Results 41 to 50 of about 81,528 (247)

Autoimmune Theories of Chronic Spontaneous Urticaria

Frontiers in Immunology, 2019
Urticaria (hives) is a highly prevalent skin disorder that can occur with or without associated angioedema. Chronic spontaneous urticaria (CSU) is a condition which persists for more than 6 weeks in duration and occurs in the absence of an identifiable ...
S. Bracken, S. Abraham, A. MacLeod
semanticscholar   +1 more source

Biomarkers and clinical characteristics of autoimmune chronic spontaneous urticaria: Results of the PURIST Study

Allergy. European Journal of Allergy and Clinical Immunology, 2019
Autoimmune chronic spontaneous urticaria (aiCSU) is an important subtype of chronic spontaneous urticaria (CSU) in which functional IgG autoantibodies to IgE or its high‐affinity receptor (FcεRI) induces mast cell degranulation and subsequent symptom ...
N. Schoepke, R. Asero, A. Ellrich, M. Ferrer, Ana M. Giménez-Arnau, Clive E. H. Grattan, T. Jakob, G. Konstantinou, U. Raap, P. Skov, P. Staubach, A. Kromminga, Ke-jun Zhang, C. Bindslev‐Jensen, A. Daschner, T. Kinaciyan, E. Knol, M. Makris, N. Marrouche, P. Schmid‐Grendelmeier, G. Sussman, E. Toubi, M. Church, M. Maurer   +23 more
semanticscholar   +1 more source

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Prediction of Relapse and Glucocorticoid Dependence in Eosinophilic Granulomatosis With Polyangiitis: Findings From a Large European Cohort

Arthritis &Rheumatology, EarlyView.
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a small vessel vasculitis characterized by eosinophilia, asthma, and ear, nose, and throat (ENT) involvement. Although glucocorticoids (GCs) are effective in controlling symptoms, relapses and GC dependence are common. The aim of this study was to develop predictive models for vasculitis
Matthias Papo, Pauline Martinot, Renato A. Sinico, Vítor Silvestre‐Teixeira, Nils Venhoff, Maria‐Letizia Urban, Michele Iudici, Juliane Mahrhold, Francesco Locatelli, Giulia Cassone, Franco Schiavon, Benjamin Seeliger, Thomas Neumann, Claudia Feder, Matthieu Groh, Chiara Marvisi, Maxime Samson, Thomas Barba, David Jayne, Arianna Troilo, Jens Thiel, Bernhard Hellmich, Sara Monti, Carlomaurizio Montecucco, Carlo Salvarani, Jean‐Emmanuel Kahn, Bernard Bonnotte, Cécile‐Audrey Durel, Xavier Puéchal, Luc Mouthon, Loïc Guillevin, Giacomo Emmi, Augusto Vaglio, Raphaël Porcher, Benjamin Terrier, on behalf of the French Vasculitis Study Group and the Eosinophilic Granulomatosis with Polyangiitis European Study Group   +35 more
wiley   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Ligelizumab for Chronic Spontaneous Urticaria.

New England Journal of Medicine, 2019
BACKGROUND In the majority of patients with chronic spontaneous urticaria, most currently available therapies do not result in complete symptom control. Ligelizumab is a next-generation high-affinity humanized monoclonal anti-IgE antibody.
M. Maurer, A. Giménez-Arnau, G. Sussman, M. Metz, D. Baker, A. Bauer, J. Bernstein, R. Brehler, C. Chu, W. Chung, I. Danilycheva, C. Grattan, J. Hébert, C. Katelaris, M. Makris, R. Meshkova, S. Savic, R. Sinclair, K. Sitz, P. Staubach, B. Wedi, J. Löffler, A. Barve, K. Kobayashi, E. Hua, T. Severin, R. Janocha   +26 more
semanticscholar   +1 more source

Gut Microbiome and Serum Metabolome Analyses Identify Unsaturated Fatty Acids and Butanoate Metabolism Induced by Gut Microbiota in Patients With Chronic Spontaneous Urticaria

Frontiers in Cellular and Infection Microbiology, 2020
Chronic urticaria (CU) is defined as the continuous or intermittent presence of urticaria for a period exceeding 6 weeks and sometimes occurring with angioedema. Between 66 and 93% of patients with CU have chronic spontaneous urticaria (CSU), the precise
Detong Wang, Shuping Guo, Hongxia He, L. Gong, Hongzhou Cui   +4 more
semanticscholar   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Acute and Chronic Urticaria: Prevalence, Etiologies, Diagnosis, and Treatment

Journal of Mazandaran University of Medical Sciences, 2020
Urticaria is a pruritic skin lesion characterized by rapid onset of blanchable central wheals and marginal flare. Urticaria diseases are categorized on the basis of their duration, etiology, and causes.
Javad Ghaffari, Negar Ghaffari
doaj  

Pure Cold-Induced Cholinergic Urticaria in a Pediatric Patient

Case Reports in Immunology, 2016
Cold urticaria and cholinergic urticaria are two distinct entities. The presentation of exclusive cold-induced cholinergic urticaria is very rare. The patient described herein had experienced urticaria in the exclusive setting of exercising in a cold ...
Tina Abraham, David P. McGarry, John Frith, Jason Casselman, Haig Tcheurekdjian, Robert Hostoffer   +5 more
doaj   +1 more source