Results 101 to 110 of about 3,807,351 (262)
Cancer Science, EarlyView.Chemically modified siR‐PTBP1 disrupts the Warburg effect by reprogramming pyruvate kinase splicing from PKM2 to PKM1. This metabolic shift activates the TCA cycle, increases ATP production, and excessive ROS generation, and ultimately induces apoptotic cell death in colorectal cancer cells.
Keita Matsumoto +19 more
wiley +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley +1 more source
Long‐read sequencing‐based atlas of tissue‐specific expression of DNM1L transcript variants
The FEBS Journal, EarlyView.Targeted long‐read sequencing resolves full‐length DNM1L (Drp1) isoforms and reveals conserved, tissue‐specific expression patterns across human and mouse tissues. Functional assays show that Drp1 isoforms differ in their ability to drive mitochondrial fission, independent of abundance, with specific exons modulating activity.
Feng Yan +19 more
wiley +1 more source
MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions
Immunology, EarlyView.MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula +6 more
wiley +1 more source
A Motor Vehicle Crash as an Early Signal of Alzheimer's Disease and Related Dementias
Journal of the American Geriatrics Society, EarlyView.ABSTRACT Background People with Alzheimer's disease and related dementias (ADRD) are at increased risk of motor vehicle crash (MVC) due to cognitive decline, which often begins years before diagnosis. MVC could serve as an indicator of ADRD‐related cognitive impairment and facilitate earlier diagnosis.
Nina R. Joyce +8 more
wiley +1 more source
Photochemistry and Photobiology, EarlyView.Three methods for substituting on‐site ambient ultraviolet radiation measurements for personal exposure measurements were investigated. Assuming spatial persistency of measurements from high‐grade instruments delivers lowest uncertainties up to distances of 82 km.
F. Lubitz +7 more
wiley +1 more source
Factors influencing the effectiveness of surgical therapy of peri‐implantitis
Periodontology 2000, EarlyView.Abstract Background Surgical therapy is required in the majority of peri‐implantitis cases due to the inconsistent efficacy of non‐surgical approaches. Although surgical treatment generally offers higher predictability, reported success rates vary widely.
Ausra Ramanauskaite +3 more
wiley +1 more source
Integrated AEC Information Services Using Object Methods and a Central Project Model
Computer-Aided Civil and Infrastructure Engineering, 2002 A new paradigm is presented in which design- ers, contractors, and suppliers process project informa- tion, which is stored in a central project model, by using application routines provided on-line as object-oriented methods instead of stand-alone applications.
openaire +1 more source