Results 211 to 220 of about 5,145,076 (274)

Neuroprotective properties of Betulin, Betulinic acid, and Ursolic acid as triterpenoids derivatives: a comprehensive review of mechanistic studies

Nutritional neuroscience, 2023
Cognitive deficits are the main outcome of neurological disorders whose occurrence has risen over the past three decades. Although there are some pharmacologic approaches approved for managing neurological disorders, it remains largely ineffective. Hence,
Mahan Farzan, Mahour Farzan, M. Shahrani, Seyedeh Parisa Navabi, Hossien Rajabi Vardanjani, Hossein Amini-Khoei, Sahreh Shabani   +6 more
semanticscholar   +1 more source

Therapeutic potential and novel formulations of Ursolic Acid and its Derivatives: An updated review.

The Journal of the Science of Food and Agriculture, 2023
Plants produce biologically active metabolites that have been utilised to cure a variety of severe and persistent illnesses. There is a possibility that understanding how these bioactive molecules work would allow researchers to come up with better ...
Priya Namdeo, B. Gidwani, Sakshi Tiwari, Vishal Jain, V. Joshi, A. Vyas   +5 more
semanticscholar   +1 more source

Ursolic acid: a pentacyclic triterpenoid that exhibits anticancer therapeutic potential by modulating multiple oncogenic targets

Biotechnology & Genetic Engineering Reviews, 2023
The world is currently facing a global challenge against neoplastic diseases. Chemotherapy, hormonal therapy, surgery, and radiation therapy are some approaches used to treat cancer.
S. Sandhu, Sharareh Khorami Rouz, Suneel Kumar, N. Swamy, L. Deshmukh, Arif Hussain, S. Haque, H. Tuli   +7 more
semanticscholar   +1 more source

Ursolic acid nanoparticles for glioblastoma therapy

Nanomedicine: Nanotechnology, Biology and Medicine, 2023
Glioblastoma multiforme (GBM) is the most common and fatal primary tumor in the central nervous system (CNS). The effect of chemotherapy of GBM is limited due to the existence of blood-brain barrier (BBB). The aim of this study is to develop self-assembled nanoparticles (NPs) of ursolic acid (UA) for GBM treatment.UA NPs were synthesized by solvent ...
Yong, Li, Linyao, Zhao, Qingyu, Zhao, Youdong, Zhou, Long, Zhou, Ping, Song, Baohui, Liu, Qianxue, Chen, Gang, Deng   +8 more
openaire   +2 more sources

Oleanolic acid and ursolic acid: therapeutic potential in neurodegenerative diseases, neuropsychiatric diseases and other brain disorders

Nutritional neuroscience, 2022
Brain disorders such as neurodegenerative diseases and neuropsychiatric diseases have become serious threatens to human health and quality of life. Oleanolic acid (OA) and ursolic acid (UA) are pentacyclic triterpenoid isomers widely distributed in ...
Chen Chen, Qidi Ai, A‐xi Shi, Nan Wang, Lina Wang, Yu-hui Wei   +5 more
semanticscholar   +1 more source

Chemical Studies on Ursolic Acid*

Journal of the American Pharmaceutical Association (Scientific ed.), 1953
From ursolic acid, C29H46C29H46{−OH(C−2)−COOH(C−28), there was prepared acetyl ursolyl amide and acetyl ursolyl nitrile, both of which were reduced by lithium aluminum hydride to an ursolyl amine (C–28), C29H46{−OH−CH2NH2. By a similar reduction of ursonic acid oxime there was obtained an isomeric ursolyl amine (C–2), C29H46{−NH2−CH2OH. Methyl ursonate,
B Y, WU, L M, PARKS
openaire   +2 more sources

Advances in Anti-inflammatory Activity, Mechanism and Therapeutic Application of Ursolic Acid.

Mini-Reviews in Medical Chemistry, 2021
In vivo and in vitro studies reveal that ursolic acid (UA) is able to counteract endogenous and exogenous inflammatory stimuli, and has favorable anti-inflammatory effects.
Mingzhu Luan, Huiyun Wang, Jiazhen Wang, Xiaofan Zhang, Fenglan Zhao, Zongliang Liu, Qingguo Meng   +6 more
semanticscholar   +1 more source

Oleanolic acid and ursolic acid stabilize liposomal membranes

Lipids, 1997
AbstractThe effects of oleanolic acid (OA) and ursolic acid (UA) on the fluidity and stability of dipalmitoyl phosphatidylcholine (DPPC) liposomal membrane were monitored by measuring the fluorescence polarization of 1,6‐diphenyl‐1,3,5‐hexatriene labeled in the liposomal membrane and the leakage of calcein from the probe‐encapsulated liposomes.
S K, Han, Y I, Ko, S J, Park, I J, Jin, Y M, Kim   +4 more
openaire   +2 more sources

Ursolic Acid Inhibits Acid Sphingomyelinase in Intestinal Cells

Phytotherapy Research, 2012
Ursolic acid (UA) has antiinflammatory and anticancer effects on mammalian cells. Increase in acid sphingomyelinase (SMase) is associated with several inflammatory diseases including inflammatory bowel diseases. The enzyme has become a target for drug discovery. The present study examined the roles of UA on acid SMase in intestinal cells. We found that
Ping, Zhang, Yajun, Cheng, Rui-Dong, Duan   +2 more
openaire   +2 more sources

Synthesis and Antimicrobial Activity of Ursolic Acid Ester Derivatives

Chemistry and Biodiversity, 2021
Infections caused by microorganisms are a major cause of morbidity and mortality worldwide, and natural products continue to be important sources for the discovery of new antimicrobial agents. Ursolic acid is a triterpene with known antibacterial action,
V. V. Pereira, Nara Rúbia Pereira, R. Pereira, L. Duarte, J. Takahashi, R. Silva   +5 more
semanticscholar   +1 more source