing Ziziphus joazeiro bark extract and Apium graveolens seed extract for the improvement of dandruff while enhancing scalp microbiome balance and barrier function in subjects with oily to dry sensitive scalps

International Journal of Cosmetic Science, Volume 48, Issue 1, Page 51-69, February 2026.
This study comprising dermatological as well as microbiome analysis indicates that mild‐to‐moderate dandruff symptoms can successfully be reduced with a plant‐based shampoo by restoring the bacterial scalp microbiome balance, suggesting a ‘microbiome‐friendly’ formulation tolerated excellently for oily scalp and sensitive scalp.
Phil Barry, Jun Ning Teo, Jing Jing Guo, Peter Engels, Katharina Droste, Annika Kathrin Michaelis, Werner Voss   +6 more
wiley   +1 more source

Antibacterial and Synergistic Activity of Pentacyclic Triterpenoids Isolated from Alstonia scholaris

Molecules, 2016
(1) Background: Alstonia scholaris (Apocynaceae) is an important medicinal plant that has been historically used in “Dai” ethnopharmacy to treat infectious diseases in China.
Chao-Min Wang, Hsiao-Ting Chen, Zong-Yen Wu, Yun-Lian Jhan, Ching-Lin Shyu, Chang-Hung Chou   +5 more
doaj   +1 more source

Inhibitory activity of Kaki calyx extracts and their triterpene compounds on recombinant hepatitis C virus NS3/4A protease [PDF]

, 2018
柿蔕のヘキサン、メタノール、50 % アセトン抽出物の、組み替えhepatitis C virus (HCV)の NS3/4A 蛋白質分解酵素に対する阻害活性を検討した。50 % アセトン抽出物が最も阻害活性が強く、この抽出物をSephadex LH20カラムで分画を行なった。得た各画分のうち阻害活性の強かった70 %メタノール画分を、さらにシリカゲルカラム／薄層クロマトグラフィーで分画し、トリテルペンのベルリン酸、オレアノール酸、ウルソール酸を分離した。これらのトリテルペンはpolycyclic ...
Isao OHTSUKA, Kazuki TSUCHIYA, Nobuko KAKIUCHI, Tairiku KUROIWA, Toshiyuki ATSUMI, あつみ としゆき, おおつか いさお, かきうち のぶこ, くろいわ たいりく, つちや かずき, 土谷 和紀, 垣内 信子, 大塚 功, 渥美 聡孝, 黒岩 大陸   +14 more
core   +1 more source