Results 41 to 50 of about 50,217 (224)

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source

Clinical Longitudinal Evaluation After Regimen Stop (CLEAR) of Dupilumab in Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Long‐term management strategies for severe chronic rhinosinusitis with nasal polyps (CRSwNP) increasingly include biologic therapy targeting Type 2 inflammation. However, data on outcomes after complete discontinuation of dupilumab following sustained disease control are scarce.
Patrick Huber, Manuel Lasch, Veronika Volgger, Clemens Stihl, Philipp Teupe, Fabienne Oettgen, Sophia Gantner, Moritz Gröger   +7 more
wiley   +1 more source

Biologics Adoption in CRSwNP and the Associated Decline in Endoscopic Sinus Surgery: A Longitudinal Claims Database Study

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Biologic treatments were introduced for chronic rhinosinusitis with nasal polyps (CRSwNP) in 2019. Treatment algorithms for medically refractory CRSwNP remain open, with patients choosing among surgery, biologics, or both. Real‐world utilization of surgery and biologics remains incompletely characterized.
Stephanie Shintani Smith, Sam L. Kaefer, Harsh Duvvuru, Robert C. Kern, Brent A. Senior, Vijay R. Ramakrishnan   +5 more
wiley   +1 more source

Urticária em pré-escolar:: relato de caso e uma breve revisão

, 2023
INTRODUÇÃO: A urticária é uma afecção dermatológica comum em consultas médicas caracterizada pelo surgimento de pápulas e/ou  placas  eritematoedematosas fugazes associada a prurido intenso, que persistem por minutos, horas ou até mesmo dias ...
Marim Bortolotti, Júlia, de Brito Oliveira dos Santos, Ellen, de Lima Moura, Mariah, de Souza Leite, Yasmim, de França Ribeira Espíndola, Gabriela, Corrêa Campos Barreto, Juliana   +5 more
core   +1 more source

Acute and Chronic Urticaria: Prevalence, Etiologies, Diagnosis, and Treatment

Journal of Mazandaran University of Medical Sciences, 2020
Urticaria is a pruritic skin lesion characterized by rapid onset of blanchable central wheals and marginal flare. Urticaria diseases are categorized on the basis of their duration, etiology, and causes.
Javad Ghaffari, Negar Ghaffari
doaj  

Pure Cold-Induced Cholinergic Urticaria in a Pediatric Patient

Case Reports in Immunology, 2016
Cold urticaria and cholinergic urticaria are two distinct entities. The presentation of exclusive cold-induced cholinergic urticaria is very rare. The patient described herein had experienced urticaria in the exclusive setting of exercising in a cold ...
Tina Abraham, David P. McGarry, John Frith, Jason Casselman, Haig Tcheurekdjian, Robert Hostoffer   +5 more
doaj   +1 more source

Efficacy and Safety of Nanoencapsulated Sirolimus Plus Pegadricase: Results From the Randomized, Placebo‐Controlled Phase 3 Trials

Arthritis &Rheumatology, EarlyView.
Objective DISSOLVE I and II examined the efficacy and safety of nanoencapsulated sirolimus (NAS) plus pegadricase (NASP) in patients with uncontrolled gout (UG). Methods In these double‐blind, placebo‐controlled Phase 3 trials of NASP, patients were randomized 1:1:1 to infusions of high‐dose (HD) or low‐dose (LD) NAS plus pegadricase (HD NASP, LD NASP,
Herbert S. B. Baraf, Puja P. Khanna, Milan Petronijevic, Mamuka Lortkipanidze, Anand Patel, Kwabena Ayesu, Michael H. Pillinger, Atul Singhal, Joanna Sobierska, Jacquie Christie, Peter Traber, Rehan Azeem, Wesley DeHaan, Hugues Santin‐Janin, Bhavisha Desai, Alan Kivitz   +15 more
wiley   +1 more source

Urticaria. Interdisciplinary diagnostic and therapeutic recommendations of the Polish Dermatological Society and the Polish Society of Allergology

Przegląd Dermatologiczny, 2020
Urticaria has a complex aetiology and pathogenesis, and is characterized by the presence of wheals with accompanying pruritus or skin burning sensation. In 40% of cases, urticaria may be accompanied by angioedema. Depending on the duration, urticaria may
doaj   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Prevalência e fatores associados a enteroparasitoses em pacientes portadores de urticária crônica [PDF]

, 2023
Enteroparasitoses represent an important public health problem, since these diseases occur predominantly in areas where the population's living conditions are precarious, and are considered neglected diseases.
Sá, Náiade Maria Rêgo Silva de
core   +1 more source